Cordycepin suppressed lipid accumulation via regulating AMPK activity and mitochondrial fusion in hepatocytes

Wu-Ching Uen, Yeu-Ching Shi, Chen-Yen Choong, Cheng-Jeng Tai

Research output: Contribution to journalArticle

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Abstract

Abstract Compound cordycepin (3?-deoxyadenosine) has been used in cancer treatment, diabetes prevention, and anti-virus, as well as hyperlipidemia downregulation in vivo. However, the association between lipid metabolism and mitochondrial activity in cordycepin-treated hepatocytes is remain unclear. In this study, whether cordycepin affects lipogenesis and fatty beta-oxidation through regulating mitochondrial activity and AMP-activated protein kinase (AMPK) in hepatocytes were investigated. The data showed that cordycepin decreased lipid accumulation via activating AMPK and regulating mitochondrial function in oleic acid (OA)-induced mouse FL83B hepatocytes while the anti-fatty liver effect of cordycepin on regulating lipogenesis and fatty beta-oxidation was abolished by AMPK inhibitor compound C treatment. These results suggested that cordycepin attenuated lipid accumulation through promoting beta-oxidation and may be developed as a functional food/natural medicine for fatty liver suppression. Practical applications Traditional herb, Chinese medicine, and functional food treatments for hyperlipidemia are relatively cheap and locally available. The results of this study suggested that cordycepin (active compound of Cordyceps) may be developed as functional foods for fatty liver treatment via regulating fatty beta-oxidation.
Original languageTraditional Chinese
Pages (from-to)e12569
JournalJournal of Food Biochemistry
Volume0
Issue number0
DOIs
Publication statusPublished - Aug 15 2018

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Cordycepin suppressed lipid accumulation via regulating AMPK activity and mitochondrial fusion in hepatocytes. / Uen, Wu-Ching; Shi, Yeu-Ching; Choong, Chen-Yen; Tai, Cheng-Jeng.

In: Journal of Food Biochemistry, Vol. 0, No. 0, 15.08.2018, p. e12569.

Research output: Contribution to journalArticle

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abstract = "Abstract Compound cordycepin (3?-deoxyadenosine) has been used in cancer treatment, diabetes prevention, and anti-virus, as well as hyperlipidemia downregulation in vivo. However, the association between lipid metabolism and mitochondrial activity in cordycepin-treated hepatocytes is remain unclear. In this study, whether cordycepin affects lipogenesis and fatty beta-oxidation through regulating mitochondrial activity and AMP-activated protein kinase (AMPK) in hepatocytes were investigated. The data showed that cordycepin decreased lipid accumulation via activating AMPK and regulating mitochondrial function in oleic acid (OA)-induced mouse FL83B hepatocytes while the anti-fatty liver effect of cordycepin on regulating lipogenesis and fatty beta-oxidation was abolished by AMPK inhibitor compound C treatment. These results suggested that cordycepin attenuated lipid accumulation through promoting beta-oxidation and may be developed as a functional food/natural medicine for fatty liver suppression. Practical applications Traditional herb, Chinese medicine, and functional food treatments for hyperlipidemia are relatively cheap and locally available. The results of this study suggested that cordycepin (active compound of Cordyceps) may be developed as functional foods for fatty liver treatment via regulating fatty beta-oxidation.",
keywords = "AMP-activated protein kinase, cordycepin, fatty beta-oxidation, lipogenesis, mitochondrial activity",
author = "Wu-Ching Uen and Yeu-Ching Shi and Chen-Yen Choong and Cheng-Jeng Tai",
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T1 - Cordycepin suppressed lipid accumulation via regulating AMPK activity and mitochondrial fusion in hepatocytes

AU - Uen, Wu-Ching

AU - Shi, Yeu-Ching

AU - Choong, Chen-Yen

AU - Tai, Cheng-Jeng

N1 - doi: 10.1111/jfbc.12569

PY - 2018/8/15

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N2 - Abstract Compound cordycepin (3?-deoxyadenosine) has been used in cancer treatment, diabetes prevention, and anti-virus, as well as hyperlipidemia downregulation in vivo. However, the association between lipid metabolism and mitochondrial activity in cordycepin-treated hepatocytes is remain unclear. In this study, whether cordycepin affects lipogenesis and fatty beta-oxidation through regulating mitochondrial activity and AMP-activated protein kinase (AMPK) in hepatocytes were investigated. The data showed that cordycepin decreased lipid accumulation via activating AMPK and regulating mitochondrial function in oleic acid (OA)-induced mouse FL83B hepatocytes while the anti-fatty liver effect of cordycepin on regulating lipogenesis and fatty beta-oxidation was abolished by AMPK inhibitor compound C treatment. These results suggested that cordycepin attenuated lipid accumulation through promoting beta-oxidation and may be developed as a functional food/natural medicine for fatty liver suppression. Practical applications Traditional herb, Chinese medicine, and functional food treatments for hyperlipidemia are relatively cheap and locally available. The results of this study suggested that cordycepin (active compound of Cordyceps) may be developed as functional foods for fatty liver treatment via regulating fatty beta-oxidation.

AB - Abstract Compound cordycepin (3?-deoxyadenosine) has been used in cancer treatment, diabetes prevention, and anti-virus, as well as hyperlipidemia downregulation in vivo. However, the association between lipid metabolism and mitochondrial activity in cordycepin-treated hepatocytes is remain unclear. In this study, whether cordycepin affects lipogenesis and fatty beta-oxidation through regulating mitochondrial activity and AMP-activated protein kinase (AMPK) in hepatocytes were investigated. The data showed that cordycepin decreased lipid accumulation via activating AMPK and regulating mitochondrial function in oleic acid (OA)-induced mouse FL83B hepatocytes while the anti-fatty liver effect of cordycepin on regulating lipogenesis and fatty beta-oxidation was abolished by AMPK inhibitor compound C treatment. These results suggested that cordycepin attenuated lipid accumulation through promoting beta-oxidation and may be developed as a functional food/natural medicine for fatty liver suppression. Practical applications Traditional herb, Chinese medicine, and functional food treatments for hyperlipidemia are relatively cheap and locally available. The results of this study suggested that cordycepin (active compound of Cordyceps) may be developed as functional foods for fatty liver treatment via regulating fatty beta-oxidation.

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KW - cordycepin

KW - fatty beta-oxidation

KW - lipogenesis

KW - mitochondrial activity

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