Contributions of thyroid hormone to cancer metastasis

Shaker A. Mousa, Gennadi V. Glinsky, Hung Yun Lin, Osnat Ashur-Fabian, Aleck Hercbergs, Kelly A. Keating, Paul J. Davis

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Acting at a cell surface receptor on the extracellular domain of integrin αvβ3, thyroid hormone analogues regulate downstream the expression of a large panel of genes relevant to cancer cell proliferation, to cancer cell survival pathways, and to tumor-linked angiogenesis. Because αvβ is involved in the cancer cell metastatic process, we examine here the possibility that thyroid hormone as L-thyroxine (T4) and the thyroid hormone antagonist, tetraiodothyroacetic acid (tetrac), may respectively promote and inhibit metastasis. Actions of T4 and tetrac that are relevant to cancer metastasis include the multitude of synergistic effects on molecular levels such as expression of matrix metalloproteinase genes, angiogenesis support genes, receptor tyrosine kinase (EGFR/ERBB2) genes, specific microRNAs, the epithelial-mesenchymal transition (EMT) process; and on the cellular level are exemplified by effects on macrophages. We conclude that the thyroid hormone-αvβ interaction is mechanistically linked to cancer metastasis and that modified tetrac molecules have antimetastatic activity with feasible therapeutic potential.

Original languageEnglish
Article number89
JournalBiomedicines
Volume6
Issue number3
DOIs
Publication statusPublished - Sep 1 2018

Fingerprint

Thyroid Hormones
Genes
Neoplasm Metastasis
Thyroxine
Neoplasms
Cells
Hormone Antagonists
Macrophages
Cell proliferation
Receptor Protein-Tyrosine Kinases
Cell Surface Receptors
Matrix Metalloproteinases
MicroRNAs
Integrins
erbB-1 Genes
Tumors
Antithyroid Agents
Epithelial-Mesenchymal Transition
Molecules
Cell Survival

Keywords

  • Angiogenesis
  • Cancer
  • Cancer cell genes
  • Epithelial-to-mesenchymal transition (EMT)
  • Integrin αvβ3
  • L-thyroxine
  • Matrix metalloproteinases
  • Metastasis
  • T4
  • Tetrac
  • Thyroid hormone

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Mousa, S. A., Glinsky, G. V., Lin, H. Y., Ashur-Fabian, O., Hercbergs, A., Keating, K. A., & Davis, P. J. (2018). Contributions of thyroid hormone to cancer metastasis. Biomedicines, 6(3), [89]. https://doi.org/10.3390/biomedicines6030089

Contributions of thyroid hormone to cancer metastasis. / Mousa, Shaker A.; Glinsky, Gennadi V.; Lin, Hung Yun; Ashur-Fabian, Osnat; Hercbergs, Aleck; Keating, Kelly A.; Davis, Paul J.

In: Biomedicines, Vol. 6, No. 3, 89, 01.09.2018.

Research output: Contribution to journalReview article

Mousa, SA, Glinsky, GV, Lin, HY, Ashur-Fabian, O, Hercbergs, A, Keating, KA & Davis, PJ 2018, 'Contributions of thyroid hormone to cancer metastasis', Biomedicines, vol. 6, no. 3, 89. https://doi.org/10.3390/biomedicines6030089
Mousa SA, Glinsky GV, Lin HY, Ashur-Fabian O, Hercbergs A, Keating KA et al. Contributions of thyroid hormone to cancer metastasis. Biomedicines. 2018 Sep 1;6(3). 89. https://doi.org/10.3390/biomedicines6030089
Mousa, Shaker A. ; Glinsky, Gennadi V. ; Lin, Hung Yun ; Ashur-Fabian, Osnat ; Hercbergs, Aleck ; Keating, Kelly A. ; Davis, Paul J. / Contributions of thyroid hormone to cancer metastasis. In: Biomedicines. 2018 ; Vol. 6, No. 3.
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