Cornu Cervi Pantotrichum supplementation improves exercise performance and protects against physical fatigue in Mice

Chi Chang Huang, Yi Ming Chen, Nai Wen Kan, Hui Ling Chao, Chin Shan Ho, Mei Chich Hsu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Cornu cervi pantotrichum (CCP) is a well-known yang-invigorating agent used in traditional Chinese medicine that can nourish the blood, tonify qi, and invigorate bones and tendons with multifunctional bioactivities. However, evidence on the effects of CCP on exercise performance and physical fatigue is limited. We evaluated the potential beneficial effects of ethanolic extract from CCP on ergogenic and antifatigue functions following a physiological challenge. Male ICR mice from four groups (n = 8 per group) were orally administered CCP for 14 days at 0, 2054, and 4108 mg/kg/day, and were respectively designated as the vehicle, CCP-1X, and CCP-2X groups. The physical performance and antifatigue function were evaluated using forelimb grip strength and exhaustive swimming time as well as serum levels of lactate, ammonia, glucose, and creatine kinase after a 15-min swimming exercise. The results indicated that CCP-1X supplementation significantly improved grip strength; reduced fatigue-associated biochemical indices, including lactate and ammonia levels; and ameliorated skeletal muscle injury induced by acute exercise challenge. A trend analysis revealed that CCP supplementation significantly increased grip strength and dose-dependently reduced serum alkaline phosphatase, uric acid, triacylglycerol, and glucose levels in healthy mice. Therefore, CCP is a potential agent with an antifatigue pharmacological effect.

Original languageEnglish
Pages (from-to)4669-4680
Number of pages12
JournalMolecules
Volume19
Issue number4
DOIs
Publication statusPublished - 2014

Fingerprint

Hand Strength
physical exercise
Ammonia
Fatigue
mice
Lactic Acid
lactates
Fatigue of materials
Glucose
glucose
serums
ammonia
Tendons
Creatine Kinase
Bioactivity
Uric Acid
creatine
trend analysis
Exercise
Medicine

Keywords

  • Antifatigue
  • Deer antler
  • Grip strength

ASJC Scopus subject areas

  • Organic Chemistry
  • Medicine(all)

Cite this

Cornu Cervi Pantotrichum supplementation improves exercise performance and protects against physical fatigue in Mice. / Huang, Chi Chang; Chen, Yi Ming; Kan, Nai Wen; Chao, Hui Ling; Ho, Chin Shan; Hsu, Mei Chich.

In: Molecules, Vol. 19, No. 4, 2014, p. 4669-4680.

Research output: Contribution to journalArticle

Huang, Chi Chang ; Chen, Yi Ming ; Kan, Nai Wen ; Chao, Hui Ling ; Ho, Chin Shan ; Hsu, Mei Chich. / Cornu Cervi Pantotrichum supplementation improves exercise performance and protects against physical fatigue in Mice. In: Molecules. 2014 ; Vol. 19, No. 4. pp. 4669-4680.
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