Concurrent elicitation of electroencephalographic desynchronization and penile erection by cocaine in the rat

Alice Y.W. Chang, Terry B.J. Kuo, Julie Y.H. Chan, Samuel H.H. Chan

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

It is well-known from animal and human studies that, as a central nervous stimulant, cocaine induces electroencephalographic (EEG) desynchronization. Cocaine also purportedly increases sexual behavior as an aphrodisiac. Whether the effects of cocaine on EEG activity and penile erection are mechanistically linked, however, remains to be fully elucidated. We evaluated whether this link exists, based on simultaneous recording of EEG signals from the somatosensory cortex and intracavernous pressure (ICP, as experimental index for penile erection) in adult, male Sprague-Dawley rats. Under intraperitoneal chloral hydrate anesthesia (400 mg/kg, i.p.), both intravenous (i.v.) and intracavernous (i.c.) administration of cocaine (1.5 or 3.0 mg/kg, and 75 or 150 μg) dose-dependently induced discernible EEG desynchronization, as represented by a decrease in root mean square and an increase in mean power frequency values, and an increase in ICP. However, the same administration of cocaine in animals under pentobarbital sodium anesthesia (50 mg/kg, i.p.) failed to significantly affect EEG activity, despite an appreciable dose-dependent elevation in ICP. On the other hand, intracerebroventricular administration of cocaine (7.5, 15, or 30 μg) induced significant EEG activation without affecting ICP. I.c. application of papaverine (400 μg) elicited a discernible increase in ICP, but failed to evoke EEG desynchronization. These results suggest that the concurrent EEG desynchronization and penile erection elicited by cocaine may take place without a mutually causative relationship.

Original languageEnglish
Pages (from-to)233-239
Number of pages7
JournalSynapse
Volume24
Issue number3
DOIs
Publication statusPublished - Nov 1996
Externally publishedYes

Fingerprint

Penile Erection
Cocaine
Anesthesia
Aphrodisiacs
Central Nervous System Stimulants
Chloral Hydrate
Papaverine
Somatosensory Cortex
Pentobarbital
Sexual Behavior
Intravenous Administration
Sprague Dawley Rats
Pressure

Keywords

  • Intracavernous pressure
  • Mean power frequency
  • Power spectral analysis
  • Root mean square

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Concurrent elicitation of electroencephalographic desynchronization and penile erection by cocaine in the rat. / Chang, Alice Y.W.; Kuo, Terry B.J.; Chan, Julie Y.H.; Chan, Samuel H.H.

In: Synapse, Vol. 24, No. 3, 11.1996, p. 233-239.

Research output: Contribution to journalArticle

Chang, Alice Y.W. ; Kuo, Terry B.J. ; Chan, Julie Y.H. ; Chan, Samuel H.H. / Concurrent elicitation of electroencephalographic desynchronization and penile erection by cocaine in the rat. In: Synapse. 1996 ; Vol. 24, No. 3. pp. 233-239.
@article{c1afb91a2ad04e5fbbfee3c80ce8abb8,
title = "Concurrent elicitation of electroencephalographic desynchronization and penile erection by cocaine in the rat",
abstract = "It is well-known from animal and human studies that, as a central nervous stimulant, cocaine induces electroencephalographic (EEG) desynchronization. Cocaine also purportedly increases sexual behavior as an aphrodisiac. Whether the effects of cocaine on EEG activity and penile erection are mechanistically linked, however, remains to be fully elucidated. We evaluated whether this link exists, based on simultaneous recording of EEG signals from the somatosensory cortex and intracavernous pressure (ICP, as experimental index for penile erection) in adult, male Sprague-Dawley rats. Under intraperitoneal chloral hydrate anesthesia (400 mg/kg, i.p.), both intravenous (i.v.) and intracavernous (i.c.) administration of cocaine (1.5 or 3.0 mg/kg, and 75 or 150 μg) dose-dependently induced discernible EEG desynchronization, as represented by a decrease in root mean square and an increase in mean power frequency values, and an increase in ICP. However, the same administration of cocaine in animals under pentobarbital sodium anesthesia (50 mg/kg, i.p.) failed to significantly affect EEG activity, despite an appreciable dose-dependent elevation in ICP. On the other hand, intracerebroventricular administration of cocaine (7.5, 15, or 30 μg) induced significant EEG activation without affecting ICP. I.c. application of papaverine (400 μg) elicited a discernible increase in ICP, but failed to evoke EEG desynchronization. These results suggest that the concurrent EEG desynchronization and penile erection elicited by cocaine may take place without a mutually causative relationship.",
keywords = "Intracavernous pressure, Mean power frequency, Power spectral analysis, Root mean square",
author = "Chang, {Alice Y.W.} and Kuo, {Terry B.J.} and Chan, {Julie Y.H.} and Chan, {Samuel H.H.}",
year = "1996",
month = "11",
doi = "10.1002/(SICI)1098-2396(199611)24:3<233::AID-SYN5>3.0.CO;2-F",
language = "English",
volume = "24",
pages = "233--239",
journal = "Synapse",
issn = "0887-4476",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - Concurrent elicitation of electroencephalographic desynchronization and penile erection by cocaine in the rat

AU - Chang, Alice Y.W.

AU - Kuo, Terry B.J.

AU - Chan, Julie Y.H.

AU - Chan, Samuel H.H.

PY - 1996/11

Y1 - 1996/11

N2 - It is well-known from animal and human studies that, as a central nervous stimulant, cocaine induces electroencephalographic (EEG) desynchronization. Cocaine also purportedly increases sexual behavior as an aphrodisiac. Whether the effects of cocaine on EEG activity and penile erection are mechanistically linked, however, remains to be fully elucidated. We evaluated whether this link exists, based on simultaneous recording of EEG signals from the somatosensory cortex and intracavernous pressure (ICP, as experimental index for penile erection) in adult, male Sprague-Dawley rats. Under intraperitoneal chloral hydrate anesthesia (400 mg/kg, i.p.), both intravenous (i.v.) and intracavernous (i.c.) administration of cocaine (1.5 or 3.0 mg/kg, and 75 or 150 μg) dose-dependently induced discernible EEG desynchronization, as represented by a decrease in root mean square and an increase in mean power frequency values, and an increase in ICP. However, the same administration of cocaine in animals under pentobarbital sodium anesthesia (50 mg/kg, i.p.) failed to significantly affect EEG activity, despite an appreciable dose-dependent elevation in ICP. On the other hand, intracerebroventricular administration of cocaine (7.5, 15, or 30 μg) induced significant EEG activation without affecting ICP. I.c. application of papaverine (400 μg) elicited a discernible increase in ICP, but failed to evoke EEG desynchronization. These results suggest that the concurrent EEG desynchronization and penile erection elicited by cocaine may take place without a mutually causative relationship.

AB - It is well-known from animal and human studies that, as a central nervous stimulant, cocaine induces electroencephalographic (EEG) desynchronization. Cocaine also purportedly increases sexual behavior as an aphrodisiac. Whether the effects of cocaine on EEG activity and penile erection are mechanistically linked, however, remains to be fully elucidated. We evaluated whether this link exists, based on simultaneous recording of EEG signals from the somatosensory cortex and intracavernous pressure (ICP, as experimental index for penile erection) in adult, male Sprague-Dawley rats. Under intraperitoneal chloral hydrate anesthesia (400 mg/kg, i.p.), both intravenous (i.v.) and intracavernous (i.c.) administration of cocaine (1.5 or 3.0 mg/kg, and 75 or 150 μg) dose-dependently induced discernible EEG desynchronization, as represented by a decrease in root mean square and an increase in mean power frequency values, and an increase in ICP. However, the same administration of cocaine in animals under pentobarbital sodium anesthesia (50 mg/kg, i.p.) failed to significantly affect EEG activity, despite an appreciable dose-dependent elevation in ICP. On the other hand, intracerebroventricular administration of cocaine (7.5, 15, or 30 μg) induced significant EEG activation without affecting ICP. I.c. application of papaverine (400 μg) elicited a discernible increase in ICP, but failed to evoke EEG desynchronization. These results suggest that the concurrent EEG desynchronization and penile erection elicited by cocaine may take place without a mutually causative relationship.

KW - Intracavernous pressure

KW - Mean power frequency

KW - Power spectral analysis

KW - Root mean square

UR - http://www.scopus.com/inward/record.url?scp=0029855885&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029855885&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1098-2396(199611)24:3<233::AID-SYN5>3.0.CO;2-F

DO - 10.1002/(SICI)1098-2396(199611)24:3<233::AID-SYN5>3.0.CO;2-F

M3 - Article

VL - 24

SP - 233

EP - 239

JO - Synapse

JF - Synapse

SN - 0887-4476

IS - 3

ER -