Cortactin in breast cancer: Analysis with tissue microarray

Shyr Ming Sheen-Chen, Chun Ying Huang, Yu Yin Liu, Chao Cheng Huang, Rei Ping Tang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Tissue microarray (TMA) allows the rapid immunohistochemical analysis of thousands of tissue samples in a parallel fashion. This study was designed to analyze the cortactin status in breast cancer using TMA and to investigate the relationship of cortactin status to breast cancer biology. Patients and Methods: Archival tissue specimens from 99 patients with primary invasive breast cancer were selected. The cortactin expression was analyzed by TMA. Age, estrogen receptor status, histological grading and TNM staging data were also collected. Results: There were 23 patients (23.2%) with low (+) expression of cortactin, 60 patients (60.6%) with intermediate (++) expression and 16(16.2%) with strong (+++) expression. There was no significant relationship between cortactin expression and age, histological grading, primary tumor staging, lymph node status, estrogen receptor and TNM stage. By multivariate analysis, estrogen receptor status and TNM staging were found to be significantly related to the overall five-year survival rate. Conclusion: Cortactin expression failed to demonstrate a prognostic value for patients with breast cancer.

Original languageEnglish
Pages (from-to)293-297
Number of pages5
JournalAnticancer Research
Volume31
Issue number1
Publication statusPublished - Jan 1 2011
Externally publishedYes

Keywords

  • Breast cancer
  • Cortactin
  • Tissue microarray

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Sheen-Chen, S. M., Huang, C. Y., Liu, Y. Y., Huang, C. C., & Tang, R. P. (2011). Cortactin in breast cancer: Analysis with tissue microarray. Anticancer Research, 31(1), 293-297.