Coronary artery calcium determined by electron beam computed tomography for predicting angiographic coronary artery disease in moderate- to high-risk Chinese patients

Lung Ching Chen, Philip Yu An Ding, Jaw Wen Chen, Mei Han Wu, Ju Chi Liu, Gong Yau Lan, Ming Sheng Chern, Cheng Yen Chang, Mau Song Chang

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The aim of this study was to evaluate the prevalence of coronary calcification among moderate- to high-risk Chinese patients and to evaluate the ability of the coronary calcium score determined by electron beam computed tomography (EBCT) to predict angiographic coronary artery disease in this population. We enrolled 163 consecutive patients and analyzed their cardiovascular risk factors, coronary calcium scores and coronary angiogram results. One hundred and twenty-five patients (76.7%) had a positive EBCT scan result (coronary calcium score >0). The prevalence of calcification and the calcium scores showed a graded relation to the number of cardiovascular risk factors and age (p <0.001 for trend). Coronary calcium scores showed statistically significant differences between patients with angiographic evidence of coronary artery disease and patients with normal coronary angiography (p <0.05), but could not differentiate between patients with significant and insignificant coronary artery disease. Receiver operating characteristic curve analysis showed that a coronary calcium score >5 predicted angiographic coronary artery disease with 93% sensitivity and 86% specificity (area under the curve 0.95 ± 0.019). Multivariate analysis showed a coronary calcium score >5 to be the strongest independent predictor of angiographic coronary artery disease (odds ratio 120.7, 95% confidence interval 21.7-671.4; p <0.001). Coronary calcium score determined by EBCT appears to have a similar predictive value in Chinese patients as it does in other ethnic populations that have been reported to date.

Original languageEnglish
Pages (from-to)183-189
Number of pages7
JournalCardiology
Volume95
Issue number4
DOIs
Publication statusPublished - 2001

Fingerprint

X Ray Computed Tomography
Coronary Artery Disease
Coronary Vessels
Calcium
Population
Area Under Curve
Angiography
Multivariate Analysis
Odds Ratio
Confidence Intervals
Sensitivity and Specificity

Keywords

  • Coronary artery disease
  • Coronary calcification
  • Electron beam computed tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Coronary artery calcium determined by electron beam computed tomography for predicting angiographic coronary artery disease in moderate- to high-risk Chinese patients. / Chen, Lung Ching; Ding, Philip Yu An; Chen, Jaw Wen; Wu, Mei Han; Liu, Ju Chi; Lan, Gong Yau; Chern, Ming Sheng; Chang, Cheng Yen; Chang, Mau Song.

In: Cardiology, Vol. 95, No. 4, 2001, p. 183-189.

Research output: Contribution to journalArticle

Chen, Lung Ching ; Ding, Philip Yu An ; Chen, Jaw Wen ; Wu, Mei Han ; Liu, Ju Chi ; Lan, Gong Yau ; Chern, Ming Sheng ; Chang, Cheng Yen ; Chang, Mau Song. / Coronary artery calcium determined by electron beam computed tomography for predicting angiographic coronary artery disease in moderate- to high-risk Chinese patients. In: Cardiology. 2001 ; Vol. 95, No. 4. pp. 183-189.
@article{f26ee9418eb84c5e97dd9b691e9d7a0c,
title = "Coronary artery calcium determined by electron beam computed tomography for predicting angiographic coronary artery disease in moderate- to high-risk Chinese patients",
abstract = "The aim of this study was to evaluate the prevalence of coronary calcification among moderate- to high-risk Chinese patients and to evaluate the ability of the coronary calcium score determined by electron beam computed tomography (EBCT) to predict angiographic coronary artery disease in this population. We enrolled 163 consecutive patients and analyzed their cardiovascular risk factors, coronary calcium scores and coronary angiogram results. One hundred and twenty-five patients (76.7{\%}) had a positive EBCT scan result (coronary calcium score >0). The prevalence of calcification and the calcium scores showed a graded relation to the number of cardiovascular risk factors and age (p <0.001 for trend). Coronary calcium scores showed statistically significant differences between patients with angiographic evidence of coronary artery disease and patients with normal coronary angiography (p <0.05), but could not differentiate between patients with significant and insignificant coronary artery disease. Receiver operating characteristic curve analysis showed that a coronary calcium score >5 predicted angiographic coronary artery disease with 93{\%} sensitivity and 86{\%} specificity (area under the curve 0.95 ± 0.019). Multivariate analysis showed a coronary calcium score >5 to be the strongest independent predictor of angiographic coronary artery disease (odds ratio 120.7, 95{\%} confidence interval 21.7-671.4; p <0.001). Coronary calcium score determined by EBCT appears to have a similar predictive value in Chinese patients as it does in other ethnic populations that have been reported to date.",
keywords = "Coronary artery disease, Coronary calcification, Electron beam computed tomography, Coronary artery disease, Coronary calcification, Electron beam computed tomography",
author = "Chen, {Lung Ching} and Ding, {Philip Yu An} and Chen, {Jaw Wen} and Wu, {Mei Han} and Liu, {Ju Chi} and Lan, {Gong Yau} and Chern, {Ming Sheng} and Chang, {Cheng Yen} and Chang, {Mau Song}",
year = "2001",
doi = "10.1159/000047370",
language = "English",
volume = "95",
pages = "183--189",
journal = "Cardiology",
issn = "0008-6312",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Coronary artery calcium determined by electron beam computed tomography for predicting angiographic coronary artery disease in moderate- to high-risk Chinese patients

AU - Chen, Lung Ching

AU - Ding, Philip Yu An

AU - Chen, Jaw Wen

AU - Wu, Mei Han

AU - Liu, Ju Chi

AU - Lan, Gong Yau

AU - Chern, Ming Sheng

AU - Chang, Cheng Yen

AU - Chang, Mau Song

PY - 2001

Y1 - 2001

N2 - The aim of this study was to evaluate the prevalence of coronary calcification among moderate- to high-risk Chinese patients and to evaluate the ability of the coronary calcium score determined by electron beam computed tomography (EBCT) to predict angiographic coronary artery disease in this population. We enrolled 163 consecutive patients and analyzed their cardiovascular risk factors, coronary calcium scores and coronary angiogram results. One hundred and twenty-five patients (76.7%) had a positive EBCT scan result (coronary calcium score >0). The prevalence of calcification and the calcium scores showed a graded relation to the number of cardiovascular risk factors and age (p <0.001 for trend). Coronary calcium scores showed statistically significant differences between patients with angiographic evidence of coronary artery disease and patients with normal coronary angiography (p <0.05), but could not differentiate between patients with significant and insignificant coronary artery disease. Receiver operating characteristic curve analysis showed that a coronary calcium score >5 predicted angiographic coronary artery disease with 93% sensitivity and 86% specificity (area under the curve 0.95 ± 0.019). Multivariate analysis showed a coronary calcium score >5 to be the strongest independent predictor of angiographic coronary artery disease (odds ratio 120.7, 95% confidence interval 21.7-671.4; p <0.001). Coronary calcium score determined by EBCT appears to have a similar predictive value in Chinese patients as it does in other ethnic populations that have been reported to date.

AB - The aim of this study was to evaluate the prevalence of coronary calcification among moderate- to high-risk Chinese patients and to evaluate the ability of the coronary calcium score determined by electron beam computed tomography (EBCT) to predict angiographic coronary artery disease in this population. We enrolled 163 consecutive patients and analyzed their cardiovascular risk factors, coronary calcium scores and coronary angiogram results. One hundred and twenty-five patients (76.7%) had a positive EBCT scan result (coronary calcium score >0). The prevalence of calcification and the calcium scores showed a graded relation to the number of cardiovascular risk factors and age (p <0.001 for trend). Coronary calcium scores showed statistically significant differences between patients with angiographic evidence of coronary artery disease and patients with normal coronary angiography (p <0.05), but could not differentiate between patients with significant and insignificant coronary artery disease. Receiver operating characteristic curve analysis showed that a coronary calcium score >5 predicted angiographic coronary artery disease with 93% sensitivity and 86% specificity (area under the curve 0.95 ± 0.019). Multivariate analysis showed a coronary calcium score >5 to be the strongest independent predictor of angiographic coronary artery disease (odds ratio 120.7, 95% confidence interval 21.7-671.4; p <0.001). Coronary calcium score determined by EBCT appears to have a similar predictive value in Chinese patients as it does in other ethnic populations that have been reported to date.

KW - Coronary artery disease

KW - Coronary calcification

KW - Electron beam computed tomography

KW - Coronary artery disease

KW - Coronary calcification

KW - Electron beam computed tomography

UR - http://www.scopus.com/inward/record.url?scp=0035741832&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035741832&partnerID=8YFLogxK

U2 - 10.1159/000047370

DO - 10.1159/000047370

M3 - Article

C2 - 11585993

AN - SCOPUS:0035741832

VL - 95

SP - 183

EP - 189

JO - Cardiology

JF - Cardiology

SN - 0008-6312

IS - 4

ER -