Concentrations of serum interleukin-8 after successful cardiopulmonary resuscitation in patients with cardiopulmonary arrest

K. G. Shyu, H. Chang, C. C. Lin, F. Y. Huang, C. R. Hung

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

To assess differences in serum interleukin-8 concentrations in resuscitated and nonresuscitated patients after cardiopulmonary resuscitation (CPR), and to compare changes of interleukin-8 levels with hemodynamic variables after restoration of spontaneous circulation, 39 patients with out- of-hospital cardiopulmonary arrest who had undergone CPR were studied. Venous blood samples were taken after CPR and 1 and 2 hours after restoration of spontaneous circulation to measure serum interleukin-8 levels by the enzyme- linked immunosorbent assay method. The median serum interleukin-8 levels after CPR were significantly higher in resuscitated than in nonresuscitated patients (64.9 pg/ml; range 30.2 to 1497 vs 0 pg/ml; range 0 to 31.6 pg/ml; p <0.001). One and 2 hours after restoration of spontaneous circulation, the median serum interleukin-8 levels were 96.2 pg/ml and 155.4 pg/ml, respectively. Mean values of systolic blood pressure immediately after and 1 and 2 hours after restoration of spontaneous circulation were 117 ± 9 mm Hg, 130 ± 11 mm Hg, and 136 ± 13 mm Hg, respectively. No significant correlations were found between hemodynamic values and serum interleukin-8 levels. In conclusion, successful initial resuscitation was associated with increased serum interleukin-8 concentrations. The interleukin-8 levels remained at high values 2 hours after restoration of spontaneous circulation.

Original languageEnglish
Pages (from-to)551-556
Number of pages6
JournalAmerican Heart Journal
Volume134
Issue number3
DOIs
Publication statusPublished - 1997
Externally publishedYes

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Cardiopulmonary Resuscitation
Heart Arrest
Interleukin-8
Serum
Hemodynamics
Blood Pressure
Resuscitation
Enzyme-Linked Immunosorbent Assay

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Concentrations of serum interleukin-8 after successful cardiopulmonary resuscitation in patients with cardiopulmonary arrest. / Shyu, K. G.; Chang, H.; Lin, C. C.; Huang, F. Y.; Hung, C. R.

In: American Heart Journal, Vol. 134, No. 3, 1997, p. 551-556.

Research output: Contribution to journalArticle

Shyu, K. G. ; Chang, H. ; Lin, C. C. ; Huang, F. Y. ; Hung, C. R. / Concentrations of serum interleukin-8 after successful cardiopulmonary resuscitation in patients with cardiopulmonary arrest. In: American Heart Journal. 1997 ; Vol. 134, No. 3. pp. 551-556.
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