Contribution of Matrix Metalloproteinase-9 rs3918242 Genotypes to Childhood Leukemia Risk

Chien Chung Kuo, Chia Wen Tsai, Wen Shin Chang, Te Chun Shen, Huey En Tzeng, Chia Hsiang Li, Yun Chi Wang, Fuu Jen Tsai, DA Tian Bau

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1 Citation (Scopus)


BACKGROUND/AIM: A single study has shown positive association and genotype-phenotype correlation between metalloproteinase-9 (MMP-9) promoter genotypes and adult acute lymphocytic leukemia (ALL). However, there is no report about childhood ALL. Thus, this study aimed at examining the role of MMP-9 rs3918242 genotypes in childhood ALL risk. PATIENTS AND METHODS: A total of 266 childhood ALL cases and 266 healthy controls in Taiwan were examined for their MMP-9 rs3918242 genotypes via polymerase chain reaction-restriction fragment length polymorphism methodology. RESULTS: The MMP-9 rs3918242 CT or TT genotype carriers only had a slightly increased risk compared with CC carriers (p=0.6386 and 0.6005, respectively). The allelic frequency analysis also supported the idea that the variant T allele at MMP-9 rs3918242 is not differentially distributed between the case and control groups (p=0.4834). CONCLUSION: MMP-9 rs3918242 genotypes may indirectly influence the risk of childhood ALL. Further validations in other populations and analysis of the detail mechanisms are needed.

Original languageEnglish
Pages (from-to)5751-5756
Number of pages6
JournalAnticancer Research
Issue number10
Publication statusPublished - Oct 1 2020


  • Acute lymphocytic leukemia
  • case–control study
  • childhood
  • genotype
  • MMP-9
  • polymorphism
  • Taiwan

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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