Correction of malignant behavior of tumor cells by traditional Chinese herb medicine through a restoration of p53

Win Ping Deng, Ming Wei Chao, Wen-FuThomas Lai, Chi Sun, Chen Yen Chung, Cheng Chia Wu, I. Hsin Lin, Jeng Jong Hwang, Chih Hsiung Wu, Wen Ta Chiu, Chia Yu Chen, John Leslie Redpath

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We have previously demonstrated that a UVC-induced tumorigenic HeLa x skin fibroblast cell line could be induced to form a more normal phenotypic state ('reversion'), including loss of IAP expression. We have now used the loss of IAP expression to monitor the enhancement of this reversion in the cervical cancer cell line, HeLa, by a traditional Chinese herb medicine (TCM), Yigan Kang (YGK). IAP level decreased, and the reversion frequency increased, in a dose-dependent manner at concentrations of YGK of more than 10 mg. YGK significantly repressed E6/E7 oncogenes at the transcriptional level, with subsequent reactivation of p53 and p21 expression (P

Original languageEnglish
Pages (from-to)315-327
Number of pages13
JournalCancer Letters
Volume233
Issue number2
DOIs
Publication statusPublished - Feb 28 2006

Keywords

  • Cancer reversion
  • HPV
  • IAP
  • p53
  • TCM
  • Yigan Kang

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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  • Cite this

    Deng, W. P., Chao, M. W., Lai, W-F., Sun, C., Chung, C. Y., Wu, C. C., Lin, I. H., Hwang, J. J., Wu, C. H., Chiu, W. T., Chen, C. Y., & Redpath, J. L. (2006). Correction of malignant behavior of tumor cells by traditional Chinese herb medicine through a restoration of p53. Cancer Letters, 233(2), 315-327. https://doi.org/10.1016/j.canlet.2005.03.031