Abstract

Diabetic nephropathy is derived from long-term effects of high blood glucose on kidney function in type 2 diabetic patients. Several antidiabetic drugs and herbal medications have failed to prevent episodes of DN. Hence, this study aimed to further investigate the renal injury-reducing effect of antidiabetic CmNo1, a novel combination of powders of fruiting bodies and mycelia of Cordyceps militaris. After being administered with streptozotocin-nicotinamide and high-fat-diet, the diabetic nephropathy mouse model displayed elevated blood glucose and renal dysfunction markers including serum creatinine and kidney-to-body weight ratio. These elevated markers were significantly mitigated following 8 weeks CmNo1 treatment. Moreover, the chronic hyperglycemia-induced pathological alteration in renal tissue were also ameliorated. Besides, immunohistochemical study demonstrated a substantial reduction in elevated levels of carboxymethyl lysine, an advanced glycation end product. Elevated collagenous deposition in DN group was also attenuated through CmNo1 administration. Moreover, the enhanced levels of transforming growth factor-β1, a fibrosis-inducing protein in glomerulus were also markedly dampened. Furthermore, auxiliary risk factors in DN like serum triglycerides and cholesterol were found to be increased but were decreased by CmNo1 treatment. Conclusively, the results suggests that CmNo1 exhibit potent and efficacious renoprotective action against hyperglycemia-induced DN.

Original languageEnglish
Article numbere0166342
JournalPLoS One
Volume11
Issue number11
DOIs
Publication statusPublished - Nov 1 2016

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Cordyceps militaris
Cordyceps
diabetic nephropathy
Diabetic Nephropathies
renal function
Hypoglycemic Agents
preserves
Blood Glucose
kidneys
Kidney
Advanced Glycosylation End Products
Niacinamide
mice
Transforming Growth Factors
hyperglycemia
Nutrition
Streptozocin
Powders
blood glucose
Creatinine

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Cordyceps militaris treatment preserves renal function in type 2 diabetic nephropathy mice. / Yu, Sung Hsun; Dubey, Navneet Kumar; Li, Wei Shan; Liu, Ming Che; Chiang, Han Sun; Leu, Sy Jye; Shieh, Ying Hua; Tsai, Feng Chou; Deng, Win Ping.

In: PLoS One, Vol. 11, No. 11, e0166342, 01.11.2016.

Research output: Contribution to journalArticle

Yu, Sung Hsun ; Dubey, Navneet Kumar ; Li, Wei Shan ; Liu, Ming Che ; Chiang, Han Sun ; Leu, Sy Jye ; Shieh, Ying Hua ; Tsai, Feng Chou ; Deng, Win Ping. / Cordyceps militaris treatment preserves renal function in type 2 diabetic nephropathy mice. In: PLoS One. 2016 ; Vol. 11, No. 11.
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abstract = "Diabetic nephropathy is derived from long-term effects of high blood glucose on kidney function in type 2 diabetic patients. Several antidiabetic drugs and herbal medications have failed to prevent episodes of DN. Hence, this study aimed to further investigate the renal injury-reducing effect of antidiabetic CmNo1, a novel combination of powders of fruiting bodies and mycelia of Cordyceps militaris. After being administered with streptozotocin-nicotinamide and high-fat-diet, the diabetic nephropathy mouse model displayed elevated blood glucose and renal dysfunction markers including serum creatinine and kidney-to-body weight ratio. These elevated markers were significantly mitigated following 8 weeks CmNo1 treatment. Moreover, the chronic hyperglycemia-induced pathological alteration in renal tissue were also ameliorated. Besides, immunohistochemical study demonstrated a substantial reduction in elevated levels of carboxymethyl lysine, an advanced glycation end product. Elevated collagenous deposition in DN group was also attenuated through CmNo1 administration. Moreover, the enhanced levels of transforming growth factor-β1, a fibrosis-inducing protein in glomerulus were also markedly dampened. Furthermore, auxiliary risk factors in DN like serum triglycerides and cholesterol were found to be increased but were decreased by CmNo1 treatment. Conclusively, the results suggests that CmNo1 exhibit potent and efficacious renoprotective action against hyperglycemia-induced DN.",
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