Consensus on the clinical management, screening-to-treat, and surveillance of Helicobacter pylori infection to improve gastric cancer control on a nationwide scale

Bor Shyang Sheu, Ming Shiang Wu, Cheng Tang Chiu, Jing Chuan Lo, Deng Chyang Wu, Jyh Ming Liou, Chun Ying Wu, Hsiu Chi Cheng, Yi Chia Lee, Ping I. Hsu, Chun Chao Chang, Wei Lun Chang, Jaw Town Lin

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Previous international consensus statements provided general policies for the management of Helicobacter pylori infection. However, there are geographic differences in the prevalence and antimicrobial resistance of H. pylori, and in the availability of medications and endoscopy. Thus, nationwide or regional consensus statements are needed to improve control of H. pylori infection and gastric cancer. Materials and Methods: This consensus statement for management of H. pylori in Taiwan has three major sections: (1) optimal diagnosis and indications; (2) current treatment strategies; and (3) screening-to-treat and surveillance for control of gastric cancer. The literature review emphasized recent data for development of draft statements and determination of levels of evidence. Twenty-five Taiwan experts conducted a consensus conference, by a modified Delphi process, to modify the draft statements. Consensus, defined as an agreement of least 80% of the experts, and recommendation grade were determined by anonymous voting. Results: There were 24 consensus statements. Section 1 has seven statements on recommendations for the diagnosis and indications for treatment of H. pylori infection. Section 2 has 10 statements that provide an updated treatment algorithm for first-line, second-line, and third-line regimens. Section 3 has seven statements regarding H. pylori eradication for reducing the risk of gastric cancer, with a cost-benefit analysis. After H. pylori eradication, the consensus highlights the use of endoscopic surveillance and/or chemoprevention to further reduce the burden of gastric cancer. Conclusions: This consensus statement has updated recommendations for improving the clinical management of H. pylori infection in areas such as Taiwan, which have high prevalence of H. pylori infection and gastric cancer.

Original languageEnglish
JournalHelicobacter
DOIs
Publication statusAccepted/In press - 2017

Fingerprint

Helicobacter Infections
Helicobacter pylori
Stomach Neoplasms
Taiwan
Chemoprevention
Politics
Endoscopy
Cost-Benefit Analysis
Therapeutics

Keywords

  • Helicobacter pylori
  • Consensus
  • Endoscopy
  • Eradication
  • Gastric cancer
  • Gastric precancerous lesion
  • Level of evidence
  • Peptic ulcer
  • Proton-pump inhibitor

ASJC Scopus subject areas

  • Gastroenterology
  • Infectious Diseases

Cite this

Consensus on the clinical management, screening-to-treat, and surveillance of Helicobacter pylori infection to improve gastric cancer control on a nationwide scale. / Sheu, Bor Shyang; Wu, Ming Shiang; Chiu, Cheng Tang; Lo, Jing Chuan; Wu, Deng Chyang; Liou, Jyh Ming; Wu, Chun Ying; Cheng, Hsiu Chi; Lee, Yi Chia; Hsu, Ping I.; Chang, Chun Chao; Chang, Wei Lun; Lin, Jaw Town.

In: Helicobacter, 2017.

Research output: Contribution to journalArticle

Sheu, Bor Shyang ; Wu, Ming Shiang ; Chiu, Cheng Tang ; Lo, Jing Chuan ; Wu, Deng Chyang ; Liou, Jyh Ming ; Wu, Chun Ying ; Cheng, Hsiu Chi ; Lee, Yi Chia ; Hsu, Ping I. ; Chang, Chun Chao ; Chang, Wei Lun ; Lin, Jaw Town. / Consensus on the clinical management, screening-to-treat, and surveillance of Helicobacter pylori infection to improve gastric cancer control on a nationwide scale. In: Helicobacter. 2017.
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abstract = "Background: Previous international consensus statements provided general policies for the management of Helicobacter pylori infection. However, there are geographic differences in the prevalence and antimicrobial resistance of H. pylori, and in the availability of medications and endoscopy. Thus, nationwide or regional consensus statements are needed to improve control of H. pylori infection and gastric cancer. Materials and Methods: This consensus statement for management of H. pylori in Taiwan has three major sections: (1) optimal diagnosis and indications; (2) current treatment strategies; and (3) screening-to-treat and surveillance for control of gastric cancer. The literature review emphasized recent data for development of draft statements and determination of levels of evidence. Twenty-five Taiwan experts conducted a consensus conference, by a modified Delphi process, to modify the draft statements. Consensus, defined as an agreement of least 80{\%} of the experts, and recommendation grade were determined by anonymous voting. Results: There were 24 consensus statements. Section 1 has seven statements on recommendations for the diagnosis and indications for treatment of H. pylori infection. Section 2 has 10 statements that provide an updated treatment algorithm for first-line, second-line, and third-line regimens. Section 3 has seven statements regarding H. pylori eradication for reducing the risk of gastric cancer, with a cost-benefit analysis. After H. pylori eradication, the consensus highlights the use of endoscopic surveillance and/or chemoprevention to further reduce the burden of gastric cancer. Conclusions: This consensus statement has updated recommendations for improving the clinical management of H. pylori infection in areas such as Taiwan, which have high prevalence of H. pylori infection and gastric cancer.",
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T1 - Consensus on the clinical management, screening-to-treat, and surveillance of Helicobacter pylori infection to improve gastric cancer control on a nationwide scale

AU - Sheu, Bor Shyang

AU - Wu, Ming Shiang

AU - Chiu, Cheng Tang

AU - Lo, Jing Chuan

AU - Wu, Deng Chyang

AU - Liou, Jyh Ming

AU - Wu, Chun Ying

AU - Cheng, Hsiu Chi

AU - Lee, Yi Chia

AU - Hsu, Ping I.

AU - Chang, Chun Chao

AU - Chang, Wei Lun

AU - Lin, Jaw Town

PY - 2017

Y1 - 2017

N2 - Background: Previous international consensus statements provided general policies for the management of Helicobacter pylori infection. However, there are geographic differences in the prevalence and antimicrobial resistance of H. pylori, and in the availability of medications and endoscopy. Thus, nationwide or regional consensus statements are needed to improve control of H. pylori infection and gastric cancer. Materials and Methods: This consensus statement for management of H. pylori in Taiwan has three major sections: (1) optimal diagnosis and indications; (2) current treatment strategies; and (3) screening-to-treat and surveillance for control of gastric cancer. The literature review emphasized recent data for development of draft statements and determination of levels of evidence. Twenty-five Taiwan experts conducted a consensus conference, by a modified Delphi process, to modify the draft statements. Consensus, defined as an agreement of least 80% of the experts, and recommendation grade were determined by anonymous voting. Results: There were 24 consensus statements. Section 1 has seven statements on recommendations for the diagnosis and indications for treatment of H. pylori infection. Section 2 has 10 statements that provide an updated treatment algorithm for first-line, second-line, and third-line regimens. Section 3 has seven statements regarding H. pylori eradication for reducing the risk of gastric cancer, with a cost-benefit analysis. After H. pylori eradication, the consensus highlights the use of endoscopic surveillance and/or chemoprevention to further reduce the burden of gastric cancer. Conclusions: This consensus statement has updated recommendations for improving the clinical management of H. pylori infection in areas such as Taiwan, which have high prevalence of H. pylori infection and gastric cancer.

AB - Background: Previous international consensus statements provided general policies for the management of Helicobacter pylori infection. However, there are geographic differences in the prevalence and antimicrobial resistance of H. pylori, and in the availability of medications and endoscopy. Thus, nationwide or regional consensus statements are needed to improve control of H. pylori infection and gastric cancer. Materials and Methods: This consensus statement for management of H. pylori in Taiwan has three major sections: (1) optimal diagnosis and indications; (2) current treatment strategies; and (3) screening-to-treat and surveillance for control of gastric cancer. The literature review emphasized recent data for development of draft statements and determination of levels of evidence. Twenty-five Taiwan experts conducted a consensus conference, by a modified Delphi process, to modify the draft statements. Consensus, defined as an agreement of least 80% of the experts, and recommendation grade were determined by anonymous voting. Results: There were 24 consensus statements. Section 1 has seven statements on recommendations for the diagnosis and indications for treatment of H. pylori infection. Section 2 has 10 statements that provide an updated treatment algorithm for first-line, second-line, and third-line regimens. Section 3 has seven statements regarding H. pylori eradication for reducing the risk of gastric cancer, with a cost-benefit analysis. After H. pylori eradication, the consensus highlights the use of endoscopic surveillance and/or chemoprevention to further reduce the burden of gastric cancer. Conclusions: This consensus statement has updated recommendations for improving the clinical management of H. pylori infection in areas such as Taiwan, which have high prevalence of H. pylori infection and gastric cancer.

KW - Helicobacter pylori

KW - Consensus

KW - Endoscopy

KW - Eradication

KW - Gastric cancer

KW - Gastric precancerous lesion

KW - Level of evidence

KW - Peptic ulcer

KW - Proton-pump inhibitor

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U2 - 10.1111/hel.12368

DO - 10.1111/hel.12368

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JO - Helicobacter

JF - Helicobacter

SN - 1083-4389

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