Correlation of histologic grade with other clinicopathological parameters, intrinsic subtype, and patients' clinical outcome in Taiwanese women

Shou Tung Chen, Hung Wen Lai, Hsin Shun Tseng, Li Sheng Chen, Shou Jen Kuo, Dar Ren Chen

Research output: Contribution to journalArticle

12 Citations (Scopus)


Objective: This study aimed to reveal the relationships between histologic grade and other clinicopathologic parameters including intrinsic subtype in Taiwanese women with breast cancer. Methods: There were 1302 women diagnosed with breast cancer recruited for this study. Histologic grade was scored according to the Nottingham-modified Bloom-Richardson grading system. Results: Higher tumor grade was associated with larger tumor size (P = 0.021), a larger number of lymph node metastases (P = 0.001), advanced clinical stage (P = 0.010), higher human epithelial growth receptor-2 positivity (P <0.001), negative estrogen receptor and progesterone receptor (P <0.0001) status. Triple negative breast cancer (56.6%) and human epithelial growth receptor-2 (44.3%) subtypes were associated with more Grade III breast cancer in contrast to luminal A (22.3%) and B (29.9%) breast cancer. In multivariate Cox regression analysis for cancer-specific survival, histologic grade (hazard ratio = 1.78) was a significant prognostic factor. Conclusions: This study demonstrated that histologic grade is highly correlated with some valuable biomarkers and confirmed the significance of histologic grade in Taiwanese female breast cancers.

Original languageEnglish
Article numberhyr157
Pages (from-to)1327-1335
Number of pages9
JournalJapanese Journal of Clinical Oncology
Issue number12
Publication statusPublished - Dec 2011



  • Breast cancer
  • Estrogen receptor
  • HER-2
  • Histologic grade
  • Progesterone receptor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Radiology Nuclear Medicine and imaging

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