Coronary artery spasm: Review and update

Ming Jui Hung, Patrick Hu, Ming Yow Hung

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Coronary artery spasm (CAS), an intense vasoconstriction of coronary arteries that causes total or subtotal vessel occlusion, plays an important role in myocardial ischemic syndromes including stable and unstable angina, acute myocardial infarction, and sudden cardiac death. Coronary angiography and provocative testing usually is required to establish a definitive diagnosis. While the mechanisms underlying the development of CAS are still poorly understood, CAS appears to be a multifactorial disease but is not associated with the traditional risk factors for coronary artery disease. The diagnosis of CAS has important therapeutic implications, as calcium antagonists, not β-blockers, are the cornerstone of medical treatment. The prognosis is generally considered benign; however, recurrent episodes of angina are frequently observed. We provide a review of the literature and summarize the current state of knowledge regarding the pathogenesis of CAS.

Original languageEnglish
Pages (from-to)1161-1171
Number of pages11
JournalInternational Journal of Medical Sciences
Volume11
Issue number11
DOIs
Publication statusPublished - Aug 28 2014

Fingerprint

Spasm
Coronary Vessels
Stable Angina
Sudden Cardiac Death
Unstable Angina
Vasoconstriction
Coronary Angiography
Coronary Artery Disease
Myocardial Infarction
Calcium
Therapeutics

Keywords

  • Coronary artery spasm
  • Prinzmetal's angina
  • Provocative testing

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Coronary artery spasm : Review and update. / Hung, Ming Jui; Hu, Patrick; Hung, Ming Yow.

In: International Journal of Medical Sciences, Vol. 11, No. 11, 28.08.2014, p. 1161-1171.

Research output: Contribution to journalArticle

Hung, Ming Jui ; Hu, Patrick ; Hung, Ming Yow. / Coronary artery spasm : Review and update. In: International Journal of Medical Sciences. 2014 ; Vol. 11, No. 11. pp. 1161-1171.
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