Correlation between carbapenem consumption and resistance to carbapenems among Enterobacteriaceae isolates collected from patients with intra-abdominal infections at five medical centers in Taiwan, 2006-2010

Cheng Mao Ho, Mao Wang Ho, Yung Ching Liu, Han Siong Toh, Yu Lin Lee, Yuag Meng Liu, Chi Chang Huang, Po Liang Lu, Chun Eng Liu, Yen Hsu Chen, Wen Chien Ko, Hung Jen Tang, Kwok Woon Yu, Yao Shen Chen, Yin Ching Chuang, Jen Hsien Wang, Po Ren Hsueh

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14 Citations (Scopus)

Abstract

We investigated the trend in resistance to carbapenems among isolates of Enterobacteriaceae that had been collected from patients with intra-abdominal infections at five medical centers in Taiwan from 2006 to 2010 and evaluated the correlation between resistance to carbapenems and consumption of said agents as part of the Study for Monitoring Antimicrobial Resistance Trends (SMART). During the study period, the usage of ertapenem and that of total carbapenems (ertapenem, imipenem, and meropenem) increased significantly from 6.13 to 13.38 defined daily doses per 1000 patient-days for ertapenem and from 20.43 to 34.25 defined daily doses per 1000 patient-days for total carbapenems. The most common species were Escherichia coli (n = 1095), Klebsiella spp. (n = 663), and Enterobacter spp. (n = 202). The susceptibility of all isolates to ertapenem and to imipenem varied during the study period. For ertapenem, the rates of nonsusceptibility ranged from 3.5 to 10.3 and those for imipenem ranged from 3.5 to 10.7. Although the use of carbapenems increased during the study period, there was no marked increase in resistance to carbapenems. Continuous monitoring of resistance trends is necessary so that antimicrobial prescription policies can be adjusted and infection control intervention programs can be implemented.

Original languageEnglish
JournalInternational Journal of Antimicrobial Agents
Volume40
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Jun 2012

Keywords

  • Carbapenem consumption
  • Carbapenem resistance
  • Enterobacteriaceae
  • Intra-abdominal infections
  • SMART

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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    Ho, C. M., Ho, M. W., Liu, Y. C., Toh, H. S., Lee, Y. L., Liu, Y. M., Huang, C. C., Lu, P. L., Liu, C. E., Chen, Y. H., Ko, W. C., Tang, H. J., Yu, K. W., Chen, Y. S., Chuang, Y. C., Wang, J. H., & Hsueh, P. R. (2012). Correlation between carbapenem consumption and resistance to carbapenems among Enterobacteriaceae isolates collected from patients with intra-abdominal infections at five medical centers in Taiwan, 2006-2010. International Journal of Antimicrobial Agents, 40(SUPPL. 1). https://doi.org/10.1016/S0924-8579(12)70006-7