Abstract
Objective: This study aimed to evaluate the conceptual structure of the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (EORTC QLQ-C30) by analyzing data collected from patients with major cancers in Taiwan. The conceptual structure underlying QLQ-C30, including higher-order factors, was explored by structural equation modeling (SEM). Methods: The Taiwan Chinese version of the EORTC QLQ-C30 was used as the measuring instrument. Higher-order models, including mental health/physical health, mental function/physical burden, symptom burden/function, single latent health-related quality of life, formative symptom burden/function, and formative health-related quality of life, were tested. Results: Study subjects included 283 patients with breast, lung, and nasopharyngeal cancers. The original QLQ-C30 multi-factorial structure demonstrated poor composite reliability of the cognitive function subscale. The formative symptom/burden model was favored by model fit indices, further supporting causal–indicator duality, but was compromised by unexpected associations between symptomatic subscales and latent factors. The formative health-related quality of life was proposed with a single second-order latent factor where symptomatic subscales remained formative. Two additional symptom measures from the formal cognitive function subscale with the formative health-related quality-of-life model were proposed as the alterative conceptual structure for the Taiwan Chinese QLQ-C30. Conclusions: Results of the current study represent the complete SEM approach for the EORTC QLQ-C30. The formative health-related quality-of-life model with elimination of cognitive function enhances the conceptual structure of the Taiwan Chinese version with parsimonious fit and interpretability.
| Original language | English |
|---|---|
| Pages (from-to) | 1999-2013 |
| Number of pages | 15 |
| Journal | Quality of Life Research |
| Volume | 24 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Jan 6 2015 |
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Keywords
- Cancer
- Conceptual structure
- EORTC QLQ-C30
- Higher-order factor
- Quality of life
- Taiwan Chinese
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
Cite this
Conceptual structure of the Taiwan Chinese version of the EORTC QLQ-C30. / Huang, Chi Cheng; Tu, Shih Hsin; Lien, Heng Hui; Huang, Ching Shui; Wang, Pa Chun; Chie, Wei Chu.
In: Quality of Life Research, Vol. 24, No. 8, 06.01.2015, p. 1999-2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Conceptual structure of the Taiwan Chinese version of the EORTC QLQ-C30
AU - Huang, Chi Cheng
AU - Tu, Shih Hsin
AU - Lien, Heng Hui
AU - Huang, Ching Shui
AU - Wang, Pa Chun
AU - Chie, Wei Chu
PY - 2015/1/6
Y1 - 2015/1/6
N2 - Objective: This study aimed to evaluate the conceptual structure of the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (EORTC QLQ-C30) by analyzing data collected from patients with major cancers in Taiwan. The conceptual structure underlying QLQ-C30, including higher-order factors, was explored by structural equation modeling (SEM). Methods: The Taiwan Chinese version of the EORTC QLQ-C30 was used as the measuring instrument. Higher-order models, including mental health/physical health, mental function/physical burden, symptom burden/function, single latent health-related quality of life, formative symptom burden/function, and formative health-related quality of life, were tested. Results: Study subjects included 283 patients with breast, lung, and nasopharyngeal cancers. The original QLQ-C30 multi-factorial structure demonstrated poor composite reliability of the cognitive function subscale. The formative symptom/burden model was favored by model fit indices, further supporting causal–indicator duality, but was compromised by unexpected associations between symptomatic subscales and latent factors. The formative health-related quality of life was proposed with a single second-order latent factor where symptomatic subscales remained formative. Two additional symptom measures from the formal cognitive function subscale with the formative health-related quality-of-life model were proposed as the alterative conceptual structure for the Taiwan Chinese QLQ-C30. Conclusions: Results of the current study represent the complete SEM approach for the EORTC QLQ-C30. The formative health-related quality-of-life model with elimination of cognitive function enhances the conceptual structure of the Taiwan Chinese version with parsimonious fit and interpretability.
AB - Objective: This study aimed to evaluate the conceptual structure of the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (EORTC QLQ-C30) by analyzing data collected from patients with major cancers in Taiwan. The conceptual structure underlying QLQ-C30, including higher-order factors, was explored by structural equation modeling (SEM). Methods: The Taiwan Chinese version of the EORTC QLQ-C30 was used as the measuring instrument. Higher-order models, including mental health/physical health, mental function/physical burden, symptom burden/function, single latent health-related quality of life, formative symptom burden/function, and formative health-related quality of life, were tested. Results: Study subjects included 283 patients with breast, lung, and nasopharyngeal cancers. The original QLQ-C30 multi-factorial structure demonstrated poor composite reliability of the cognitive function subscale. The formative symptom/burden model was favored by model fit indices, further supporting causal–indicator duality, but was compromised by unexpected associations between symptomatic subscales and latent factors. The formative health-related quality of life was proposed with a single second-order latent factor where symptomatic subscales remained formative. Two additional symptom measures from the formal cognitive function subscale with the formative health-related quality-of-life model were proposed as the alterative conceptual structure for the Taiwan Chinese QLQ-C30. Conclusions: Results of the current study represent the complete SEM approach for the EORTC QLQ-C30. The formative health-related quality-of-life model with elimination of cognitive function enhances the conceptual structure of the Taiwan Chinese version with parsimonious fit and interpretability.
KW - Cancer
KW - Conceptual structure
KW - EORTC QLQ-C30
KW - Higher-order factor
KW - Quality of life
KW - Taiwan Chinese
UR - http://www.scopus.com/inward/record.url?scp=84937250489&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84937250489&partnerID=8YFLogxK
U2 - 10.1007/s11136-014-0913-3
DO - 10.1007/s11136-014-0913-3
M3 - Article
C2 - 25560775
AN - SCOPUS:84937250489
VL - 24
SP - 1999
EP - 2013
JO - Quality of Life Research
JF - Quality of Life Research
SN - 0962-9343
IS - 8
ER -