Contribution of genetic polymorphisms of stromal cell-derived factor-1 and its receptor, CXCR4, to the susceptibility and clinicopathologic development of oral cancer

Ying Hock Teng, Te Hsiung Liu, Hsien Chun Tseng, Tsung Te Chung, Chia Ming Yeh, Yu Chiung Li, Yu Hsiang Ou, Long Yau Lin, Hsiu Ting Tsai, Shun Fa Yang

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

Background. The aim of this study was to evaluate the relations of SDF-1 and its receptor, CXCR4, gene variants on oral cancer risk. Methods. PCR-RFLP was used to measure SDF-1-3′A and CXCR4 gene polymorphisms in 284 controls and 113 patients with oral cancer. Results. After being adjusted for age, individuals with A/G heterozygotes of SDF-1 had a higher risk of 1.86-fold to develop oral cancer when compared with those with G/G wild type homozygotes. Furthermore, patients with oral cancer with at least 1 mutant T allele of CXCR4 gene had a risk of 2.66-fold to progress to stage III or IV. Conclusions. SDF-1-3′A gene polymorphism may be considered as a factor of increased susceptibility to oral cancer, and at least 1 mutated T allele of CXCR4 gene is associated with the development of stage III or IV and the induction of lymph-node metastasis of oral cancer disease in Taiwanese.

Original languageEnglish
Pages (from-to)1282-1288
Number of pages7
JournalHead and Neck
Volume31
Issue number10
DOIs
Publication statusPublished - Oct 2009
Externally publishedYes

Keywords

  • CXCR4
  • Oral cancer
  • Polymorphism
  • SDF-1

ASJC Scopus subject areas

  • Otorhinolaryngology

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