Abstract

Background & Aims: Contrast-enhanced ultrasound (CEUS) and contrast-enhanced computed tomography (CECT) are used to assess the response of hepatocellular carcinoma after transarterial chemoembolization. Our aim was to perform a systematic review to compare CEUS and CECT for therapeutic response assessment to transarterial chemoembolization in the treatment of hepatocellular carcinoma. Method: PubMed, Embase, and the Cochrane Library databases were searched from inception until January 1, 2016. Participants: patients with hepatocellular carcinoma. Intervention: transarterial chemoembolization and CECT vs CEUS. Results. Sixteen studies were included in the systematic review. The total number of patients was 858 and the mean patient age ranged from 42 to 73 years. The mean tumor size ranged from 1.0 cm to 4.3 cm. The sensitivity and specificity of CEUS ranged from 46% to 100% and 65% to 100%, respectively, and that of CECT ranged from 34% to 87% and 92% to 100%, respectively. The accuracy of CEUS ranged from 72.6% to 100% and that of CECT from 61% to 94%. Marked heterogeneity was present among the studies. Conclusion: CEUS is comparable with CECT for the therapeutic response assessment after transarterial chemoembolization.

Original languageEnglish
Pages (from-to)499-507
Number of pages9
JournalJournal of Gastrointestinal and Liver Diseases
Volume25
Issue number4
DOIs
Publication statusPublished - Dec 1 2016

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Hepatocellular Carcinoma
Tomography
PubMed
Libraries
Therapeutics
Databases
Sensitivity and Specificity
Neoplasms

Keywords

  • Hepatocellular carcinoma – transarterial chemoembolization – contrast-enhanced ultrasound – contrast enhanced CT

ASJC Scopus subject areas

  • Gastroenterology

Cite this

@article{fc3472fb6bc44ba5aed9991b3dd9e9d1,
title = "Contrast-enhanced ultrasound and computed tomography assessment of hepatocellular carcinoma after transcatheter arterial chemo-embolization: A systematic review",
abstract = "Background & Aims: Contrast-enhanced ultrasound (CEUS) and contrast-enhanced computed tomography (CECT) are used to assess the response of hepatocellular carcinoma after transarterial chemoembolization. Our aim was to perform a systematic review to compare CEUS and CECT for therapeutic response assessment to transarterial chemoembolization in the treatment of hepatocellular carcinoma. Method: PubMed, Embase, and the Cochrane Library databases were searched from inception until January 1, 2016. Participants: patients with hepatocellular carcinoma. Intervention: transarterial chemoembolization and CECT vs CEUS. Results. Sixteen studies were included in the systematic review. The total number of patients was 858 and the mean patient age ranged from 42 to 73 years. The mean tumor size ranged from 1.0 cm to 4.3 cm. The sensitivity and specificity of CEUS ranged from 46{\%} to 100{\%} and 65{\%} to 100{\%}, respectively, and that of CECT ranged from 34{\%} to 87{\%} and 92{\%} to 100{\%}, respectively. The accuracy of CEUS ranged from 72.6{\%} to 100{\%} and that of CECT from 61{\%} to 94{\%}. Marked heterogeneity was present among the studies. Conclusion: CEUS is comparable with CECT for the therapeutic response assessment after transarterial chemoembolization.",
keywords = "Hepatocellular carcinoma – transarterial chemoembolization – contrast-enhanced ultrasound – contrast enhanced CT",
author = "Tai, {Cheng Jeng} and Huang, {Ming Te} and Wu, {Chih Hsiung} and Tai, {Chen Jei} and Shi, {Yeu Ching} and Chang, {Chun Chao} and Chang, {Yu Jia} and Kuo, {Li Jen} and Wei, {Po Lei} and Chen, {Ray Jade} and Chiou, {Hung Yi}",
year = "2016",
month = "12",
day = "1",
doi = "10.15403/jgld.2014.1121.254.tai",
language = "English",
volume = "25",
pages = "499--507",
journal = "Journal of Gastrointestinal and Liver Diseases",
issn = "1841-8724",
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}

TY - JOUR

T1 - Contrast-enhanced ultrasound and computed tomography assessment of hepatocellular carcinoma after transcatheter arterial chemo-embolization

T2 - A systematic review

AU - Tai, Cheng Jeng

AU - Huang, Ming Te

AU - Wu, Chih Hsiung

AU - Tai, Chen Jei

AU - Shi, Yeu Ching

AU - Chang, Chun Chao

AU - Chang, Yu Jia

AU - Kuo, Li Jen

AU - Wei, Po Lei

AU - Chen, Ray Jade

AU - Chiou, Hung Yi

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Background & Aims: Contrast-enhanced ultrasound (CEUS) and contrast-enhanced computed tomography (CECT) are used to assess the response of hepatocellular carcinoma after transarterial chemoembolization. Our aim was to perform a systematic review to compare CEUS and CECT for therapeutic response assessment to transarterial chemoembolization in the treatment of hepatocellular carcinoma. Method: PubMed, Embase, and the Cochrane Library databases were searched from inception until January 1, 2016. Participants: patients with hepatocellular carcinoma. Intervention: transarterial chemoembolization and CECT vs CEUS. Results. Sixteen studies were included in the systematic review. The total number of patients was 858 and the mean patient age ranged from 42 to 73 years. The mean tumor size ranged from 1.0 cm to 4.3 cm. The sensitivity and specificity of CEUS ranged from 46% to 100% and 65% to 100%, respectively, and that of CECT ranged from 34% to 87% and 92% to 100%, respectively. The accuracy of CEUS ranged from 72.6% to 100% and that of CECT from 61% to 94%. Marked heterogeneity was present among the studies. Conclusion: CEUS is comparable with CECT for the therapeutic response assessment after transarterial chemoembolization.

AB - Background & Aims: Contrast-enhanced ultrasound (CEUS) and contrast-enhanced computed tomography (CECT) are used to assess the response of hepatocellular carcinoma after transarterial chemoembolization. Our aim was to perform a systematic review to compare CEUS and CECT for therapeutic response assessment to transarterial chemoembolization in the treatment of hepatocellular carcinoma. Method: PubMed, Embase, and the Cochrane Library databases were searched from inception until January 1, 2016. Participants: patients with hepatocellular carcinoma. Intervention: transarterial chemoembolization and CECT vs CEUS. Results. Sixteen studies were included in the systematic review. The total number of patients was 858 and the mean patient age ranged from 42 to 73 years. The mean tumor size ranged from 1.0 cm to 4.3 cm. The sensitivity and specificity of CEUS ranged from 46% to 100% and 65% to 100%, respectively, and that of CECT ranged from 34% to 87% and 92% to 100%, respectively. The accuracy of CEUS ranged from 72.6% to 100% and that of CECT from 61% to 94%. Marked heterogeneity was present among the studies. Conclusion: CEUS is comparable with CECT for the therapeutic response assessment after transarterial chemoembolization.

KW - Hepatocellular carcinoma – transarterial chemoembolization – contrast-enhanced ultrasound – contrast enhanced CT

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