Conn's Syndrome with an Unusual Presentation of Rhabdomyolysis Secondary to Severe Hypokalemia

Tien Hua Chuang, Chih Hsein Wang, Bo Yuan Tseng, Yung Hsiang Hsu, Jen Pi Tsai, Bang Gee Hsu, Te Chao Fang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Conn's syndrome is one of the major causes of secondary hypertension. Premature hypertension, metabolic alkalosis, and hypokalemia usually lead clinicians to suspect the diagnosis. We describe a case of Conn's syndrome in a 28-year-old woman with an unusual presentation of rhabdomyolysis secondary to hypokalemia and complete bilateral lower limb paralysis. An elevated transtubular potassium concentration gradient, asymptomatic severe hypertension, and metabolic alkalosis pointed to possible primary hyperaldosteronism, which was confirmed by a decrease in plasma renin activity (PRA), elevation in plasma aldosterone level and elevation of the plasma aldosterone to PRA ratio. Computed tomography showed an adrenal tumor in the adrenal gland. Her blood pressure, hypokalemia, and plasma aldosterone level returned to normal after left adrenalectomy, further confirming the diagnosis. Histologic examination showed an adrenal gland adenoma.

Original languageEnglish
Pages (from-to)327-331
Number of pages5
JournalTzu Chi Medical Journal
Volume20
Issue number4
DOIs
Publication statusPublished - Dec 2008
Externally publishedYes

Fingerprint

Hyperaldosteronism
Rhabdomyolysis
Hypokalemia
Aldosterone
Alkalosis
Adrenal Glands
Hypertension
Renin
Glandular and Epithelial Neoplasms
Paraplegia
Adrenalectomy
Adenoma
Potassium
Tomography
Blood Pressure

Keywords

  • Conn's syndrome
  • Hypokalemia
  • Rhabdomyolysis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Conn's Syndrome with an Unusual Presentation of Rhabdomyolysis Secondary to Severe Hypokalemia. / Chuang, Tien Hua; Wang, Chih Hsein; Tseng, Bo Yuan; Hsu, Yung Hsiang; Tsai, Jen Pi; Hsu, Bang Gee; Fang, Te Chao.

In: Tzu Chi Medical Journal, Vol. 20, No. 4, 12.2008, p. 327-331.

Research output: Contribution to journalArticle

Chuang, Tien Hua ; Wang, Chih Hsein ; Tseng, Bo Yuan ; Hsu, Yung Hsiang ; Tsai, Jen Pi ; Hsu, Bang Gee ; Fang, Te Chao. / Conn's Syndrome with an Unusual Presentation of Rhabdomyolysis Secondary to Severe Hypokalemia. In: Tzu Chi Medical Journal. 2008 ; Vol. 20, No. 4. pp. 327-331.
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AU - Tsai, Jen Pi

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