Abstract
Objective: To explore the associations of single-nucleotide polymorphisms (SNPs) of the C-reactive protein (CRP), interleukin 6 (IL-6) and IL-10 genes with susceptibility and severity of community-acquired pneumonia (CAP). Materials and Methods: Two hundred seventy-nine CAP patients were selected for the case group and 156 healthy individuals for the control group. Polymerase chain reaction-restriction fragment length polymorphism was performed for genotyping of CRP +1059G/C (rs1800947) and +1846C/T (rs1205), IL-6-597G/A (rs1800797) and-572C/G (rs1800796), and IL-10-592C/A (rs1800872) and-1082G/A (rs1800896). According to CURB-65 score, the patients were assigned into the severe community-acquired pneumonia (SCAP) and non-SCAP groups. Results: The frequencies of the CRP +1846C/T (rs1205) (CT+TT) genotypes and T allele, the IL-6-597G/A (rs1800797) (AA+AG) genotypes and A allele, and the IL-10-592C/A (rs1800872) (CA+AA) genotypes and A allele were higher in the case group than the control group. Furthermore, the frequencies of the CRP +1846C/T (rs1205) (CT+TT) genotypes and T allele, the IL-6-597G/A (rs1800797) A allele, and the IL-10-592C/A (rs1800872) (CA+AA) genotypes and A allele were higher in the SCAP group than in the non-SCAP group. Conclusion: The CRP +1846C/T (rs1205), IL-6-597G/A (rs1800797), and IL-10-592C/A (rs1800872) may be associated with the susceptibility and severity of CAP.
| Original language | English |
|---|---|
| Pages (from-to) | 732-740 |
| Number of pages | 9 |
| Journal | Genetic Testing and Molecular Biomarkers |
| Volume | 20 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 1 2016 |
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Keywords
- Community-acquired pneumonia
- CRP +1059G/C
- CRP +1846C/T
- IL-10-1082
- IL-10-592C/A
- IL-6-572C/G
- IL-6-597G/A
- single-nucleotide polymorphism
- susceptibility
ASJC Scopus subject areas
- Genetics(clinical)
Cite this
CRP/IL-6/IL-10 Single-Nucleotide Polymorphisms Correlate with the Susceptibility and Severity of Community-Acquired Pneumonia. / Chou, Shou Chu; Ko, How Wen; Lin, Ying-Chin.
In: Genetic Testing and Molecular Biomarkers, Vol. 20, No. 12, 01.12.2016, p. 732-740.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CRP/IL-6/IL-10 Single-Nucleotide Polymorphisms Correlate with the Susceptibility and Severity of Community-Acquired Pneumonia
AU - Chou, Shou Chu
AU - Ko, How Wen
AU - Lin, Ying-Chin
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Objective: To explore the associations of single-nucleotide polymorphisms (SNPs) of the C-reactive protein (CRP), interleukin 6 (IL-6) and IL-10 genes with susceptibility and severity of community-acquired pneumonia (CAP). Materials and Methods: Two hundred seventy-nine CAP patients were selected for the case group and 156 healthy individuals for the control group. Polymerase chain reaction-restriction fragment length polymorphism was performed for genotyping of CRP +1059G/C (rs1800947) and +1846C/T (rs1205), IL-6-597G/A (rs1800797) and-572C/G (rs1800796), and IL-10-592C/A (rs1800872) and-1082G/A (rs1800896). According to CURB-65 score, the patients were assigned into the severe community-acquired pneumonia (SCAP) and non-SCAP groups. Results: The frequencies of the CRP +1846C/T (rs1205) (CT+TT) genotypes and T allele, the IL-6-597G/A (rs1800797) (AA+AG) genotypes and A allele, and the IL-10-592C/A (rs1800872) (CA+AA) genotypes and A allele were higher in the case group than the control group. Furthermore, the frequencies of the CRP +1846C/T (rs1205) (CT+TT) genotypes and T allele, the IL-6-597G/A (rs1800797) A allele, and the IL-10-592C/A (rs1800872) (CA+AA) genotypes and A allele were higher in the SCAP group than in the non-SCAP group. Conclusion: The CRP +1846C/T (rs1205), IL-6-597G/A (rs1800797), and IL-10-592C/A (rs1800872) may be associated with the susceptibility and severity of CAP.
AB - Objective: To explore the associations of single-nucleotide polymorphisms (SNPs) of the C-reactive protein (CRP), interleukin 6 (IL-6) and IL-10 genes with susceptibility and severity of community-acquired pneumonia (CAP). Materials and Methods: Two hundred seventy-nine CAP patients were selected for the case group and 156 healthy individuals for the control group. Polymerase chain reaction-restriction fragment length polymorphism was performed for genotyping of CRP +1059G/C (rs1800947) and +1846C/T (rs1205), IL-6-597G/A (rs1800797) and-572C/G (rs1800796), and IL-10-592C/A (rs1800872) and-1082G/A (rs1800896). According to CURB-65 score, the patients were assigned into the severe community-acquired pneumonia (SCAP) and non-SCAP groups. Results: The frequencies of the CRP +1846C/T (rs1205) (CT+TT) genotypes and T allele, the IL-6-597G/A (rs1800797) (AA+AG) genotypes and A allele, and the IL-10-592C/A (rs1800872) (CA+AA) genotypes and A allele were higher in the case group than the control group. Furthermore, the frequencies of the CRP +1846C/T (rs1205) (CT+TT) genotypes and T allele, the IL-6-597G/A (rs1800797) A allele, and the IL-10-592C/A (rs1800872) (CA+AA) genotypes and A allele were higher in the SCAP group than in the non-SCAP group. Conclusion: The CRP +1846C/T (rs1205), IL-6-597G/A (rs1800797), and IL-10-592C/A (rs1800872) may be associated with the susceptibility and severity of CAP.
KW - Community-acquired pneumonia
KW - CRP +1059G/C
KW - CRP +1846C/T
KW - IL-10-1082
KW - IL-10-592C/A
KW - IL-6-572C/G
KW - IL-6-597G/A
KW - single-nucleotide polymorphism
KW - susceptibility
UR - http://www.scopus.com/inward/record.url?scp=85006991618&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85006991618&partnerID=8YFLogxK
U2 - 10.1089/gtmb.2016.0156
DO - 10.1089/gtmb.2016.0156
M3 - Article
AN - SCOPUS:85006991618
VL - 20
SP - 732
EP - 740
JO - Genetic Testing and Molecular Biomarkers
JF - Genetic Testing and Molecular Biomarkers
SN - 1945-0265
IS - 12
ER -