Cortisol awakening response in patients with bipolar disorder during acute episodes and partial remission: A pilot study

Ming Chyi Huang, Shan Chi Chuang, Mei Chih Meg Tseng, Yi Ling Chien, Shih Cheng Liao, Hsi Chung Chen, Po Hsiu Kuo

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

This exploratory study examined the cortisol awakening response (CAR) in patients with bipolar disorder (BPD) at acute phases and partial remission of manic or depressive episodes. Saliva samples of twenty-seven BPD inpatients and 25 healthy controls were collected to determine the CAR patterns, and 12 patients were sampled again at partial remission. BPD patients exhibited a non-enhanced CAR pattern. Lower cortisol expression and a blunted CAR distinguished bipolar-depressive patients from the controls. The intra-individual follow-up for both patient groups revealed a non-significant improvement in CAR patterns, indicating a trend of a normalized CAR after partial remission for BPD patients.

Original languageEnglish
Pages (from-to)594-597
Number of pages4
JournalPsychiatry Research
Volume258
DOIs
Publication statusPublished - Dec 2017

Keywords

  • Bipolar disorder
  • Cortisol awakening response
  • Hypothalamic–pituitary–adrenal axis

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Cortisol awakening response in patients with bipolar disorder during acute episodes and partial remission: A pilot study'. Together they form a unique fingerprint.

Cite this