Correcting for non-compliance bias in case-control studies to evaluate cancer screening programmes

Stephen W. Duffy, Jack Cuzick, Laszlo Tabar, Bedrich Vitak, Tony Hsiu Hsi Chen, Ming Fang Yen, Robert A. Smith

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

In the evaluation of uncontrolled service screening programmes for cancer, the case-control design is sometimes used, in which people who die from the disease in question are compared with live controls with respect to screening histories. Such a design tends to yield estimates of relative mortality in voluntary participants compared with non-participants. This may bias results, since compilers and non-compilers may differ a priori in ways which are not related to screening but which nevertheless affect the risk of death from the disease. We present a simple method, employing external data from previously published randomized controlled trials of screening, of correction for this bias. We illustrate it by using data from a case-control study performed within the invited arm of the Malmö mammographic screening trial, a prospective study from the service screening programme in two counties in Sweden, and a matched case-control study of mammographic screening in Florence, Italy.

Original languageEnglish
Pages (from-to)235-243
Number of pages9
JournalJournal of the Royal Statistical Society. Series C: Applied Statistics
Volume51
Issue number2
DOIs
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Noncompliance
Case-control Study
Screening
Cancer
Evaluate
Matched Case-control Study
Randomized Controlled Trial
Case-control
Sweden
Cancer screening
Control Design
Mortality
Compiler
Die
Tend
Evaluation
Estimate

Keywords

  • Cancer screening
  • Case-control study
  • Selection bias

ASJC Scopus subject areas

  • Mathematics(all)
  • Statistics and Probability

Cite this

Correcting for non-compliance bias in case-control studies to evaluate cancer screening programmes. / Duffy, Stephen W.; Cuzick, Jack; Tabar, Laszlo; Vitak, Bedrich; Chen, Tony Hsiu Hsi; Yen, Ming Fang; Smith, Robert A.

In: Journal of the Royal Statistical Society. Series C: Applied Statistics, Vol. 51, No. 2, 2002, p. 235-243.

Research output: Contribution to journalArticle

Duffy, Stephen W. ; Cuzick, Jack ; Tabar, Laszlo ; Vitak, Bedrich ; Chen, Tony Hsiu Hsi ; Yen, Ming Fang ; Smith, Robert A. / Correcting for non-compliance bias in case-control studies to evaluate cancer screening programmes. In: Journal of the Royal Statistical Society. Series C: Applied Statistics. 2002 ; Vol. 51, No. 2. pp. 235-243.
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