15 Citations (Scopus)

Abstract

STIM1 overexpression has been observed in a portion of colorectal cancer (CRC) patients and associated with cancer cell invasion and migration. To characterize the distinctive expression profiles associated with stromal interaction molecule 1 (STIM1) overexpression/low-expression between CRC subtypes, and further assess the divergence transcription regulation impact of STIM1 between colon (COADs) and rectum (READs) adenocarcinomas in order to depict the role of SOCE pathway in CRCs, we have conducted a comprehensive phenome-transcriptome-interactome analysis to clarify underlying molecular differences of COADs/READs contributed by STIM1. Results demonstrated that a number of novel STIM1-associated signatures have been identified in COADs but not READs. Specifically, the presence of STIM1 overexpression in COADs, which represented a disturbance of the SOCE pathway, was associated with cell migration and cell motility properties. We identified 11 prognostic mRNA/miRNA predictors associated with the overall survival of COAD patients, suggesting the correlation of STIM1-associated features to clinicopathological outcomes. These findings enhance our understanding on differences between CRC subtypes in panoramic view, and suggested STIM1 as a promising therapeutic biomarker in COADs.

Original languageEnglish
Pages (from-to)42169-42182
Number of pages14
JournalOncotarget
Volume6
Issue number39
DOIs
Publication statusPublished - 2015

Fingerprint

Colorectal Neoplasms
Chronic Obstructive Pulmonary Disease
Cell Movement
Stromal Interaction Molecule 1
Gene Expression Profiling
MicroRNAs
Rectum
Colon
Adenocarcinoma
Biomarkers
Messenger RNA
Survival
Neoplasms

Keywords

  • Bioinformatics
  • Colorectal cancer
  • Data mining
  • Stored-operated calcium entry pathway
  • Stromal interaction molecule 1

ASJC Scopus subject areas

  • Oncology

Cite this

Correlation of clinical features and genetic profiles of stromal interaction molecule 1 (STIM1) in colorectal cancers. / Wong, Henry Sung Ching; Chang, Wei Chiao.

In: Oncotarget, Vol. 6, No. 39, 2015, p. 42169-42182.

Research output: Contribution to journalArticle

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AB - STIM1 overexpression has been observed in a portion of colorectal cancer (CRC) patients and associated with cancer cell invasion and migration. To characterize the distinctive expression profiles associated with stromal interaction molecule 1 (STIM1) overexpression/low-expression between CRC subtypes, and further assess the divergence transcription regulation impact of STIM1 between colon (COADs) and rectum (READs) adenocarcinomas in order to depict the role of SOCE pathway in CRCs, we have conducted a comprehensive phenome-transcriptome-interactome analysis to clarify underlying molecular differences of COADs/READs contributed by STIM1. Results demonstrated that a number of novel STIM1-associated signatures have been identified in COADs but not READs. Specifically, the presence of STIM1 overexpression in COADs, which represented a disturbance of the SOCE pathway, was associated with cell migration and cell motility properties. We identified 11 prognostic mRNA/miRNA predictors associated with the overall survival of COAD patients, suggesting the correlation of STIM1-associated features to clinicopathological outcomes. These findings enhance our understanding on differences between CRC subtypes in panoramic view, and suggested STIM1 as a promising therapeutic biomarker in COADs.

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