Correlation between carbapenem consumption and resistance to carbapenems among Enterobacteriaceae isolates collected from patients with intra-abdominal infections at five medical centers in Taiwan, 2006-2010

Cheng Mao Ho, Mao Wang Ho, Yung Ching Liu, Han Siong Toh, Yu Lin Lee, Yuag Meng Liu, Chi Chang Huang, Po Liang Lu, Chun Eng Liu, Yen Hsu Chen, Wen Chien Ko, Hung Jen Tang, Kwok Woon Yu, Yao Shen Chen, Yin Ching Chuang, Jen Hsien Wang, Po Ren Hsueh

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We investigated the trend in resistance to carbapenems among isolates of Enterobacteriaceae that had been collected from patients with intra-abdominal infections at five medical centers in Taiwan from 2006 to 2010 and evaluated the correlation between resistance to carbapenems and consumption of said agents as part of the Study for Monitoring Antimicrobial Resistance Trends (SMART). During the study period, the usage of ertapenem and that of total carbapenems (ertapenem, imipenem, and meropenem) increased significantly from 6.13 to 13.38 defined daily doses per 1000 patient-days for ertapenem and from 20.43 to 34.25 defined daily doses per 1000 patient-days for total carbapenems. The most common species were Escherichia coli (n = 1095), Klebsiella spp. (n = 663), and Enterobacter spp. (n = 202). The susceptibility of all isolates to ertapenem and to imipenem varied during the study period. For ertapenem, the rates of nonsusceptibility ranged from 3.5 to 10.3 and those for imipenem ranged from 3.5 to 10.7. Although the use of carbapenems increased during the study period, there was no marked increase in resistance to carbapenems. Continuous monitoring of resistance trends is necessary so that antimicrobial prescription policies can be adjusted and infection control intervention programs can be implemented.

Original languageEnglish
JournalInternational Journal of Antimicrobial Agents
Volume40
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Jun 2012

Fingerprint

Intraabdominal Infections
Carbapenems
Enterobacteriaceae
Taiwan
Imipenem
meropenem
Enterobacter
Klebsiella
Infection Control
Prescriptions
ertapenem
Escherichia coli

Keywords

  • Carbapenem consumption
  • Carbapenem resistance
  • Enterobacteriaceae
  • Intra-abdominal infections
  • SMART

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Correlation between carbapenem consumption and resistance to carbapenems among Enterobacteriaceae isolates collected from patients with intra-abdominal infections at five medical centers in Taiwan, 2006-2010. / Ho, Cheng Mao; Ho, Mao Wang; Liu, Yung Ching; Toh, Han Siong; Lee, Yu Lin; Liu, Yuag Meng; Huang, Chi Chang; Lu, Po Liang; Liu, Chun Eng; Chen, Yen Hsu; Ko, Wen Chien; Tang, Hung Jen; Yu, Kwok Woon; Chen, Yao Shen; Chuang, Yin Ching; Wang, Jen Hsien; Hsueh, Po Ren.

In: International Journal of Antimicrobial Agents, Vol. 40, No. SUPPL. 1, 06.2012.

Research output: Contribution to journalArticle

Ho, Cheng Mao ; Ho, Mao Wang ; Liu, Yung Ching ; Toh, Han Siong ; Lee, Yu Lin ; Liu, Yuag Meng ; Huang, Chi Chang ; Lu, Po Liang ; Liu, Chun Eng ; Chen, Yen Hsu ; Ko, Wen Chien ; Tang, Hung Jen ; Yu, Kwok Woon ; Chen, Yao Shen ; Chuang, Yin Ching ; Wang, Jen Hsien ; Hsueh, Po Ren. / Correlation between carbapenem consumption and resistance to carbapenems among Enterobacteriaceae isolates collected from patients with intra-abdominal infections at five medical centers in Taiwan, 2006-2010. In: International Journal of Antimicrobial Agents. 2012 ; Vol. 40, No. SUPPL. 1.
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abstract = "We investigated the trend in resistance to carbapenems among isolates of Enterobacteriaceae that had been collected from patients with intra-abdominal infections at five medical centers in Taiwan from 2006 to 2010 and evaluated the correlation between resistance to carbapenems and consumption of said agents as part of the Study for Monitoring Antimicrobial Resistance Trends (SMART). During the study period, the usage of ertapenem and that of total carbapenems (ertapenem, imipenem, and meropenem) increased significantly from 6.13 to 13.38 defined daily doses per 1000 patient-days for ertapenem and from 20.43 to 34.25 defined daily doses per 1000 patient-days for total carbapenems. The most common species were Escherichia coli (n = 1095), Klebsiella spp. (n = 663), and Enterobacter spp. (n = 202). The susceptibility of all isolates to ertapenem and to imipenem varied during the study period. For ertapenem, the rates of nonsusceptibility ranged from 3.5 to 10.3 and those for imipenem ranged from 3.5 to 10.7. Although the use of carbapenems increased during the study period, there was no marked increase in resistance to carbapenems. Continuous monitoring of resistance trends is necessary so that antimicrobial prescription policies can be adjusted and infection control intervention programs can be implemented.",
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AU - Ho, Cheng Mao

AU - Ho, Mao Wang

AU - Liu, Yung Ching

AU - Toh, Han Siong

AU - Lee, Yu Lin

AU - Liu, Yuag Meng

AU - Huang, Chi Chang

AU - Lu, Po Liang

AU - Liu, Chun Eng

AU - Chen, Yen Hsu

AU - Ko, Wen Chien

AU - Tang, Hung Jen

AU - Yu, Kwok Woon

AU - Chen, Yao Shen

AU - Chuang, Yin Ching

AU - Wang, Jen Hsien

AU - Hsueh, Po Ren

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