Correlation between Pyrazinamide Activity and pncA Mutations in Mycobacterium tuberculosis Isolates in Taiwan

Tsi S. Huang, Susan Shin-Jung Lee, Hui Z. Tu, Wen Kuei Huang, Yao Shen Chen, Chung K. Huang, Shue R. Wann, Hsi Hsun Lin, Yung Ching Liu

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37 Citations (Scopus)

Abstract

A total of 76 clinical Mycobacterium tuberculosis isolates from Taiwan were tested for pyrazinamidase activity, pyrazinamide susceptibility, and pncA mutations. Frequency of resistance to PZA rose with increases in resistance to first-line drugs. Of 17 pyrazinamide-resistant strains, 7 (3 of which had not been previously described) possessed mutations in the pncA gene.

Original languageEnglish
Pages (from-to)3672-3673
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume47
Issue number11
DOIs
Publication statusPublished - Nov 2003
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology (medical)

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  • Cite this

    Huang, T. S., Shin-Jung Lee, S., Tu, H. Z., Huang, W. K., Chen, Y. S., Huang, C. K., Wann, S. R., Lin, H. H., & Liu, Y. C. (2003). Correlation between Pyrazinamide Activity and pncA Mutations in Mycobacterium tuberculosis Isolates in Taiwan. Antimicrobial Agents and Chemotherapy, 47(11), 3672-3673. https://doi.org/10.1128/AAC.47.11.3672-3673.2003