Abstract
Objective: To investigate the correlation of two important inflammatory biomarkers, plasma osteopontin and neutrophil gelatinase-associated lipocalin (NGAL), with the severity and outcome of pelvic inflammatory disease (PID). Materials and methods: Sixty-one patients with PID, including 25 patients with tubo-ovarian abscess (TOA), were consecutively recruited. Their blood samples were tested for the concentrations of plasma osteopontin and NGAL using enzyme-linked immunosorbent assay. The associations of these biomarkers with TOA, length of hospitalization, and incidence of surgery were also analyzed. Results: Plasma osteopontin level was significantly increased in PID patients with TOA compared to PID patients without TOA (median 107.77ng/mL vs. 72.39ng/mL, p=0.004). However, there was no significant difference for plasma NGAL. If the cutoff level of plasma osteopontin was set at 81.1ng/mL, there was a 76.0% sensitivity and a 24.0% false negative rate in predicting TOA in PID patients. Plasma osteopontin significantly correlated with length of hospital stay (r=0.467, p
| Original language | English |
|---|---|
| Pages (from-to) | 158-161 |
| Number of pages | 4 |
| Journal | Taiwanese Journal of Obstetrics and Gynecology |
| Volume | 53 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2014 |
| Externally published | Yes |
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Keywords
- Length of hospital stay
- Neutrophil gelatinase-associated lipocalin
- Osteopontin
- Pelvic inflammatory disease
- Tubo-ovarian abscess
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Medicine(all)
Cite this
Correlation of plasma osteopontin and neutrophil gelatinase-associated lipocalin levels with the severity and clinical outcome of pelvic inflammatory disease. / Tee, Yi Torng; Wang, Po Hui; Yang, Shun Fa; Tsai, Hsiu Ting; Lee, Shu Kuei; Ko, Jiunn Liang; Lin, Long Yau; Chen, Shiuan Chih.
In: Taiwanese Journal of Obstetrics and Gynecology, Vol. 53, No. 2, 2014, p. 158-161.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Correlation of plasma osteopontin and neutrophil gelatinase-associated lipocalin levels with the severity and clinical outcome of pelvic inflammatory disease
AU - Tee, Yi Torng
AU - Wang, Po Hui
AU - Yang, Shun Fa
AU - Tsai, Hsiu Ting
AU - Lee, Shu Kuei
AU - Ko, Jiunn Liang
AU - Lin, Long Yau
AU - Chen, Shiuan Chih
PY - 2014
Y1 - 2014
N2 - Objective: To investigate the correlation of two important inflammatory biomarkers, plasma osteopontin and neutrophil gelatinase-associated lipocalin (NGAL), with the severity and outcome of pelvic inflammatory disease (PID). Materials and methods: Sixty-one patients with PID, including 25 patients with tubo-ovarian abscess (TOA), were consecutively recruited. Their blood samples were tested for the concentrations of plasma osteopontin and NGAL using enzyme-linked immunosorbent assay. The associations of these biomarkers with TOA, length of hospitalization, and incidence of surgery were also analyzed. Results: Plasma osteopontin level was significantly increased in PID patients with TOA compared to PID patients without TOA (median 107.77ng/mL vs. 72.39ng/mL, p=0.004). However, there was no significant difference for plasma NGAL. If the cutoff level of plasma osteopontin was set at 81.1ng/mL, there was a 76.0% sensitivity and a 24.0% false negative rate in predicting TOA in PID patients. Plasma osteopontin significantly correlated with length of hospital stay (r=0.467, p
AB - Objective: To investigate the correlation of two important inflammatory biomarkers, plasma osteopontin and neutrophil gelatinase-associated lipocalin (NGAL), with the severity and outcome of pelvic inflammatory disease (PID). Materials and methods: Sixty-one patients with PID, including 25 patients with tubo-ovarian abscess (TOA), were consecutively recruited. Their blood samples were tested for the concentrations of plasma osteopontin and NGAL using enzyme-linked immunosorbent assay. The associations of these biomarkers with TOA, length of hospitalization, and incidence of surgery were also analyzed. Results: Plasma osteopontin level was significantly increased in PID patients with TOA compared to PID patients without TOA (median 107.77ng/mL vs. 72.39ng/mL, p=0.004). However, there was no significant difference for plasma NGAL. If the cutoff level of plasma osteopontin was set at 81.1ng/mL, there was a 76.0% sensitivity and a 24.0% false negative rate in predicting TOA in PID patients. Plasma osteopontin significantly correlated with length of hospital stay (r=0.467, p
KW - Length of hospital stay
KW - Neutrophil gelatinase-associated lipocalin
KW - Osteopontin
KW - Pelvic inflammatory disease
KW - Tubo-ovarian abscess
UR - http://www.scopus.com/inward/record.url?scp=84904004176&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84904004176&partnerID=8YFLogxK
U2 - 10.1016/j.tjog.2014.04.006
DO - 10.1016/j.tjog.2014.04.006
M3 - Article
C2 - 25017259
AN - SCOPUS:84904004176
VL - 53
SP - 158
EP - 161
JO - Taiwanese Journal of Obstetrics and Gynecology
JF - Taiwanese Journal of Obstetrics and Gynecology
SN - 1028-4559
IS - 2
ER -