Coronary artery aneurysms occurrence risk analysis between Kawasaki disease and LRP1B gene in Taiwanese children

Ying Ju Lin, Xiang Liu, Jeng Sheng Chang, Wen Kuei Chien, Jin Hua Chen, Hsinyi Tsang, Chien Hui Hung, Ting Hsu Lin, Shao Mei Huang, Chiu Chu Liao, Cheng Wen Lin, Tsung Jung Ho, Fuu Jen Tsai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Kawasaki disease (KD) is an acute and systemic vasculitis. Its complications in coronary artery aneurysms (CAA) make KD one of the leading causes of acquired cardiovascular diseases in childhood. Low density lipoprotein receptor-related protein 1B (LRP1B) is abundantly expressed in the medial layer of coronary arteries and involved in endothelium inflammations. Purpose: We aimed to identify the role of LRP1B in CAA formation during KD progression. Methods: we investigated genetic variations in LRP1B in a Taiwanese cohort of 258 KD patients (83 with CAA and 175 without CAA complications). We used univariate and multivariate regression analyses to identify the associations between LRP1B genetic variations and KD patients. Results: CAA formation in KD was significantly associated with the LRP1B (rs6707826) genetic variant (p = 0.007). By using multivariate regression analysis, significant correlations were observed between KD with CAA complications and the presence of the TT+TG genotypes for the LRP1B rs6707826 single-nucleotide polymorphism (full model: odds ratio = 2.82; 95% CI = 1.33-5.78). Conclusion: Our results suggest that genetic polymorphism of LRP1B gene may be used as a genetic marker for the diagnosis and prognosis of the CAA formation in KD and contribute to genetic profiling studies for personalized medicine.

Original languageEnglish
Pages (from-to)18-22
Number of pages5
JournalBioMedicine (Netherlands)
Volume4
Issue number2
DOIs
Publication statusPublished - Jun 1 2014

Keywords

  • CAA
  • KD
  • LRP1B
  • Single-nucleotide polymorphism

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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    Lin, Y. J., Liu, X., Chang, J. S., Chien, W. K., Chen, J. H., Tsang, H., Hung, C. H., Lin, T. H., Huang, S. M., Liao, C. C., Lin, C. W., Ho, T. J., & Tsai, F. J. (2014). Coronary artery aneurysms occurrence risk analysis between Kawasaki disease and LRP1B gene in Taiwanese children. BioMedicine (Netherlands), 4(2), 18-22. https://doi.org/10.7603/s40681-014-0010-5