CRP/IL-6/IL-10 Single-Nucleotide Polymorphisms Correlate with the Susceptibility and Severity of Community-Acquired Pneumonia

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Abstract

Objective: To explore the associations of single-nucleotide polymorphisms (SNPs) of the C-reactive protein (CRP), interleukin 6 (IL-6) and IL-10 genes with susceptibility and severity of community-acquired pneumonia (CAP). Materials and Methods: Two hundred seventy-nine CAP patients were selected for the case group and 156 healthy individuals for the control group. Polymerase chain reaction-restriction fragment length polymorphism was performed for genotyping of CRP +1059G/C (rs1800947) and +1846C/T (rs1205), IL-6-597G/A (rs1800797) and-572C/G (rs1800796), and IL-10-592C/A (rs1800872) and-1082G/A (rs1800896). According to CURB-65 score, the patients were assigned into the severe community-acquired pneumonia (SCAP) and non-SCAP groups. Results: The frequencies of the CRP +1846C/T (rs1205) (CT+TT) genotypes and T allele, the IL-6-597G/A (rs1800797) (AA+AG) genotypes and A allele, and the IL-10-592C/A (rs1800872) (CA+AA) genotypes and A allele were higher in the case group than the control group. Furthermore, the frequencies of the CRP +1846C/T (rs1205) (CT+TT) genotypes and T allele, the IL-6-597G/A (rs1800797) A allele, and the IL-10-592C/A (rs1800872) (CA+AA) genotypes and A allele were higher in the SCAP group than in the non-SCAP group. Conclusion: The CRP +1846C/T (rs1205), IL-6-597G/A (rs1800797), and IL-10-592C/A (rs1800872) may be associated with the susceptibility and severity of CAP.

Original languageEnglish
Pages (from-to)732-740
Number of pages9
JournalGenetic Testing and Molecular Biomarkers
Volume20
Issue number12
DOIs
Publication statusPublished - Dec 1 2016

Fingerprint

Interleukin-10
C-Reactive Protein
Single Nucleotide Polymorphism
Interleukin-6
Pneumonia
Alleles
Genotype
Control Groups
Protein C
Restriction Fragment Length Polymorphisms
Polymerase Chain Reaction
Genes

Keywords

  • Community-acquired pneumonia
  • CRP +1059G/C
  • CRP +1846C/T
  • IL-10-1082
  • IL-10-592C/A
  • IL-6-572C/G
  • IL-6-597G/A
  • single-nucleotide polymorphism
  • susceptibility

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

@article{1458504411d54ad79fe470f712fff643,
title = "CRP/IL-6/IL-10 Single-Nucleotide Polymorphisms Correlate with the Susceptibility and Severity of Community-Acquired Pneumonia",
abstract = "Objective: To explore the associations of single-nucleotide polymorphisms (SNPs) of the C-reactive protein (CRP), interleukin 6 (IL-6) and IL-10 genes with susceptibility and severity of community-acquired pneumonia (CAP). Materials and Methods: Two hundred seventy-nine CAP patients were selected for the case group and 156 healthy individuals for the control group. Polymerase chain reaction-restriction fragment length polymorphism was performed for genotyping of CRP +1059G/C (rs1800947) and +1846C/T (rs1205), IL-6-597G/A (rs1800797) and-572C/G (rs1800796), and IL-10-592C/A (rs1800872) and-1082G/A (rs1800896). According to CURB-65 score, the patients were assigned into the severe community-acquired pneumonia (SCAP) and non-SCAP groups. Results: The frequencies of the CRP +1846C/T (rs1205) (CT+TT) genotypes and T allele, the IL-6-597G/A (rs1800797) (AA+AG) genotypes and A allele, and the IL-10-592C/A (rs1800872) (CA+AA) genotypes and A allele were higher in the case group than the control group. Furthermore, the frequencies of the CRP +1846C/T (rs1205) (CT+TT) genotypes and T allele, the IL-6-597G/A (rs1800797) A allele, and the IL-10-592C/A (rs1800872) (CA+AA) genotypes and A allele were higher in the SCAP group than in the non-SCAP group. Conclusion: The CRP +1846C/T (rs1205), IL-6-597G/A (rs1800797), and IL-10-592C/A (rs1800872) may be associated with the susceptibility and severity of CAP.",
keywords = "Community-acquired pneumonia, CRP +1059G/C, CRP +1846C/T, IL-10-1082, IL-10-592C/A, IL-6-572C/G, IL-6-597G/A, single-nucleotide polymorphism, susceptibility",
author = "Chou, {Shou Chu} and Ko, {How Wen} and Ying-Chin Lin",
year = "2016",
month = "12",
day = "1",
doi = "10.1089/gtmb.2016.0156",
language = "English",
volume = "20",
pages = "732--740",
journal = "Genetic Testing and Molecular Biomarkers",
issn = "1945-0265",
publisher = "Mary Ann Liebert Inc.",
number = "12",

}

TY - JOUR

T1 - CRP/IL-6/IL-10 Single-Nucleotide Polymorphisms Correlate with the Susceptibility and Severity of Community-Acquired Pneumonia

AU - Chou, Shou Chu

AU - Ko, How Wen

AU - Lin, Ying-Chin

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Objective: To explore the associations of single-nucleotide polymorphisms (SNPs) of the C-reactive protein (CRP), interleukin 6 (IL-6) and IL-10 genes with susceptibility and severity of community-acquired pneumonia (CAP). Materials and Methods: Two hundred seventy-nine CAP patients were selected for the case group and 156 healthy individuals for the control group. Polymerase chain reaction-restriction fragment length polymorphism was performed for genotyping of CRP +1059G/C (rs1800947) and +1846C/T (rs1205), IL-6-597G/A (rs1800797) and-572C/G (rs1800796), and IL-10-592C/A (rs1800872) and-1082G/A (rs1800896). According to CURB-65 score, the patients were assigned into the severe community-acquired pneumonia (SCAP) and non-SCAP groups. Results: The frequencies of the CRP +1846C/T (rs1205) (CT+TT) genotypes and T allele, the IL-6-597G/A (rs1800797) (AA+AG) genotypes and A allele, and the IL-10-592C/A (rs1800872) (CA+AA) genotypes and A allele were higher in the case group than the control group. Furthermore, the frequencies of the CRP +1846C/T (rs1205) (CT+TT) genotypes and T allele, the IL-6-597G/A (rs1800797) A allele, and the IL-10-592C/A (rs1800872) (CA+AA) genotypes and A allele were higher in the SCAP group than in the non-SCAP group. Conclusion: The CRP +1846C/T (rs1205), IL-6-597G/A (rs1800797), and IL-10-592C/A (rs1800872) may be associated with the susceptibility and severity of CAP.

AB - Objective: To explore the associations of single-nucleotide polymorphisms (SNPs) of the C-reactive protein (CRP), interleukin 6 (IL-6) and IL-10 genes with susceptibility and severity of community-acquired pneumonia (CAP). Materials and Methods: Two hundred seventy-nine CAP patients were selected for the case group and 156 healthy individuals for the control group. Polymerase chain reaction-restriction fragment length polymorphism was performed for genotyping of CRP +1059G/C (rs1800947) and +1846C/T (rs1205), IL-6-597G/A (rs1800797) and-572C/G (rs1800796), and IL-10-592C/A (rs1800872) and-1082G/A (rs1800896). According to CURB-65 score, the patients were assigned into the severe community-acquired pneumonia (SCAP) and non-SCAP groups. Results: The frequencies of the CRP +1846C/T (rs1205) (CT+TT) genotypes and T allele, the IL-6-597G/A (rs1800797) (AA+AG) genotypes and A allele, and the IL-10-592C/A (rs1800872) (CA+AA) genotypes and A allele were higher in the case group than the control group. Furthermore, the frequencies of the CRP +1846C/T (rs1205) (CT+TT) genotypes and T allele, the IL-6-597G/A (rs1800797) A allele, and the IL-10-592C/A (rs1800872) (CA+AA) genotypes and A allele were higher in the SCAP group than in the non-SCAP group. Conclusion: The CRP +1846C/T (rs1205), IL-6-597G/A (rs1800797), and IL-10-592C/A (rs1800872) may be associated with the susceptibility and severity of CAP.

KW - Community-acquired pneumonia

KW - CRP +1059G/C

KW - CRP +1846C/T

KW - IL-10-1082

KW - IL-10-592C/A

KW - IL-6-572C/G

KW - IL-6-597G/A

KW - single-nucleotide polymorphism

KW - susceptibility

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U2 - 10.1089/gtmb.2016.0156

DO - 10.1089/gtmb.2016.0156

M3 - Article

AN - SCOPUS:85006991618

VL - 20

SP - 732

EP - 740

JO - Genetic Testing and Molecular Biomarkers

JF - Genetic Testing and Molecular Biomarkers

SN - 1945-0265

IS - 12

ER -