Correlation of Serum Leptin Concentrations with Body Composition and Gender in Taiwanese Hemodialysis Patients without Diabetes

Jenn Yeu Wang, Kuo Cheng Lu, Yuh Feng Lin, Wei Ming Hu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective. (1) To evaluate the impact of body composition and gender on serum leptin concentration in hemodialysis patients. (2) To study which marker of adiposity is most appropriate in Taiwanese hemodialysis patients without diabetes. (3) To compare the nutrition status between nonlean and lean subjects. Patients and Methods. Serum leptin concentrations were measured by radioimmunoassay collected in 88 hemodialysis patients without diabetes. Bioimpedance analysis was performed to determine percent fat mass (%FM), lean body mass (LM), and total body water (TBW). Body mass index (BMI) was calculated as weight/height2. Albumin and transferrin were measured by standard laboratory methods. Results. Serum leptin levels were more correlated with percent fat mass (r = 0.697; P <0.001) than with body fat mass (r = 0.672; P <0.001) or with BMI (r = 0.594; P <0.001) in the group as a whole and in each subgroup when analyzed separately by gender. The mean (±SD) serum leptin levels were 32.5 ± 34.3 ng mL -1 in women subjects and 13.6 ± 15.5 ng mL-1 in men subjects (P <0.001). Multiple regression analysis in all subjects revealed that serum leptin levels were independently affected by percent fat mass and gender. Adiposity corrected serum leptin, such as leptin/BMI, leptin/percent fat mass, and leptin/body fat mass was significantly different between sexes (P <0.001). The significantly higher serum leptin concentrations in women than in men were observed in obese subjects with BMI >25 kg/m2 (P <0.001) as well as nonobese subjects with BMI 2 (P <0.05). There were no differences in lean mass and albumin between nonlean and lean subjects. Conclusion. Gender and adiposity had impact on serum leptin levels in hemodialysis patients without diabetes. In terms of adiposity, serum leptin levels had stronger correlation with percent fat mass than with body fat mass (FM) or BMI in Taiwanese hemodialysis patients. Steady-state serum leptin levels could serve as valuable clinical markers for the body adiposity in stable hemodialysis patients without diabetes. Protein malnutrition markers and lean mass should be checked in lean subjects for the evaluation of the protein stores of hemodialysis patients.

Original languageEnglish
Pages (from-to)953-966
Number of pages14
JournalRenal Failure
Volume25
Issue number6
DOIs
Publication statusPublished - 2003
Externally publishedYes

Fingerprint

Leptin
Body Composition
Renal Dialysis
Adiposity
Serum
Body Mass Index
Fats
Albumins
Body Water
Transferrin
Nutritional Status
Malnutrition
Radioimmunoassay
Adipose Tissue
Proteins
Biomarkers
Weights and Measures

Keywords

  • Bioelectrical impedance
  • Body composition
  • Gender
  • Hemodialysis
  • Leptin

ASJC Scopus subject areas

  • Nephrology

Cite this

Correlation of Serum Leptin Concentrations with Body Composition and Gender in Taiwanese Hemodialysis Patients without Diabetes. / Wang, Jenn Yeu; Lu, Kuo Cheng; Lin, Yuh Feng; Hu, Wei Ming.

In: Renal Failure, Vol. 25, No. 6, 2003, p. 953-966.

Research output: Contribution to journalArticle

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abstract = "Objective. (1) To evaluate the impact of body composition and gender on serum leptin concentration in hemodialysis patients. (2) To study which marker of adiposity is most appropriate in Taiwanese hemodialysis patients without diabetes. (3) To compare the nutrition status between nonlean and lean subjects. Patients and Methods. Serum leptin concentrations were measured by radioimmunoassay collected in 88 hemodialysis patients without diabetes. Bioimpedance analysis was performed to determine percent fat mass ({\%}FM), lean body mass (LM), and total body water (TBW). Body mass index (BMI) was calculated as weight/height2. Albumin and transferrin were measured by standard laboratory methods. Results. Serum leptin levels were more correlated with percent fat mass (r = 0.697; P <0.001) than with body fat mass (r = 0.672; P <0.001) or with BMI (r = 0.594; P <0.001) in the group as a whole and in each subgroup when analyzed separately by gender. The mean (±SD) serum leptin levels were 32.5 ± 34.3 ng mL -1 in women subjects and 13.6 ± 15.5 ng mL-1 in men subjects (P <0.001). Multiple regression analysis in all subjects revealed that serum leptin levels were independently affected by percent fat mass and gender. Adiposity corrected serum leptin, such as leptin/BMI, leptin/percent fat mass, and leptin/body fat mass was significantly different between sexes (P <0.001). The significantly higher serum leptin concentrations in women than in men were observed in obese subjects with BMI >25 kg/m2 (P <0.001) as well as nonobese subjects with BMI 2 (P <0.05). There were no differences in lean mass and albumin between nonlean and lean subjects. Conclusion. Gender and adiposity had impact on serum leptin levels in hemodialysis patients without diabetes. In terms of adiposity, serum leptin levels had stronger correlation with percent fat mass than with body fat mass (FM) or BMI in Taiwanese hemodialysis patients. Steady-state serum leptin levels could serve as valuable clinical markers for the body adiposity in stable hemodialysis patients without diabetes. Protein malnutrition markers and lean mass should be checked in lean subjects for the evaluation of the protein stores of hemodialysis patients.",
keywords = "Bioelectrical impedance, Body composition, Gender, Hemodialysis, Leptin",
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T1 - Correlation of Serum Leptin Concentrations with Body Composition and Gender in Taiwanese Hemodialysis Patients without Diabetes

AU - Wang, Jenn Yeu

AU - Lu, Kuo Cheng

AU - Lin, Yuh Feng

AU - Hu, Wei Ming

PY - 2003

Y1 - 2003

N2 - Objective. (1) To evaluate the impact of body composition and gender on serum leptin concentration in hemodialysis patients. (2) To study which marker of adiposity is most appropriate in Taiwanese hemodialysis patients without diabetes. (3) To compare the nutrition status between nonlean and lean subjects. Patients and Methods. Serum leptin concentrations were measured by radioimmunoassay collected in 88 hemodialysis patients without diabetes. Bioimpedance analysis was performed to determine percent fat mass (%FM), lean body mass (LM), and total body water (TBW). Body mass index (BMI) was calculated as weight/height2. Albumin and transferrin were measured by standard laboratory methods. Results. Serum leptin levels were more correlated with percent fat mass (r = 0.697; P <0.001) than with body fat mass (r = 0.672; P <0.001) or with BMI (r = 0.594; P <0.001) in the group as a whole and in each subgroup when analyzed separately by gender. The mean (±SD) serum leptin levels were 32.5 ± 34.3 ng mL -1 in women subjects and 13.6 ± 15.5 ng mL-1 in men subjects (P <0.001). Multiple regression analysis in all subjects revealed that serum leptin levels were independently affected by percent fat mass and gender. Adiposity corrected serum leptin, such as leptin/BMI, leptin/percent fat mass, and leptin/body fat mass was significantly different between sexes (P <0.001). The significantly higher serum leptin concentrations in women than in men were observed in obese subjects with BMI >25 kg/m2 (P <0.001) as well as nonobese subjects with BMI 2 (P <0.05). There were no differences in lean mass and albumin between nonlean and lean subjects. Conclusion. Gender and adiposity had impact on serum leptin levels in hemodialysis patients without diabetes. In terms of adiposity, serum leptin levels had stronger correlation with percent fat mass than with body fat mass (FM) or BMI in Taiwanese hemodialysis patients. Steady-state serum leptin levels could serve as valuable clinical markers for the body adiposity in stable hemodialysis patients without diabetes. Protein malnutrition markers and lean mass should be checked in lean subjects for the evaluation of the protein stores of hemodialysis patients.

AB - Objective. (1) To evaluate the impact of body composition and gender on serum leptin concentration in hemodialysis patients. (2) To study which marker of adiposity is most appropriate in Taiwanese hemodialysis patients without diabetes. (3) To compare the nutrition status between nonlean and lean subjects. Patients and Methods. Serum leptin concentrations were measured by radioimmunoassay collected in 88 hemodialysis patients without diabetes. Bioimpedance analysis was performed to determine percent fat mass (%FM), lean body mass (LM), and total body water (TBW). Body mass index (BMI) was calculated as weight/height2. Albumin and transferrin were measured by standard laboratory methods. Results. Serum leptin levels were more correlated with percent fat mass (r = 0.697; P <0.001) than with body fat mass (r = 0.672; P <0.001) or with BMI (r = 0.594; P <0.001) in the group as a whole and in each subgroup when analyzed separately by gender. The mean (±SD) serum leptin levels were 32.5 ± 34.3 ng mL -1 in women subjects and 13.6 ± 15.5 ng mL-1 in men subjects (P <0.001). Multiple regression analysis in all subjects revealed that serum leptin levels were independently affected by percent fat mass and gender. Adiposity corrected serum leptin, such as leptin/BMI, leptin/percent fat mass, and leptin/body fat mass was significantly different between sexes (P <0.001). The significantly higher serum leptin concentrations in women than in men were observed in obese subjects with BMI >25 kg/m2 (P <0.001) as well as nonobese subjects with BMI 2 (P <0.05). There were no differences in lean mass and albumin between nonlean and lean subjects. Conclusion. Gender and adiposity had impact on serum leptin levels in hemodialysis patients without diabetes. In terms of adiposity, serum leptin levels had stronger correlation with percent fat mass than with body fat mass (FM) or BMI in Taiwanese hemodialysis patients. Steady-state serum leptin levels could serve as valuable clinical markers for the body adiposity in stable hemodialysis patients without diabetes. Protein malnutrition markers and lean mass should be checked in lean subjects for the evaluation of the protein stores of hemodialysis patients.

KW - Bioelectrical impedance

KW - Body composition

KW - Gender

KW - Hemodialysis

KW - Leptin

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