Abstract
Background: Left ventricular (LV) diastolic dysfunction is known as an early marker of myocardial alterations in patients with diabetes. Because microvascular disease has been regarded as an important cause of heart failure or diastolic dysfunction in diabetic patients, we tested the hypothesis that coronary flow reserve (CFR), which reflects coronary microvascular function, is associated with LV diastolic dysfunction in patients with type 2 diabetes. Methods: We studied asymptomatic patients with type 2 diabetes but without overt heart failure. Transthoracic Doppler echocardiography was performed that included pulsed tissue Doppler of the mitral annulus and CFR of the left anterior descending artery (induced by adenosine 0.14mg/kg/min). The ratio of mitral velocity to early diastolic velocity of the mitral annulus (E/e') was used as a surrogate marker of diastolic function. We also evaluated renal function, lipid profile, parameters of glycemic control and other clinical characteristics to determine their association with E/e'. Patients with LV ejection fraction 2.0mg/dl) or type 1 diabetes were excluded. Patients with a CFR
| Original language | English |
|---|---|
| Article number | 98 |
| Journal | Cardiovascular Diabetology |
| Volume | 14 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Aug 5 2015 |
| Externally published | Yes |
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Keywords
- Coronary flow reserve
- Diastolic dysfunction
- Microvascular disease
- Type 2 diabetes mellitus
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Endocrinology, Diabetes and Metabolism
Cite this
Coronary microvascular function is independently associated with left ventricular filling pressure in patients with type 2 diabetes mellitus. / Kawata, Takayuki; Daimon, Masao; Miyazaki, Sakiko; Ichikawa, Ryoko; Maruyama, Masaki; Chiang, Shuo Ju; Ito, Chiharu; Sato, Fumihiko; Watada, Hirotaka; Daida, Hiroyuki.
In: Cardiovascular Diabetology, Vol. 14, No. 1, 98, 05.08.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Coronary microvascular function is independently associated with left ventricular filling pressure in patients with type 2 diabetes mellitus
AU - Kawata, Takayuki
AU - Daimon, Masao
AU - Miyazaki, Sakiko
AU - Ichikawa, Ryoko
AU - Maruyama, Masaki
AU - Chiang, Shuo Ju
AU - Ito, Chiharu
AU - Sato, Fumihiko
AU - Watada, Hirotaka
AU - Daida, Hiroyuki
PY - 2015/8/5
Y1 - 2015/8/5
N2 - Background: Left ventricular (LV) diastolic dysfunction is known as an early marker of myocardial alterations in patients with diabetes. Because microvascular disease has been regarded as an important cause of heart failure or diastolic dysfunction in diabetic patients, we tested the hypothesis that coronary flow reserve (CFR), which reflects coronary microvascular function, is associated with LV diastolic dysfunction in patients with type 2 diabetes. Methods: We studied asymptomatic patients with type 2 diabetes but without overt heart failure. Transthoracic Doppler echocardiography was performed that included pulsed tissue Doppler of the mitral annulus and CFR of the left anterior descending artery (induced by adenosine 0.14mg/kg/min). The ratio of mitral velocity to early diastolic velocity of the mitral annulus (E/e') was used as a surrogate marker of diastolic function. We also evaluated renal function, lipid profile, parameters of glycemic control and other clinical characteristics to determine their association with E/e'. Patients with LV ejection fraction 2.0mg/dl) or type 1 diabetes were excluded. Patients with a CFR
AB - Background: Left ventricular (LV) diastolic dysfunction is known as an early marker of myocardial alterations in patients with diabetes. Because microvascular disease has been regarded as an important cause of heart failure or diastolic dysfunction in diabetic patients, we tested the hypothesis that coronary flow reserve (CFR), which reflects coronary microvascular function, is associated with LV diastolic dysfunction in patients with type 2 diabetes. Methods: We studied asymptomatic patients with type 2 diabetes but without overt heart failure. Transthoracic Doppler echocardiography was performed that included pulsed tissue Doppler of the mitral annulus and CFR of the left anterior descending artery (induced by adenosine 0.14mg/kg/min). The ratio of mitral velocity to early diastolic velocity of the mitral annulus (E/e') was used as a surrogate marker of diastolic function. We also evaluated renal function, lipid profile, parameters of glycemic control and other clinical characteristics to determine their association with E/e'. Patients with LV ejection fraction 2.0mg/dl) or type 1 diabetes were excluded. Patients with a CFR
KW - Coronary flow reserve
KW - Diastolic dysfunction
KW - Microvascular disease
KW - Type 2 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=84939427151&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84939427151&partnerID=8YFLogxK
U2 - 10.1186/s12933-015-0263-7
DO - 10.1186/s12933-015-0263-7
M3 - Article
C2 - 26242308
AN - SCOPUS:84939427151
VL - 14
JO - Cardiovascular Diabetology
JF - Cardiovascular Diabetology
SN - 1475-2840
IS - 1
M1 - 98
ER -