Contribution of genetic polymorphisms of stromal cell-derived factor-1 and its receptor, CXCR4, to the susceptibility and clinicopathologic development of oral cancer

Ying Hock Teng, Te Hsiung Liu, Hsien Chun Tseng, Tsung Te Chung, Chia Ming Yeh, Yu Chiung Li, Yu Hsiang Ou, Long Yau Lin, Hsiu Ting Tsai, Shun Fa Yang

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Background. The aim of this study was to evaluate the relations of SDF-1 and its receptor, CXCR4, gene variants on oral cancer risk. Methods. PCR-RFLP was used to measure SDF-1-3′A and CXCR4 gene polymorphisms in 284 controls and 113 patients with oral cancer. Results. After being adjusted for age, individuals with A/G heterozygotes of SDF-1 had a higher risk of 1.86-fold to develop oral cancer when compared with those with G/G wild type homozygotes. Furthermore, patients with oral cancer with at least 1 mutant T allele of CXCR4 gene had a risk of 2.66-fold to progress to stage III or IV. Conclusions. SDF-1-3′A gene polymorphism may be considered as a factor of increased susceptibility to oral cancer, and at least 1 mutated T allele of CXCR4 gene is associated with the development of stage III or IV and the induction of lymph-node metastasis of oral cancer disease in Taiwanese.

Original languageEnglish
Pages (from-to)1282-1288
Number of pages7
JournalHead and Neck
Volume31
Issue number10
DOIs
Publication statusPublished - Oct 2009
Externally publishedYes

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CXCR4 Receptors
Chemokine CXCL12
Mouth Neoplasms
Genetic Polymorphisms
Genes
Mouth Diseases
Alleles
Homozygote
Heterozygote
Restriction Fragment Length Polymorphisms
Lymph Nodes
Neoplasm Metastasis
Polymerase Chain Reaction

Keywords

  • CXCR4
  • Oral cancer
  • Polymorphism
  • SDF-1

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Contribution of genetic polymorphisms of stromal cell-derived factor-1 and its receptor, CXCR4, to the susceptibility and clinicopathologic development of oral cancer. / Teng, Ying Hock; Liu, Te Hsiung; Tseng, Hsien Chun; Chung, Tsung Te; Yeh, Chia Ming; Li, Yu Chiung; Ou, Yu Hsiang; Lin, Long Yau; Tsai, Hsiu Ting; Yang, Shun Fa.

In: Head and Neck, Vol. 31, No. 10, 10.2009, p. 1282-1288.

Research output: Contribution to journalArticle

Teng, Ying Hock ; Liu, Te Hsiung ; Tseng, Hsien Chun ; Chung, Tsung Te ; Yeh, Chia Ming ; Li, Yu Chiung ; Ou, Yu Hsiang ; Lin, Long Yau ; Tsai, Hsiu Ting ; Yang, Shun Fa. / Contribution of genetic polymorphisms of stromal cell-derived factor-1 and its receptor, CXCR4, to the susceptibility and clinicopathologic development of oral cancer. In: Head and Neck. 2009 ; Vol. 31, No. 10. pp. 1282-1288.
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abstract = "Background. The aim of this study was to evaluate the relations of SDF-1 and its receptor, CXCR4, gene variants on oral cancer risk. Methods. PCR-RFLP was used to measure SDF-1-3′A and CXCR4 gene polymorphisms in 284 controls and 113 patients with oral cancer. Results. After being adjusted for age, individuals with A/G heterozygotes of SDF-1 had a higher risk of 1.86-fold to develop oral cancer when compared with those with G/G wild type homozygotes. Furthermore, patients with oral cancer with at least 1 mutant T allele of CXCR4 gene had a risk of 2.66-fold to progress to stage III or IV. Conclusions. SDF-1-3′A gene polymorphism may be considered as a factor of increased susceptibility to oral cancer, and at least 1 mutated T allele of CXCR4 gene is associated with the development of stage III or IV and the induction of lymph-node metastasis of oral cancer disease in Taiwanese.",
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AU - Tseng, Hsien Chun

AU - Chung, Tsung Te

AU - Yeh, Chia Ming

AU - Li, Yu Chiung

AU - Ou, Yu Hsiang

AU - Lin, Long Yau

AU - Tsai, Hsiu Ting

AU - Yang, Shun Fa

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N2 - Background. The aim of this study was to evaluate the relations of SDF-1 and its receptor, CXCR4, gene variants on oral cancer risk. Methods. PCR-RFLP was used to measure SDF-1-3′A and CXCR4 gene polymorphisms in 284 controls and 113 patients with oral cancer. Results. After being adjusted for age, individuals with A/G heterozygotes of SDF-1 had a higher risk of 1.86-fold to develop oral cancer when compared with those with G/G wild type homozygotes. Furthermore, patients with oral cancer with at least 1 mutant T allele of CXCR4 gene had a risk of 2.66-fold to progress to stage III or IV. Conclusions. SDF-1-3′A gene polymorphism may be considered as a factor of increased susceptibility to oral cancer, and at least 1 mutated T allele of CXCR4 gene is associated with the development of stage III or IV and the induction of lymph-node metastasis of oral cancer disease in Taiwanese.

AB - Background. The aim of this study was to evaluate the relations of SDF-1 and its receptor, CXCR4, gene variants on oral cancer risk. Methods. PCR-RFLP was used to measure SDF-1-3′A and CXCR4 gene polymorphisms in 284 controls and 113 patients with oral cancer. Results. After being adjusted for age, individuals with A/G heterozygotes of SDF-1 had a higher risk of 1.86-fold to develop oral cancer when compared with those with G/G wild type homozygotes. Furthermore, patients with oral cancer with at least 1 mutant T allele of CXCR4 gene had a risk of 2.66-fold to progress to stage III or IV. Conclusions. SDF-1-3′A gene polymorphism may be considered as a factor of increased susceptibility to oral cancer, and at least 1 mutated T allele of CXCR4 gene is associated with the development of stage III or IV and the induction of lymph-node metastasis of oral cancer disease in Taiwanese.

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