Compound Cordyceps TCM-700C exhibits potent hepatoprotective capability in animal model

Wang Sheng Ko, Shih Lan Hsu, Charng Cherng Chyau, Kuan Chou Chen, Robert Y. Peng

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A herbal preparation "Compound Codyceps-TCM-700C (CC-700C)" was tested for hepatoprotective effect against the carbon tetrachloride induced liver damages in Sprague-Dawley rat model for a period of 6-weeks. Two dosage levels of CC-700C, respectively 286.2 mg/kg-bw (L-TCM) and 2862 mg/kg-bw (H-TCM), and a positive control Silymarin (Sigma) were used to compare their therapeutic effect. Both CC-700C's and Silymarin showed nontoxic in nature, as evidenced by body weight gain, organ weights and appearance including liver, spleen, and kidney. The activities of aspartate aminotransferase (AST) and alanine-aminotransferase (ALT) were more effectively suppressed by CC-700C than Silymarin. In addition, all levels of serum bilirubin, serum albumin, triglyceride (TG), total cholesterol (TC), platelet count (PLT), and prothombin time (PT) except TG were shown effectively restored to normal values by CC-700C and Silymarin. Moreover, although levels of glutathione (GSH), glutathione reductase (GSH-Rd), and superoxide dismutase (SOD) were equally maintained by these three preparations, glutathione peroxidase (GSH-Px) was suppressed only by H-TCM, and SOD only by Silymarin. In contrast, the activity of catalase efficiently recovered to control level on administration of CC-700C, being far better than Silymarin. Finally the liver collagen content, an indication of fibrosis, was also significantly suppressed by CC-700C, better effect was by L-TCM, but both levels were superior to Silymarin. Conclusively, the herbal preparation "Compound Cordyceps TCM-700C" is a potent hepatoprotective preparation. For therapeutic use, a dosage of 286.2 mg/kg-bw would be sufficiently effective.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalFitoterapia
Volume81
Issue number1
DOIs
Publication statusPublished - Jan 2010

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Cordyceps
Silymarin
Animal Models
Plant Preparations
Therapeutic Uses
Superoxide Dismutase
Liver
Triglycerides
Organ Size
Glutathione Reductase
Carbon Tetrachloride
Glutathione Peroxidase
Aspartate Aminotransferases
Alanine Transaminase
Platelet Count
Bilirubin
Serum Albumin
Catalase
Weight Gain
Glutathione

Keywords

  • Codyceps-TCM-700C
  • Hepatoprotective
  • Silymarin
  • Sprague-Dawley rat

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Compound Cordyceps TCM-700C exhibits potent hepatoprotective capability in animal model. / Ko, Wang Sheng; Hsu, Shih Lan; Chyau, Charng Cherng; Chen, Kuan Chou; Peng, Robert Y.

In: Fitoterapia, Vol. 81, No. 1, 01.2010, p. 1-7.

Research output: Contribution to journalArticle

Ko, Wang Sheng ; Hsu, Shih Lan ; Chyau, Charng Cherng ; Chen, Kuan Chou ; Peng, Robert Y. / Compound Cordyceps TCM-700C exhibits potent hepatoprotective capability in animal model. In: Fitoterapia. 2010 ; Vol. 81, No. 1. pp. 1-7.
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AB - A herbal preparation "Compound Codyceps-TCM-700C (CC-700C)" was tested for hepatoprotective effect against the carbon tetrachloride induced liver damages in Sprague-Dawley rat model for a period of 6-weeks. Two dosage levels of CC-700C, respectively 286.2 mg/kg-bw (L-TCM) and 2862 mg/kg-bw (H-TCM), and a positive control Silymarin (Sigma) were used to compare their therapeutic effect. Both CC-700C's and Silymarin showed nontoxic in nature, as evidenced by body weight gain, organ weights and appearance including liver, spleen, and kidney. The activities of aspartate aminotransferase (AST) and alanine-aminotransferase (ALT) were more effectively suppressed by CC-700C than Silymarin. In addition, all levels of serum bilirubin, serum albumin, triglyceride (TG), total cholesterol (TC), platelet count (PLT), and prothombin time (PT) except TG were shown effectively restored to normal values by CC-700C and Silymarin. Moreover, although levels of glutathione (GSH), glutathione reductase (GSH-Rd), and superoxide dismutase (SOD) were equally maintained by these three preparations, glutathione peroxidase (GSH-Px) was suppressed only by H-TCM, and SOD only by Silymarin. In contrast, the activity of catalase efficiently recovered to control level on administration of CC-700C, being far better than Silymarin. Finally the liver collagen content, an indication of fibrosis, was also significantly suppressed by CC-700C, better effect was by L-TCM, but both levels were superior to Silymarin. Conclusively, the herbal preparation "Compound Cordyceps TCM-700C" is a potent hepatoprotective preparation. For therapeutic use, a dosage of 286.2 mg/kg-bw would be sufficiently effective.

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