Cortactin, fascin, and survivin expression associated with clinicopathological parameters in esophageal squamous cell carcinoma

K. F. Hsu, C. K. Lin, C. P. Yu, C. Tzao, S. C. Lee, Y. Y. Lee, W. C. Tsai, J. S. Jin

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Cortactin, fascin, and survivin have been documented in several human cancers and play important roles in tumor progression. We collected 57 surgical specimens, including esophageal squamous cell carcinomas (SqCC; 7 well-differentiated, 15 moderately differentiated, and 24 poorly differentiated), 3 dysplasias, and 8 normal esophageal tissues. Tissue microarrays were constructed and the immunostaining scores for cortactin, fascin, and survivin were assessed. In 46 SqCC specimens, we examined the relationship between the expression of three biomarkers and tumor differentiation or clinical parameters. Higher immunostaining scores for cortactin, fascin, and survivin correlated positively with tumor differentiation of esophageal SqCC. Univariate survival analysis showed significantly worse prognosis in patients with high scores of cortactin (≥290), fascin (≥245), and survivin (score ≥ 175), poor differentiation, T4 stage, positive for lymph node metastasis, and positive for distant metastasis. In multivariate survival analysis, high scores of survivin (≥175) and poor differentiation were independent risk factors for worse prognosis. Our results demonstrated that higher expression of survivin may be related to tumor progression and it is an independent risk factor for poor survival time of esophageal SqCC. Survivin may be a good biomarker to be applied in clinic to predict the prognosis of esophageal SqCC.

Original languageEnglish
Pages (from-to)402-408
Number of pages7
JournalDiseases of the Esophagus
Volume22
Issue number5
DOIs
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

Cortactin
Survival Analysis
Neoplasms
Neoplasm Metastasis
Tumor Biomarkers
Multivariate Analysis
Biomarkers
Lymph Nodes
Survival
Esophageal Squamous Cell Carcinoma
fascin

Keywords

  • Cortactin
  • Esophageal squamous cell carcinoma
  • Fascin
  • Immunostaining scores
  • Survivin

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Cortactin, fascin, and survivin expression associated with clinicopathological parameters in esophageal squamous cell carcinoma. / Hsu, K. F.; Lin, C. K.; Yu, C. P.; Tzao, C.; Lee, S. C.; Lee, Y. Y.; Tsai, W. C.; Jin, J. S.

In: Diseases of the Esophagus, Vol. 22, No. 5, 2009, p. 402-408.

Research output: Contribution to journalArticle

Hsu, K. F. ; Lin, C. K. ; Yu, C. P. ; Tzao, C. ; Lee, S. C. ; Lee, Y. Y. ; Tsai, W. C. ; Jin, J. S. / Cortactin, fascin, and survivin expression associated with clinicopathological parameters in esophageal squamous cell carcinoma. In: Diseases of the Esophagus. 2009 ; Vol. 22, No. 5. pp. 402-408.
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