Concurrent improvement in biocompatibility and bioinertness of diamond-like carbon films with nitrogen doping

Wen Hsiang Liao, Chii Ruey Lin, Da Hua Wei, You Ruey Shen, Yi Chieh Li, Jen Ai Lee, Chia Yao Liang

Research output: Contribution to journalArticle

17 Citations (Scopus)


The surfaces of implantable biomaterials improving biocompatibility and bioinertness are critical for new application of bioimplantable devices. Diamond-like carbon (DLC) film is a promising biomaterial with use for coating bioimplantable devices because of its good biocompatibility, bioinertness, and mechanical properties. In this study, concurrent improvement in biocompatibility and bioinertness of DLC films has been achieved using N-incorporation technique. The N doping degree was found to play an important role in affecting the biocompatibility and bioinertness of N-doped DLC films. The results indicated that the N-doped DLC films deposited at N2 concentration of 5% could help to create suitable condition of surface/structure/adhesion combination of DLC films in the both affinity of the L929 mouse fibroblasts and electrochemical inertness in the Hank's balanced salt solutions (simulating human body fluids). N doping supports the attachment and proliferation of cells and prevents the permeation of electrolyte solutions, thereby simultaneity improved the biocompatibility and bioinertness of DLC films. This finding is useful for the fabrication and encapsulation of in vivo devices without induced immune response in the human body.

Original languageEnglish
Pages (from-to)3151-3156
Number of pages6
JournalJournal of Biomedical Materials Research - Part A
Volume100 A
Issue number11
Publication statusPublished - Nov 2012



  • Adhesion
  • Biocompatibility
  • Bioinertness
  • Cell proliferation
  • Implantable biomaterials
  • N-doped diamond-like carbon

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Ceramics and Composites
  • Metals and Alloys

Cite this