Construct logic operation gates of OR and and with multiple enzymes

Chu Yuyi, Juiyu Wu, Junzo Watada, Ikno Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Biomoleculars act as a tool to build a multiple enzyme system based on human metabolic actions to perform basic logic operation connecting OR and AND gates. Three enzymes (invertase, amyloglucosidase, hexokinase) concert as a logic operation part, processing three molecular input signals (sucrose, maltose, and ATP) to produce G6P (glucose-6-phosphate). The other two enzymes glucose-6-phosphate dehydrogenase (G6PD) and salicylate hydroxylase (SHL) compose to function as a signal displayer. Furthermore, we used a latent fluorescent molecule composed of sacylate and fluorescence which can be catalyzed and release fluorescent molecular to produce output signal. According to our experiments, firstly, our design is proved. The typical characteristics of enzyme reactions have been discovered through comparing the expected theoretical cures with the result cures. Secondly, the possibility of applying multiple logic gates into complicate networks has been shown.

Original languageEnglish
Title of host publicationProceedings - 4th International Conference on Genetic and Evolutionary Computing, ICGEC 2010
Pages35-38
Number of pages4
DOIs
Publication statusPublished - 2010
Event4th International Conference on Genetic and Evolutionary Computing, ICGEC 2010 - Shenzhen, China
Duration: Dec 13 2010Dec 15 2010

Other

Other4th International Conference on Genetic and Evolutionary Computing, ICGEC 2010
CountryChina
CityShenzhen
Period12/13/1012/15/10

Fingerprint

Enzymes
Logic
Glucose
Phosphate
Phosphates
Maltose
Logic gates
Adenosinetriphosphate
Sugar (sucrose)
Sucrose
Fluorescence
Display
Display devices
Molecules
Output
Processing
Experiment
Experiments

Keywords

  • Bio-computing
  • Boolean logic gates
  • Enzymes
  • Latent fluorophore

ASJC Scopus subject areas

  • Computational Theory and Mathematics
  • Theoretical Computer Science

Cite this

Yuyi, C., Wu, J., Watada, J., & Kim, I. (2010). Construct logic operation gates of OR and and with multiple enzymes. In Proceedings - 4th International Conference on Genetic and Evolutionary Computing, ICGEC 2010 (pp. 35-38). [5715364] https://doi.org/10.1109/ICGEC.2010.17

Construct logic operation gates of OR and and with multiple enzymes. / Yuyi, Chu; Wu, Juiyu; Watada, Junzo; Kim, Ikno.

Proceedings - 4th International Conference on Genetic and Evolutionary Computing, ICGEC 2010. 2010. p. 35-38 5715364.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Yuyi, C, Wu, J, Watada, J & Kim, I 2010, Construct logic operation gates of OR and and with multiple enzymes. in Proceedings - 4th International Conference on Genetic and Evolutionary Computing, ICGEC 2010., 5715364, pp. 35-38, 4th International Conference on Genetic and Evolutionary Computing, ICGEC 2010, Shenzhen, China, 12/13/10. https://doi.org/10.1109/ICGEC.2010.17
Yuyi C, Wu J, Watada J, Kim I. Construct logic operation gates of OR and and with multiple enzymes. In Proceedings - 4th International Conference on Genetic and Evolutionary Computing, ICGEC 2010. 2010. p. 35-38. 5715364 https://doi.org/10.1109/ICGEC.2010.17
Yuyi, Chu ; Wu, Juiyu ; Watada, Junzo ; Kim, Ikno. / Construct logic operation gates of OR and and with multiple enzymes. Proceedings - 4th International Conference on Genetic and Evolutionary Computing, ICGEC 2010. 2010. pp. 35-38
@inproceedings{6f8d993bc4de4b6db3f274f62b646b54,
title = "Construct logic operation gates of OR and and with multiple enzymes",
abstract = "Biomoleculars act as a tool to build a multiple enzyme system based on human metabolic actions to perform basic logic operation connecting OR and AND gates. Three enzymes (invertase, amyloglucosidase, hexokinase) concert as a logic operation part, processing three molecular input signals (sucrose, maltose, and ATP) to produce G6P (glucose-6-phosphate). The other two enzymes glucose-6-phosphate dehydrogenase (G6PD) and salicylate hydroxylase (SHL) compose to function as a signal displayer. Furthermore, we used a latent fluorescent molecule composed of sacylate and fluorescence which can be catalyzed and release fluorescent molecular to produce output signal. According to our experiments, firstly, our design is proved. The typical characteristics of enzyme reactions have been discovered through comparing the expected theoretical cures with the result cures. Secondly, the possibility of applying multiple logic gates into complicate networks has been shown.",
keywords = "Bio-computing, Boolean logic gates, Enzymes, Latent fluorophore",
author = "Chu Yuyi and Juiyu Wu and Junzo Watada and Ikno Kim",
year = "2010",
doi = "10.1109/ICGEC.2010.17",
language = "English",
isbn = "9780769542812",
pages = "35--38",
booktitle = "Proceedings - 4th International Conference on Genetic and Evolutionary Computing, ICGEC 2010",

}

TY - GEN

T1 - Construct logic operation gates of OR and and with multiple enzymes

AU - Yuyi, Chu

AU - Wu, Juiyu

AU - Watada, Junzo

AU - Kim, Ikno

PY - 2010

Y1 - 2010

N2 - Biomoleculars act as a tool to build a multiple enzyme system based on human metabolic actions to perform basic logic operation connecting OR and AND gates. Three enzymes (invertase, amyloglucosidase, hexokinase) concert as a logic operation part, processing three molecular input signals (sucrose, maltose, and ATP) to produce G6P (glucose-6-phosphate). The other two enzymes glucose-6-phosphate dehydrogenase (G6PD) and salicylate hydroxylase (SHL) compose to function as a signal displayer. Furthermore, we used a latent fluorescent molecule composed of sacylate and fluorescence which can be catalyzed and release fluorescent molecular to produce output signal. According to our experiments, firstly, our design is proved. The typical characteristics of enzyme reactions have been discovered through comparing the expected theoretical cures with the result cures. Secondly, the possibility of applying multiple logic gates into complicate networks has been shown.

AB - Biomoleculars act as a tool to build a multiple enzyme system based on human metabolic actions to perform basic logic operation connecting OR and AND gates. Three enzymes (invertase, amyloglucosidase, hexokinase) concert as a logic operation part, processing three molecular input signals (sucrose, maltose, and ATP) to produce G6P (glucose-6-phosphate). The other two enzymes glucose-6-phosphate dehydrogenase (G6PD) and salicylate hydroxylase (SHL) compose to function as a signal displayer. Furthermore, we used a latent fluorescent molecule composed of sacylate and fluorescence which can be catalyzed and release fluorescent molecular to produce output signal. According to our experiments, firstly, our design is proved. The typical characteristics of enzyme reactions have been discovered through comparing the expected theoretical cures with the result cures. Secondly, the possibility of applying multiple logic gates into complicate networks has been shown.

KW - Bio-computing

KW - Boolean logic gates

KW - Enzymes

KW - Latent fluorophore

UR - http://www.scopus.com/inward/record.url?scp=79952563609&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952563609&partnerID=8YFLogxK

U2 - 10.1109/ICGEC.2010.17

DO - 10.1109/ICGEC.2010.17

M3 - Conference contribution

AN - SCOPUS:79952563609

SN - 9780769542812

SP - 35

EP - 38

BT - Proceedings - 4th International Conference on Genetic and Evolutionary Computing, ICGEC 2010

ER -