Constituents of Polyalthia longifolia var. pendula

Zong-Huei Li, Mei Jhen Wang, Pi Yu Chen, Tung Ying Wu, Wu Che Wen, Fu Yu Tsai, Ching Kuo Lee

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Three new clerodane-type diterpenes, 6R,16-dihydroxycleroda-3,13-dien-15- oic acid (1), 6α,16-dihydroxycleroda-4(18),13-dien-15-oic acid (2), and 4α,18β-epoxy-16-hydroxyclerod-13-en-15-oic acid (3), and four new protoberberine alkaloids, (-)-8-oxo-10-hydroxy-2,3,9-trimethoxyberberine (4), (-)-8-oxo-2,11-dihydroxy-3,10-dimethoxyberberine (5), (-)-8-oxo-11-hydroxy-2,3, 9,10-tetramethoxyberberine (6), and (-)-8-oxo-2,10-dihydroxy-3,9,11- trimethoxyberberine (7), together with 11 known substances, were isolated from a methanol extract of the stems of Polyalthia longifolia var. pendula. The structures of 1-7 were elucidated on the basis of spectroscopic data analysis. Compounds were evaluated for their antiproliferative activities against A549 and MCF-7 cancer cells, and among the substances tested, only 16-oxo-cleroda-3,13- dien-15-oic acid (8) exhibited cytotoxicity.

Original languageEnglish
Pages (from-to)1960-1963
Number of pages4
JournalJournal of Natural Products
Volume72
Issue number11
DOIs
Publication statusPublished - Nov 30 2009

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Polyalthia
Acids
Clerodane Diterpenes
MCF-7 Cells
Cytotoxicity
Alkaloids
Methanol
Cells
Neoplasms

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Li, Z-H., Wang, M. J., Chen, P. Y., Wu, T. Y., Wen, W. C., Tsai, F. Y., & Lee, C. K. (2009). Constituents of Polyalthia longifolia var. pendula. Journal of Natural Products, 72(11), 1960-1963. https://doi.org/10.1021/np900207z

Constituents of Polyalthia longifolia var. pendula. / Li, Zong-Huei; Wang, Mei Jhen; Chen, Pi Yu; Wu, Tung Ying; Wen, Wu Che; Tsai, Fu Yu; Lee, Ching Kuo.

In: Journal of Natural Products, Vol. 72, No. 11, 30.11.2009, p. 1960-1963.

Research output: Contribution to journalArticle

Li, Z-H, Wang, MJ, Chen, PY, Wu, TY, Wen, WC, Tsai, FY & Lee, CK 2009, 'Constituents of Polyalthia longifolia var. pendula', Journal of Natural Products, vol. 72, no. 11, pp. 1960-1963. https://doi.org/10.1021/np900207z
Li Z-H, Wang MJ, Chen PY, Wu TY, Wen WC, Tsai FY et al. Constituents of Polyalthia longifolia var. pendula. Journal of Natural Products. 2009 Nov 30;72(11):1960-1963. https://doi.org/10.1021/np900207z
Li, Zong-Huei ; Wang, Mei Jhen ; Chen, Pi Yu ; Wu, Tung Ying ; Wen, Wu Che ; Tsai, Fu Yu ; Lee, Ching Kuo. / Constituents of Polyalthia longifolia var. pendula. In: Journal of Natural Products. 2009 ; Vol. 72, No. 11. pp. 1960-1963.
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