Cortical sulcal enlargement in catatonic schizophrenia: A planimetric CT study

Georg Northoff, Hagen Waters, Ingeborg Mooren, Uwe Schlüter, Silvia Diekmann, Peter Falkai, Bernhard Bogerts

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

To determine whether patients with catatonic schizophrenia have specific alterations in brain morphology, internal (ventricles) and external (frontal, temporal, parieto-occipital) components of the cerebrospinal fluid (CSF) spaces were examined morphometrically. Planimetric measurements of computed tomographic (CT) scans from 37 patients with catatonic schizophrenia, 28 patients with hebephrenic schizophrenia, and 39 patients with paranoid schizophrenia, all diagnosed according to DSM-III-R criteria, were compared with separate age- and sex-matched non-psychiatric control groups, respectively. The areas of the frontal sulci, the parieto-occipital sulci, the inter-hemispheric fissure, and the lateral and third ventricles were measured separately for the right and left hemispheres. Catatonic patients showed significant enlargements in almost all CSF spaces, especially in the left fronto-temporal area which, in addition, correlated significantly with illness duraton. Hebephrenic patients showed selective enlargements in left temporal and left/right lower frontal cortical sulci, whereas paranoid schizophrenic patients showed no enlargements but significant correlations between left temporal cortical sulcal volume and illness duration. Alterations in temporal cortical areas were present in all three sub-types of schizophrenia. In addition to temporal alterations, hebephrenic schizophrenia was characterised by lower frontal (i.e. orbitofrontal) enlargement. Catatonic schizophrenia, the most severe sub-type with regard to clinical symptomatology and brain pathology, showed fronto-parietal cortical alterations. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)45-54
Number of pages10
JournalPsychiatry Research - Neuroimaging
Volume91
Issue number1
DOIs
Publication statusPublished - 1999

Fingerprint

Catatonic Schizophrenia
Disorganized Schizophrenia
Prefrontal Cortex
Cerebrospinal Fluid
Paranoid Schizophrenia
Occipital Lobe
Third Ventricle
Lateral Ventricles
Brain
Diagnostic and Statistical Manual of Mental Disorders
Schizophrenia
Pathology
Control Groups

Keywords

  • Brain atrophy
  • Catatonia
  • Computed tomography
  • Fronto-temporal connectivity
  • Hebephrenia
  • Paranoid schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Biological Psychiatry
  • Psychology(all)

Cite this

Cortical sulcal enlargement in catatonic schizophrenia : A planimetric CT study. / Northoff, Georg; Waters, Hagen; Mooren, Ingeborg; Schlüter, Uwe; Diekmann, Silvia; Falkai, Peter; Bogerts, Bernhard.

In: Psychiatry Research - Neuroimaging, Vol. 91, No. 1, 1999, p. 45-54.

Research output: Contribution to journalArticle

Northoff, G, Waters, H, Mooren, I, Schlüter, U, Diekmann, S, Falkai, P & Bogerts, B 1999, 'Cortical sulcal enlargement in catatonic schizophrenia: A planimetric CT study', Psychiatry Research - Neuroimaging, vol. 91, no. 1, pp. 45-54. https://doi.org/10.1016/S0925-4927(99)00024-4
Northoff, Georg ; Waters, Hagen ; Mooren, Ingeborg ; Schlüter, Uwe ; Diekmann, Silvia ; Falkai, Peter ; Bogerts, Bernhard. / Cortical sulcal enlargement in catatonic schizophrenia : A planimetric CT study. In: Psychiatry Research - Neuroimaging. 1999 ; Vol. 91, No. 1. pp. 45-54.
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