Concentration of non-steroidal anti-inflammatory drugs in the pelvic floor muscles: An experimental comparative rat model

Hung Yen Chin, Eileen Changchien, Mei Fung Lin, Chi Hsin Chiang, Chin Jung Wang

Research output: Contribution to journalArticle

Abstract

Purpose: The aim of this study is to explore non-steroid anti-inflammation drugs (NSAIDs) potency for pelvic floor muscle pain by measuring local concentration in a rat model. Materials and Methods: We used nine NSAIDs, including nabumetone, naproxen, ibuprofen, meloxicam, piroxicam, diclofenac potassium, etodolac, indomethacin, and sulindac, and 9 groups of female Wister rats. Each group of rats was fed with one kind of NSAID (2 mg/mL) for three consecutive days. Thereafter, one mL of blood and one gram of pelvic floor muscle were taken to measure drug pharmacokinetics, including partition coefficient, lipophilicity, elimination of half-life (T1/2) and muscle/plasma converting ratio (Css, muscle/Css, plasma). Results: Diclofenac potassium had the lowest T1/2 and the highest mean Css, muscle/Css, plasma (1.9 hours and 0.85±0.53, respectively). The mean Css, muscle/Css, plasma of sulindac, naproxen and ibuprofen were lower than other experimental NSAIDs. Conclusion: Diclofenac potassium had the highest disposition in pelvic floor muscle in a rat model. The finding implies that diclofenac potassium might be the choice for pain relief in pelvic muscle.

Original languageEnglish
Pages (from-to)1095-1100
Number of pages6
JournalYonsei Medical Journal
Volume55
Issue number4
DOIs
Publication statusPublished - Jan 1 2014

Fingerprint

Pelvic Floor
Anti-Inflammatory Agents
Diclofenac
Muscles
Pharmaceutical Preparations
Sulindac
Inflammation
Naproxen
nabumetone
Ibuprofen
meloxicam
Etodolac
Piroxicam
Myalgia
Indomethacin
Half-Life
Pharmacokinetics
Pain

Keywords

  • Chronic pelvic pain
  • Myofacial pain syndrome
  • Non-steroid anti-inflammation drugs
  • Pelvic floor muscle

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Concentration of non-steroidal anti-inflammatory drugs in the pelvic floor muscles : An experimental comparative rat model. / Chin, Hung Yen; Changchien, Eileen; Lin, Mei Fung; Chiang, Chi Hsin; Wang, Chin Jung.

In: Yonsei Medical Journal, Vol. 55, No. 4, 01.01.2014, p. 1095-1100.

Research output: Contribution to journalArticle

Chin, Hung Yen ; Changchien, Eileen ; Lin, Mei Fung ; Chiang, Chi Hsin ; Wang, Chin Jung. / Concentration of non-steroidal anti-inflammatory drugs in the pelvic floor muscles : An experimental comparative rat model. In: Yonsei Medical Journal. 2014 ; Vol. 55, No. 4. pp. 1095-1100.
@article{51bcfff819f647d080ee3011c1d226e4,
title = "Concentration of non-steroidal anti-inflammatory drugs in the pelvic floor muscles: An experimental comparative rat model",
abstract = "Purpose: The aim of this study is to explore non-steroid anti-inflammation drugs (NSAIDs) potency for pelvic floor muscle pain by measuring local concentration in a rat model. Materials and Methods: We used nine NSAIDs, including nabumetone, naproxen, ibuprofen, meloxicam, piroxicam, diclofenac potassium, etodolac, indomethacin, and sulindac, and 9 groups of female Wister rats. Each group of rats was fed with one kind of NSAID (2 mg/mL) for three consecutive days. Thereafter, one mL of blood and one gram of pelvic floor muscle were taken to measure drug pharmacokinetics, including partition coefficient, lipophilicity, elimination of half-life (T1/2) and muscle/plasma converting ratio (Css, muscle/Css, plasma). Results: Diclofenac potassium had the lowest T1/2 and the highest mean Css, muscle/Css, plasma (1.9 hours and 0.85±0.53, respectively). The mean Css, muscle/Css, plasma of sulindac, naproxen and ibuprofen were lower than other experimental NSAIDs. Conclusion: Diclofenac potassium had the highest disposition in pelvic floor muscle in a rat model. The finding implies that diclofenac potassium might be the choice for pain relief in pelvic muscle.",
keywords = "Chronic pelvic pain, Myofacial pain syndrome, Non-steroid anti-inflammation drugs, Pelvic floor muscle, Chronic pelvic pain, Myofacial pain syndrome, Non-steroid anti-inflammation drugs, Pelvic floor muscle",
author = "Chin, {Hung Yen} and Eileen Changchien and Lin, {Mei Fung} and Chiang, {Chi Hsin} and Wang, {Chin Jung}",
year = "2014",
month = "1",
day = "1",
doi = "10.3349/ymj.2014.55.4.1095",
language = "English",
volume = "55",
pages = "1095--1100",
journal = "Yonsei Medical Journal",
issn = "0513-5796",
publisher = "Yonsei University College of Medicine",
number = "4",

}

TY - JOUR

T1 - Concentration of non-steroidal anti-inflammatory drugs in the pelvic floor muscles

T2 - An experimental comparative rat model

AU - Chin, Hung Yen

AU - Changchien, Eileen

AU - Lin, Mei Fung

AU - Chiang, Chi Hsin

AU - Wang, Chin Jung

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Purpose: The aim of this study is to explore non-steroid anti-inflammation drugs (NSAIDs) potency for pelvic floor muscle pain by measuring local concentration in a rat model. Materials and Methods: We used nine NSAIDs, including nabumetone, naproxen, ibuprofen, meloxicam, piroxicam, diclofenac potassium, etodolac, indomethacin, and sulindac, and 9 groups of female Wister rats. Each group of rats was fed with one kind of NSAID (2 mg/mL) for three consecutive days. Thereafter, one mL of blood and one gram of pelvic floor muscle were taken to measure drug pharmacokinetics, including partition coefficient, lipophilicity, elimination of half-life (T1/2) and muscle/plasma converting ratio (Css, muscle/Css, plasma). Results: Diclofenac potassium had the lowest T1/2 and the highest mean Css, muscle/Css, plasma (1.9 hours and 0.85±0.53, respectively). The mean Css, muscle/Css, plasma of sulindac, naproxen and ibuprofen were lower than other experimental NSAIDs. Conclusion: Diclofenac potassium had the highest disposition in pelvic floor muscle in a rat model. The finding implies that diclofenac potassium might be the choice for pain relief in pelvic muscle.

AB - Purpose: The aim of this study is to explore non-steroid anti-inflammation drugs (NSAIDs) potency for pelvic floor muscle pain by measuring local concentration in a rat model. Materials and Methods: We used nine NSAIDs, including nabumetone, naproxen, ibuprofen, meloxicam, piroxicam, diclofenac potassium, etodolac, indomethacin, and sulindac, and 9 groups of female Wister rats. Each group of rats was fed with one kind of NSAID (2 mg/mL) for three consecutive days. Thereafter, one mL of blood and one gram of pelvic floor muscle were taken to measure drug pharmacokinetics, including partition coefficient, lipophilicity, elimination of half-life (T1/2) and muscle/plasma converting ratio (Css, muscle/Css, plasma). Results: Diclofenac potassium had the lowest T1/2 and the highest mean Css, muscle/Css, plasma (1.9 hours and 0.85±0.53, respectively). The mean Css, muscle/Css, plasma of sulindac, naproxen and ibuprofen were lower than other experimental NSAIDs. Conclusion: Diclofenac potassium had the highest disposition in pelvic floor muscle in a rat model. The finding implies that diclofenac potassium might be the choice for pain relief in pelvic muscle.

KW - Chronic pelvic pain

KW - Myofacial pain syndrome

KW - Non-steroid anti-inflammation drugs

KW - Pelvic floor muscle

KW - Chronic pelvic pain

KW - Myofacial pain syndrome

KW - Non-steroid anti-inflammation drugs

KW - Pelvic floor muscle

UR - http://www.scopus.com/inward/record.url?scp=84903188466&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903188466&partnerID=8YFLogxK

U2 - 10.3349/ymj.2014.55.4.1095

DO - 10.3349/ymj.2014.55.4.1095

M3 - Article

C2 - 24954342

AN - SCOPUS:84903188466

VL - 55

SP - 1095

EP - 1100

JO - Yonsei Medical Journal

JF - Yonsei Medical Journal

SN - 0513-5796

IS - 4

ER -