Correlation of plasma osteopontin and neutrophil gelatinase-associated lipocalin levels with the severity and clinical outcome of pelvic inflammatory disease

Yi Torng Tee, Po Hui Wang, Shun Fa Yang, Hsiu Ting Tsai, Shu Kuei Lee, Jiunn Liang Ko, Long Yau Lin, Shiuan Chih Chen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To investigate the correlation of two important inflammatory biomarkers, plasma osteopontin and neutrophil gelatinase-associated lipocalin (NGAL), with the severity and outcome of pelvic inflammatory disease (PID). Materials and methods: Sixty-one patients with PID, including 25 patients with tubo-ovarian abscess (TOA), were consecutively recruited. Their blood samples were tested for the concentrations of plasma osteopontin and NGAL using enzyme-linked immunosorbent assay. The associations of these biomarkers with TOA, length of hospitalization, and incidence of surgery were also analyzed. Results: Plasma osteopontin level was significantly increased in PID patients with TOA compared to PID patients without TOA (median 107.77ng/mL vs. 72.39ng/mL, p=0.004). However, there was no significant difference for plasma NGAL. If the cutoff level of plasma osteopontin was set at 81.1ng/mL, there was a 76.0% sensitivity and a 24.0% false negative rate in predicting TOA in PID patients. Plasma osteopontin significantly correlated with length of hospital stay (r=0.467, p

Original languageEnglish
Pages (from-to)158-161
Number of pages4
JournalTaiwanese Journal of Obstetrics and Gynecology
Volume53
Issue number2
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Length of hospital stay
  • Neutrophil gelatinase-associated lipocalin
  • Osteopontin
  • Pelvic inflammatory disease
  • Tubo-ovarian abscess

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Medicine(all)

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