Correlation between Pyrazinamide Activity and pncA Mutations in Mycobacterium tuberculosis Isolates in Taiwan

Tsi S. Huang, Susan Shin-Jung Lee, Hui Z. Tu, Wen Kuei Huang, Yao Shen Chen, Chung K. Huang, Shue R. Wann, Hsi Hsun Lin, Yung Ching Liu

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

A total of 76 clinical Mycobacterium tuberculosis isolates from Taiwan were tested for pyrazinamidase activity, pyrazinamide susceptibility, and pncA mutations. Frequency of resistance to PZA rose with increases in resistance to first-line drugs. Of 17 pyrazinamide-resistant strains, 7 (3 of which had not been previously described) possessed mutations in the pncA gene.

Original languageEnglish
Pages (from-to)3672-3673
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume47
Issue number11
DOIs
Publication statusPublished - Nov 2003
Externally publishedYes

Fingerprint

Pyrazinamide
Taiwan
Mycobacterium tuberculosis
Mutation
Pharmaceutical Preparations
Genes
pyrazinamide deamidase

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Correlation between Pyrazinamide Activity and pncA Mutations in Mycobacterium tuberculosis Isolates in Taiwan. / Huang, Tsi S.; Shin-Jung Lee, Susan; Tu, Hui Z.; Huang, Wen Kuei; Chen, Yao Shen; Huang, Chung K.; Wann, Shue R.; Lin, Hsi Hsun; Liu, Yung Ching.

In: Antimicrobial Agents and Chemotherapy, Vol. 47, No. 11, 11.2003, p. 3672-3673.

Research output: Contribution to journalArticle

Huang, Tsi S. ; Shin-Jung Lee, Susan ; Tu, Hui Z. ; Huang, Wen Kuei ; Chen, Yao Shen ; Huang, Chung K. ; Wann, Shue R. ; Lin, Hsi Hsun ; Liu, Yung Ching. / Correlation between Pyrazinamide Activity and pncA Mutations in Mycobacterium tuberculosis Isolates in Taiwan. In: Antimicrobial Agents and Chemotherapy. 2003 ; Vol. 47, No. 11. pp. 3672-3673.
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