Construct logic operation gates of OR and and with multiple enzymes

Chu Yuyi, Juiyu Wu, Junzo Watada, Ikno Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Biomoleculars act as a tool to build a multiple enzyme system based on human metabolic actions to perform basic logic operation connecting OR and AND gates. Three enzymes (invertase, amyloglucosidase, hexokinase) concert as a logic operation part, processing three molecular input signals (sucrose, maltose, and ATP) to produce G6P (glucose-6-phosphate). The other two enzymes glucose-6-phosphate dehydrogenase (G6PD) and salicylate hydroxylase (SHL) compose to function as a signal displayer. Furthermore, we used a latent fluorescent molecule composed of sacylate and fluorescence which can be catalyzed and release fluorescent molecular to produce output signal. According to our experiments, firstly, our design is proved. The typical characteristics of enzyme reactions have been discovered through comparing the expected theoretical cures with the result cures. Secondly, the possibility of applying multiple logic gates into complicate networks has been shown.

Original languageEnglish
Title of host publicationProceedings - 4th International Conference on Genetic and Evolutionary Computing, ICGEC 2010
Pages35-38
Number of pages4
DOIs
Publication statusPublished - 2010
Event4th International Conference on Genetic and Evolutionary Computing, ICGEC 2010 - Shenzhen, China
Duration: Dec 13 2010Dec 15 2010

Other

Other4th International Conference on Genetic and Evolutionary Computing, ICGEC 2010
CountryChina
CityShenzhen
Period12/13/1012/15/10

Keywords

  • Bio-computing
  • Boolean logic gates
  • Enzymes
  • Latent fluorophore

ASJC Scopus subject areas

  • Computational Theory and Mathematics
  • Theoretical Computer Science

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