Controllable permeability of blood-brain barrier and reduced brain injury through low-intensity pulsed ultrasound stimulation

Wei Shen Su, Min Lan Tsai, Sin Luo Huang, Shing Hwa Liu, Feng Yi Yang

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

It has been shown that the blood-brain barrier (BBB) can be locally disrupted by focused ultrasound (FUS) in the presence of microbubbles (MB) while sustaining little damage to the brain tissue. Thus, the safety issue associated with FUS-induced BBB disruption (BBBD) needs to be investigated for future clinical applications. This study demonstrated the neuroprotective effects induced by low-intensity pulsed ultrasound (LIPUS) against brain injury in the sonicated brain. Rats subjected to a BBB disruption injury received LIPUS exposure for 5 min after FUS/MB application. Measurements of BBB permeability, brain water content, and histological analysis were then carried out to evaluate the effects of LIPUS. The permeability and time window of FUS-induced BBBD can be effectively modulated with LIPUS. LIPUS also significantly reduced brain edema, neuronal death, and apoptosis in the sonicated brain. Our results show that brain injury in the FUS-induced BBBD model could be ameliorated by LIPUS and that LIPUS may be proposed as a novel treatment modality for controllable release of drugs into the brain.

Original languageEnglish
Pages (from-to)42290-42299
Number of pages10
JournalOncotarget
Volume6
Issue number39
DOIs
Publication statusPublished - Jan 1 2015
Externally publishedYes

Fingerprint

Blood-Brain Barrier
Brain Injuries
Permeability
Brain
Microbubbles
Brain Edema
Neuroprotective Agents
Ultrasonic Waves
Apoptosis
Safety
Water
Wounds and Injuries

Keywords

  • Blood-brain barrier
  • Brain injury
  • Edema
  • Low intensity ultrasound
  • Permeability

ASJC Scopus subject areas

  • Oncology

Cite this

Controllable permeability of blood-brain barrier and reduced brain injury through low-intensity pulsed ultrasound stimulation. / Su, Wei Shen; Tsai, Min Lan; Huang, Sin Luo; Liu, Shing Hwa; Yang, Feng Yi.

In: Oncotarget, Vol. 6, No. 39, 01.01.2015, p. 42290-42299.

Research output: Contribution to journalArticle

Su, Wei Shen ; Tsai, Min Lan ; Huang, Sin Luo ; Liu, Shing Hwa ; Yang, Feng Yi. / Controllable permeability of blood-brain barrier and reduced brain injury through low-intensity pulsed ultrasound stimulation. In: Oncotarget. 2015 ; Vol. 6, No. 39. pp. 42290-42299.
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