Concentration of non-steroidal anti-inflammatory drugs in the pelvic floor muscles: An experimental comparative rat model

Hung Yen Chin, Eileen Changchien, Mei Fung Lin, Chi Hsin Chiang, Chin Jung Wang

Research output: Contribution to journalArticle

Abstract

Purpose: The aim of this study is to explore non-steroid anti-inflammation drugs (NSAIDs) potency for pelvic floor muscle pain by measuring local concentration in a rat model. Materials and Methods: We used nine NSAIDs, including nabumetone, naproxen, ibuprofen, meloxicam, piroxicam, diclofenac potassium, etodolac, indomethacin, and sulindac, and 9 groups of female Wister rats. Each group of rats was fed with one kind of NSAID (2 mg/mL) for three consecutive days. Thereafter, one mL of blood and one gram of pelvic floor muscle were taken to measure drug pharmacokinetics, including partition coefficient, lipophilicity, elimination of half-life (T1/2) and muscle/plasma converting ratio (Css, muscle/Css, plasma). Results: Diclofenac potassium had the lowest T1/2 and the highest mean Css, muscle/Css, plasma (1.9 hours and 0.85±0.53, respectively). The mean Css, muscle/Css, plasma of sulindac, naproxen and ibuprofen were lower than other experimental NSAIDs. Conclusion: Diclofenac potassium had the highest disposition in pelvic floor muscle in a rat model. The finding implies that diclofenac potassium might be the choice for pain relief in pelvic muscle.

Original languageEnglish
Pages (from-to)1095-1100
Number of pages6
JournalYonsei Medical Journal
Volume55
Issue number4
DOIs
Publication statusPublished - Jan 1 2014

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Keywords

  • Chronic pelvic pain
  • Myofacial pain syndrome
  • Non-steroid anti-inflammation drugs
  • Pelvic floor muscle

ASJC Scopus subject areas

  • Medicine(all)

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