CREB and leukemogenesis

Er Chieh Cho, Bryan Mitton, Kathleen M. Sakamoto

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Acute myeloid leukemia (AML) is one of the most common leukemias with a 20% 5-year event-free survival in adults and 50% overall survival in children, despite aggressive chemotherapy treatment and bone marrow transplantation. The incidence and mortality rates for acute leukemia have only slightly decreased over the last 20 years, and therefore greater understanding of the molecular mechanisms associated with leukemic progression is needed. To this end, a number of transcription factors that appear to play a central role in leukemogenesis are being investigated; among them is the cAMP response element binding protein (CREB). CREB is a transcription factor that can regulate downstream targets involving in various cellular functions including cell proliferation, survival, and differentiation. In several studies, the majority of bone marrow samples from patients with acute lymphoid and myeloid leukemia demonstrate CREB overexpression. Moreover, CREB overexpression is associated with a poor outcome in AML patients. This review summarizes the role of CREB in leukemogenesis.

Original languageEnglish
Pages (from-to)37-46
Number of pages10
JournalCritical Reviews in Oncogenesis
Volume16
Issue number1-2
Publication statusPublished - 2011
Externally publishedYes

Fingerprint

Cyclic AMP Response Element-Binding Protein
Acute Myeloid Leukemia
Leukemia
Transcription Factors
Bone Marrow Transplantation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Disease-Free Survival
Cell Differentiation
Cell Survival
Bone Marrow
Cell Proliferation
Drug Therapy
Survival
Mortality
Incidence

Keywords

  • CREB
  • Leukemia
  • Oncogenesis
  • Transcription factors

ASJC Scopus subject areas

  • Cancer Research

Cite this

Cho, E. C., Mitton, B., & Sakamoto, K. M. (2011). CREB and leukemogenesis. Critical Reviews in Oncogenesis, 16(1-2), 37-46.

CREB and leukemogenesis. / Cho, Er Chieh; Mitton, Bryan; Sakamoto, Kathleen M.

In: Critical Reviews in Oncogenesis, Vol. 16, No. 1-2, 2011, p. 37-46.

Research output: Contribution to journalArticle

Cho, EC, Mitton, B & Sakamoto, KM 2011, 'CREB and leukemogenesis', Critical Reviews in Oncogenesis, vol. 16, no. 1-2, pp. 37-46.
Cho EC, Mitton B, Sakamoto KM. CREB and leukemogenesis. Critical Reviews in Oncogenesis. 2011;16(1-2):37-46.
Cho, Er Chieh ; Mitton, Bryan ; Sakamoto, Kathleen M. / CREB and leukemogenesis. In: Critical Reviews in Oncogenesis. 2011 ; Vol. 16, No. 1-2. pp. 37-46.
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