Compressive loading at the end plate directly regulates flow and deformation of the basivertebral vein

An analytical study

Ming Long Yeh, Michael H. Heggeness, Hsiang Ho Chen, Jennifer Jassawalla, Zong Ping Luo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Metastatic diseases and infections frequently involve the spine. This is the result of seeding of the vertebral body by tumor cells or bacteria delivered by venous blood from Batson's plexus, which is hypothesized to enter the vertebral body via the epidural veins. Isolated spinal segments deform significantly at the bony end plate when under compression. This deformation could cause a volume change of the vertebral body and may be accompanied by retrograde flow of venous blood. To date, this process has not been investigated quantitatively. The purpose of this study was to determine the volume changes of the vertebral body and basivertebral vein for a vertebral body under compression. Methods: A three-dimensional finite element mesh model of the L4 segment with both adjacent discs was modified from a 3-D computed tomography scan image. An octagon representing the basivertebral vein was introduced into the center of the vertebral body in the model. Four compressive orientations (1500 N) were applied on the top disc. The volume change of the vertebral body model and the basivertebral vein were then computed. Results: The volume change of the vertebral body was about 0.1 cm3 (16.3% of the basivertebral vein) for the four loading conditions. The maximum cross-sectional area reductions of the basivertebral vein and volume reduction were 1.54% and 1.02%, for uniform compression. Conclusion: Our study quantified the small but significant volume change of a modeled vertebral body and cross-sectional areas and that of the basivertebral vein, due to the inward bulging of the end plate under compression. This volume change could initiate the reverse flow of blood from the epidural venous system and cause seeding of tumors or bacterial cells.

Original languageEnglish
Article number18
JournalJournal of Orthopaedic Surgery and Research
Volume1
Issue number1
DOIs
Publication statusPublished - 2006
Externally publishedYes

Fingerprint

Veins
Neoplasms
Spine
Tomography
Bacteria
Infection

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Compressive loading at the end plate directly regulates flow and deformation of the basivertebral vein : An analytical study. / Yeh, Ming Long; Heggeness, Michael H.; Chen, Hsiang Ho; Jassawalla, Jennifer; Luo, Zong Ping.

In: Journal of Orthopaedic Surgery and Research, Vol. 1, No. 1, 18, 2006.

Research output: Contribution to journalArticle

@article{31c2a2e791c24a3b8cd26b992f1e08c7,
title = "Compressive loading at the end plate directly regulates flow and deformation of the basivertebral vein: An analytical study",
abstract = "Background: Metastatic diseases and infections frequently involve the spine. This is the result of seeding of the vertebral body by tumor cells or bacteria delivered by venous blood from Batson's plexus, which is hypothesized to enter the vertebral body via the epidural veins. Isolated spinal segments deform significantly at the bony end plate when under compression. This deformation could cause a volume change of the vertebral body and may be accompanied by retrograde flow of venous blood. To date, this process has not been investigated quantitatively. The purpose of this study was to determine the volume changes of the vertebral body and basivertebral vein for a vertebral body under compression. Methods: A three-dimensional finite element mesh model of the L4 segment with both adjacent discs was modified from a 3-D computed tomography scan image. An octagon representing the basivertebral vein was introduced into the center of the vertebral body in the model. Four compressive orientations (1500 N) were applied on the top disc. The volume change of the vertebral body model and the basivertebral vein were then computed. Results: The volume change of the vertebral body was about 0.1 cm3 (16.3{\%} of the basivertebral vein) for the four loading conditions. The maximum cross-sectional area reductions of the basivertebral vein and volume reduction were 1.54{\%} and 1.02{\%}, for uniform compression. Conclusion: Our study quantified the small but significant volume change of a modeled vertebral body and cross-sectional areas and that of the basivertebral vein, due to the inward bulging of the end plate under compression. This volume change could initiate the reverse flow of blood from the epidural venous system and cause seeding of tumors or bacterial cells.",
author = "Yeh, {Ming Long} and Heggeness, {Michael H.} and Chen, {Hsiang Ho} and Jennifer Jassawalla and Luo, {Zong Ping}",
year = "2006",
doi = "10.1186/1749-799X-1-18",
language = "English",
volume = "1",
journal = "Journal of Orthopaedic Surgery and Research",
issn = "1749-799X",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Compressive loading at the end plate directly regulates flow and deformation of the basivertebral vein

T2 - An analytical study

AU - Yeh, Ming Long

AU - Heggeness, Michael H.

AU - Chen, Hsiang Ho

AU - Jassawalla, Jennifer

AU - Luo, Zong Ping

PY - 2006

Y1 - 2006

N2 - Background: Metastatic diseases and infections frequently involve the spine. This is the result of seeding of the vertebral body by tumor cells or bacteria delivered by venous blood from Batson's plexus, which is hypothesized to enter the vertebral body via the epidural veins. Isolated spinal segments deform significantly at the bony end plate when under compression. This deformation could cause a volume change of the vertebral body and may be accompanied by retrograde flow of venous blood. To date, this process has not been investigated quantitatively. The purpose of this study was to determine the volume changes of the vertebral body and basivertebral vein for a vertebral body under compression. Methods: A three-dimensional finite element mesh model of the L4 segment with both adjacent discs was modified from a 3-D computed tomography scan image. An octagon representing the basivertebral vein was introduced into the center of the vertebral body in the model. Four compressive orientations (1500 N) were applied on the top disc. The volume change of the vertebral body model and the basivertebral vein were then computed. Results: The volume change of the vertebral body was about 0.1 cm3 (16.3% of the basivertebral vein) for the four loading conditions. The maximum cross-sectional area reductions of the basivertebral vein and volume reduction were 1.54% and 1.02%, for uniform compression. Conclusion: Our study quantified the small but significant volume change of a modeled vertebral body and cross-sectional areas and that of the basivertebral vein, due to the inward bulging of the end plate under compression. This volume change could initiate the reverse flow of blood from the epidural venous system and cause seeding of tumors or bacterial cells.

AB - Background: Metastatic diseases and infections frequently involve the spine. This is the result of seeding of the vertebral body by tumor cells or bacteria delivered by venous blood from Batson's plexus, which is hypothesized to enter the vertebral body via the epidural veins. Isolated spinal segments deform significantly at the bony end plate when under compression. This deformation could cause a volume change of the vertebral body and may be accompanied by retrograde flow of venous blood. To date, this process has not been investigated quantitatively. The purpose of this study was to determine the volume changes of the vertebral body and basivertebral vein for a vertebral body under compression. Methods: A three-dimensional finite element mesh model of the L4 segment with both adjacent discs was modified from a 3-D computed tomography scan image. An octagon representing the basivertebral vein was introduced into the center of the vertebral body in the model. Four compressive orientations (1500 N) were applied on the top disc. The volume change of the vertebral body model and the basivertebral vein were then computed. Results: The volume change of the vertebral body was about 0.1 cm3 (16.3% of the basivertebral vein) for the four loading conditions. The maximum cross-sectional area reductions of the basivertebral vein and volume reduction were 1.54% and 1.02%, for uniform compression. Conclusion: Our study quantified the small but significant volume change of a modeled vertebral body and cross-sectional areas and that of the basivertebral vein, due to the inward bulging of the end plate under compression. This volume change could initiate the reverse flow of blood from the epidural venous system and cause seeding of tumors or bacterial cells.

UR - http://www.scopus.com/inward/record.url?scp=34248163355&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34248163355&partnerID=8YFLogxK

U2 - 10.1186/1749-799X-1-18

DO - 10.1186/1749-799X-1-18

M3 - Article

VL - 1

JO - Journal of Orthopaedic Surgery and Research

JF - Journal of Orthopaedic Surgery and Research

SN - 1749-799X

IS - 1

M1 - 18

ER -