Cryogen spray cooling for spatially selective photocoagulation: a feasibility study with potential application for treatment of hemangiomas

Bahman Anvari, B. S. Tanenbaum, Thomas E. Milner, Wendy Hoffman, Samireh Said, Cheng Jen Chang, Lih Hueh L. Liaw, Sol Kimel, John S.M.D. Nelson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

The clinical objective in laser treatment of hemangiomas is to photocoagulate the dilated cutaneous blood vessels, while at the same time minimizing nonspecific thermal injury to the overlying epidermis. We present an in-vivo experimental procedure, using a chicken comb animal model, and an infrared feedback system to deliver repetitive cryogen spurts during continuous Nd:YAG laser irradiation. Gross and histologic observations are consistent with calculated thicknesses of protected and damaged tissues, and demonstrate the feasibility of inducing spatially selective photocoagulation when using cryogen spray cooling in conjunction with laser irradiation. Experimental observation of epidermal protection in the chicken comb model suggests selective photocoagulation of subsurface targeted blood vessels for successful treatment of hemangiomas can be achieved by repetitive applications of a cryogen spurt during continuous Nd:YAG laser irradiation.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsFrederic Laffitte, Raimund Hibst, Hans-Dieter Reidenbach, Herbert J. Geschwind, Giulio Maira, et.al.
Pages29-37
Number of pages9
Volume2922
Publication statusPublished - Dec 1 1996
Externally publishedYes
EventLaser Applications in Medicine and Dentistry - Vienna, Austria
Duration: Sep 7 1996Sep 10 1996

Conference

ConferenceLaser Applications in Medicine and Dentistry
CityVienna, Austria
Period9/7/969/10/96

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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