Correlation between bone mineral density and plasma lipids in Taiwan

Ling Yi Wu, Tsao Chin Yang, Shi Wen Kuo, Chin Fu Hsiao, Yi Jen Hung, Chang Hsun Hsieh, He Chih Tseng, An-Tsz Hsieh, Teng Wei Chen, Jin Biou Chang, Dee Pei

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Many studies showed that depression is correlated with osteoporosis, while others showed that low cholesterol level is also related to depression. However, these relationships still remain controversial. Since the bone mineral density (BMD) is related to depression and depression is related to hypocholesterolemia, there might exist a correlation between BMD and plasma cholesterol levels. To prove this, we enrolled 5000 individuals, 2170 males, and 2830 females, who had health check-ups at a private clinic between 1998 and 1999. They were divided into three groups. Group 1 was composed of male subjects; Group 2, female subjects; and Group 3, females aged over 50 to exclude pre-menopausal females. Each subject had a routine physical examination, fasting blood drawing, BMD measured by dual energy x-ray absorptiometry (DEXA) over the wrist, and was given a questionnaire to answer. Between Groups 1 and 2, the females were significantly younger, had higher body mass index (BMI), total cholesterol (TC), high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC), and platelet, but lower BMD, fasting plasma glucose (FPG), triglycerides (TG), hemoglobin (Hgb), and white blood cell (WBC) count. As for Groups 1 and 3, all the aforementioned findings still remained the same except that the systolic blood pressure (SBP) was higher and diastolic blood pressure (DBP) was lower in Group 3. Our results showed that BMD is negatively related to age in males. In females, it is negatively correlated with age, FPG, PPG, SBP, DBP, TC, LDLC, TG, and Hgb, but positively related to BMI and platelet. However, for females in Group 3, BMD is only negatively related to age, FPG, SBP, and TG but positively related to BMI. Stepwise multiple regression analysis showed that the BMD is negatively related to age but positively related to BMI in both males and females. In Group 3, BMD is negatively related to age and FPG but positively related BMI. In conclusion, no correlation exists between BMD and cholesterol. This implies that the depression is not significantly related to cholesterol and/or BMD. This might be due to various confounding factors, which could affect their relationships. The negative correlation between BMD and FPG is only observed in females older than 50 years. Further studies are needed to clarify these relationships.

Original languageEnglish
Pages (from-to)317-325
Number of pages9
JournalEndocrine Research
Volume29
Issue number3
DOIs
Publication statusPublished - Oct 7 2003
Externally publishedYes

Fingerprint

Taiwan
Bone Density
Lipids
Blood Pressure
Fasting
Cholesterol
Body Mass Index
Depression
Glucose
LDL Cholesterol
Hemoglobins
Triglycerides
Blood Platelets
Wrist
Leukocyte Count
HDL Cholesterol
Osteoporosis
Physical Examination
Regression Analysis
X-Rays

Keywords

  • Bone mineral density
  • Depression
  • Lipid

ASJC Scopus subject areas

  • Endocrinology

Cite this

Wu, L. Y., Yang, T. C., Kuo, S. W., Hsiao, C. F., Hung, Y. J., Hsieh, C. H., ... Pei, D. (2003). Correlation between bone mineral density and plasma lipids in Taiwan. Endocrine Research, 29(3), 317-325. https://doi.org/10.1081/ERC-120025039

Correlation between bone mineral density and plasma lipids in Taiwan. / Wu, Ling Yi; Yang, Tsao Chin; Kuo, Shi Wen; Hsiao, Chin Fu; Hung, Yi Jen; Hsieh, Chang Hsun; Tseng, He Chih; Hsieh, An-Tsz; Chen, Teng Wei; Chang, Jin Biou; Pei, Dee.

In: Endocrine Research, Vol. 29, No. 3, 07.10.2003, p. 317-325.

Research output: Contribution to journalArticle

Wu, LY, Yang, TC, Kuo, SW, Hsiao, CF, Hung, YJ, Hsieh, CH, Tseng, HC, Hsieh, A-T, Chen, TW, Chang, JB & Pei, D 2003, 'Correlation between bone mineral density and plasma lipids in Taiwan', Endocrine Research, vol. 29, no. 3, pp. 317-325. https://doi.org/10.1081/ERC-120025039
Wu LY, Yang TC, Kuo SW, Hsiao CF, Hung YJ, Hsieh CH et al. Correlation between bone mineral density and plasma lipids in Taiwan. Endocrine Research. 2003 Oct 7;29(3):317-325. https://doi.org/10.1081/ERC-120025039
Wu, Ling Yi ; Yang, Tsao Chin ; Kuo, Shi Wen ; Hsiao, Chin Fu ; Hung, Yi Jen ; Hsieh, Chang Hsun ; Tseng, He Chih ; Hsieh, An-Tsz ; Chen, Teng Wei ; Chang, Jin Biou ; Pei, Dee. / Correlation between bone mineral density and plasma lipids in Taiwan. In: Endocrine Research. 2003 ; Vol. 29, No. 3. pp. 317-325.
@article{afd352fe0b5048e9851fe549c721747e,
title = "Correlation between bone mineral density and plasma lipids in Taiwan",
abstract = "Many studies showed that depression is correlated with osteoporosis, while others showed that low cholesterol level is also related to depression. However, these relationships still remain controversial. Since the bone mineral density (BMD) is related to depression and depression is related to hypocholesterolemia, there might exist a correlation between BMD and plasma cholesterol levels. To prove this, we enrolled 5000 individuals, 2170 males, and 2830 females, who had health check-ups at a private clinic between 1998 and 1999. They were divided into three groups. Group 1 was composed of male subjects; Group 2, female subjects; and Group 3, females aged over 50 to exclude pre-menopausal females. Each subject had a routine physical examination, fasting blood drawing, BMD measured by dual energy x-ray absorptiometry (DEXA) over the wrist, and was given a questionnaire to answer. Between Groups 1 and 2, the females were significantly younger, had higher body mass index (BMI), total cholesterol (TC), high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC), and platelet, but lower BMD, fasting plasma glucose (FPG), triglycerides (TG), hemoglobin (Hgb), and white blood cell (WBC) count. As for Groups 1 and 3, all the aforementioned findings still remained the same except that the systolic blood pressure (SBP) was higher and diastolic blood pressure (DBP) was lower in Group 3. Our results showed that BMD is negatively related to age in males. In females, it is negatively correlated with age, FPG, PPG, SBP, DBP, TC, LDLC, TG, and Hgb, but positively related to BMI and platelet. However, for females in Group 3, BMD is only negatively related to age, FPG, SBP, and TG but positively related to BMI. Stepwise multiple regression analysis showed that the BMD is negatively related to age but positively related to BMI in both males and females. In Group 3, BMD is negatively related to age and FPG but positively related BMI. In conclusion, no correlation exists between BMD and cholesterol. This implies that the depression is not significantly related to cholesterol and/or BMD. This might be due to various confounding factors, which could affect their relationships. The negative correlation between BMD and FPG is only observed in females older than 50 years. Further studies are needed to clarify these relationships.",
keywords = "Bone mineral density, Depression, Lipid",
author = "Wu, {Ling Yi} and Yang, {Tsao Chin} and Kuo, {Shi Wen} and Hsiao, {Chin Fu} and Hung, {Yi Jen} and Hsieh, {Chang Hsun} and Tseng, {He Chih} and An-Tsz Hsieh and Chen, {Teng Wei} and Chang, {Jin Biou} and Dee Pei",
year = "2003",
month = "10",
day = "7",
doi = "10.1081/ERC-120025039",
language = "English",
volume = "29",
pages = "317--325",
journal = "Endocrine Research",
issn = "0743-5800",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - Correlation between bone mineral density and plasma lipids in Taiwan

AU - Wu, Ling Yi

AU - Yang, Tsao Chin

AU - Kuo, Shi Wen

AU - Hsiao, Chin Fu

AU - Hung, Yi Jen

AU - Hsieh, Chang Hsun

AU - Tseng, He Chih

AU - Hsieh, An-Tsz

AU - Chen, Teng Wei

AU - Chang, Jin Biou

AU - Pei, Dee

PY - 2003/10/7

Y1 - 2003/10/7

N2 - Many studies showed that depression is correlated with osteoporosis, while others showed that low cholesterol level is also related to depression. However, these relationships still remain controversial. Since the bone mineral density (BMD) is related to depression and depression is related to hypocholesterolemia, there might exist a correlation between BMD and plasma cholesterol levels. To prove this, we enrolled 5000 individuals, 2170 males, and 2830 females, who had health check-ups at a private clinic between 1998 and 1999. They were divided into three groups. Group 1 was composed of male subjects; Group 2, female subjects; and Group 3, females aged over 50 to exclude pre-menopausal females. Each subject had a routine physical examination, fasting blood drawing, BMD measured by dual energy x-ray absorptiometry (DEXA) over the wrist, and was given a questionnaire to answer. Between Groups 1 and 2, the females were significantly younger, had higher body mass index (BMI), total cholesterol (TC), high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC), and platelet, but lower BMD, fasting plasma glucose (FPG), triglycerides (TG), hemoglobin (Hgb), and white blood cell (WBC) count. As for Groups 1 and 3, all the aforementioned findings still remained the same except that the systolic blood pressure (SBP) was higher and diastolic blood pressure (DBP) was lower in Group 3. Our results showed that BMD is negatively related to age in males. In females, it is negatively correlated with age, FPG, PPG, SBP, DBP, TC, LDLC, TG, and Hgb, but positively related to BMI and platelet. However, for females in Group 3, BMD is only negatively related to age, FPG, SBP, and TG but positively related to BMI. Stepwise multiple regression analysis showed that the BMD is negatively related to age but positively related to BMI in both males and females. In Group 3, BMD is negatively related to age and FPG but positively related BMI. In conclusion, no correlation exists between BMD and cholesterol. This implies that the depression is not significantly related to cholesterol and/or BMD. This might be due to various confounding factors, which could affect their relationships. The negative correlation between BMD and FPG is only observed in females older than 50 years. Further studies are needed to clarify these relationships.

AB - Many studies showed that depression is correlated with osteoporosis, while others showed that low cholesterol level is also related to depression. However, these relationships still remain controversial. Since the bone mineral density (BMD) is related to depression and depression is related to hypocholesterolemia, there might exist a correlation between BMD and plasma cholesterol levels. To prove this, we enrolled 5000 individuals, 2170 males, and 2830 females, who had health check-ups at a private clinic between 1998 and 1999. They were divided into three groups. Group 1 was composed of male subjects; Group 2, female subjects; and Group 3, females aged over 50 to exclude pre-menopausal females. Each subject had a routine physical examination, fasting blood drawing, BMD measured by dual energy x-ray absorptiometry (DEXA) over the wrist, and was given a questionnaire to answer. Between Groups 1 and 2, the females were significantly younger, had higher body mass index (BMI), total cholesterol (TC), high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC), and platelet, but lower BMD, fasting plasma glucose (FPG), triglycerides (TG), hemoglobin (Hgb), and white blood cell (WBC) count. As for Groups 1 and 3, all the aforementioned findings still remained the same except that the systolic blood pressure (SBP) was higher and diastolic blood pressure (DBP) was lower in Group 3. Our results showed that BMD is negatively related to age in males. In females, it is negatively correlated with age, FPG, PPG, SBP, DBP, TC, LDLC, TG, and Hgb, but positively related to BMI and platelet. However, for females in Group 3, BMD is only negatively related to age, FPG, SBP, and TG but positively related to BMI. Stepwise multiple regression analysis showed that the BMD is negatively related to age but positively related to BMI in both males and females. In Group 3, BMD is negatively related to age and FPG but positively related BMI. In conclusion, no correlation exists between BMD and cholesterol. This implies that the depression is not significantly related to cholesterol and/or BMD. This might be due to various confounding factors, which could affect their relationships. The negative correlation between BMD and FPG is only observed in females older than 50 years. Further studies are needed to clarify these relationships.

KW - Bone mineral density

KW - Depression

KW - Lipid

UR - http://www.scopus.com/inward/record.url?scp=10744224718&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10744224718&partnerID=8YFLogxK

U2 - 10.1081/ERC-120025039

DO - 10.1081/ERC-120025039

M3 - Article

C2 - 14535633

AN - SCOPUS:10744224718

VL - 29

SP - 317

EP - 325

JO - Endocrine Research

JF - Endocrine Research

SN - 0743-5800

IS - 3

ER -