Abstract

The objective of this study was to verify that the [F-18]FDG PET synovial uptake is correlated with the synovial fluid (SF) TNF-α concentration. Two rabbit models of acute inflammatory arthritis induced by human interleukin-8 and lipopolysaccharide were used. Modified standard uptake values (MSUVs) obtained from PET images of the animals were compared with results of SF TNF-α measurements. Statistically significant correlations were found between the MSUVs and the SF TNF-α ratios. An equation to estimate the TNF-α ratio from a MSUV was also derived.

Original languageEnglish
Pages (from-to)1221-1226
Number of pages6
JournalApplied Radiation and Isotopes
Volume65
Issue number11
DOIs
Publication statusPublished - Nov 2007

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arthritis
rabbits
fluids
interleukins
animals
estimates

Keywords

  • [F]-fluoro-2-deoxyglucose
  • Arthritis severity
  • Inflammatory arthritis
  • Positron emission tomography
  • Tumor necrosis factor alpha

ASJC Scopus subject areas

  • Radiation

Cite this

Correlation between joint [F-18] FDG PET uptake and synovial TNF-α concentration : A study with two rabbit models of acute inflammatory arthritis. / Lin, Po Wei; Liu, Ren Shyan; Liou, Tsan Hon; Pan, Li Chern; Chen, Chi-Hsien.

In: Applied Radiation and Isotopes, Vol. 65, No. 11, 11.2007, p. 1221-1226.

Research output: Contribution to journalArticle

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abstract = "The objective of this study was to verify that the [F-18]FDG PET synovial uptake is correlated with the synovial fluid (SF) TNF-α concentration. Two rabbit models of acute inflammatory arthritis induced by human interleukin-8 and lipopolysaccharide were used. Modified standard uptake values (MSUVs) obtained from PET images of the animals were compared with results of SF TNF-α measurements. Statistically significant correlations were found between the MSUVs and the SF TNF-α ratios. An equation to estimate the TNF-α ratio from a MSUV was also derived.",
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