Complex mutation patterns of epidermal growth factor receptor gene associated with variable responses to gefitinib treatment in patients with non-small cell lung cancer

Meng Heng Hsieh, Yueh Fu Fang, Wen Cheng Chang, Han Pin Kuo, Shinn Yn Lin, Hui Ping Liu, Chih Lin Liu, Hsiu Chi Chen, Yuan Chieh Ku, Ya Ting Chen, Ya Hui Chang, Ying Tsong Chen, Bae Li Hsi, Shih Feng Tsai, Shiu Feng Huang

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Mutational analysis was performed in the kinase domain (exons 18-21) of the EGFR gene on tumor tissues of 65 non-small cell lung cancer (NSCLC) patients who had received gefitinib monotherapy. The association between EGFR gene mutation, gefitinib treatment response, and the overall survival were evaluated. In total, EGFR mutations with complex patterns were identified in 32 tumors. The overall mutation rate was 49.2% (32/65). Twenty of the 32 patients were responders, 10 non-responders, and 2 not assessable. The most common mutation in non-responders was L858R. Gefitinib responsiveness was only significantly associated with EGFR mutation and adenocarcinoma. The median survival for responder (15.5 months) was much longer than non-responder (9.23 months), though the difference only had marginal significance (p = 0.056). The difference of overall survival between patients with and without EGFR mutation was non-significant (p = 0.7819), mainly due to the short survival of the non-responders with EGFR mutations (median survival = 6.2 months). Our study revealed that the response to gefitinib treatment in NSCLC patients with EGFR mutations could be quite variable even for the same EGFR mutation type. An analysis of the various EGFR mutations and the response patterns was also performed and compared with recently published reports on EGFR mutation and gefitinib responsiveness.

Original languageEnglish
Pages (from-to)311-322
Number of pages12
JournalLung Cancer
Volume53
Issue number3
DOIs
Publication statusPublished - Sep 1 2006
Externally publishedYes

Keywords

  • EGFR
  • Gefitinib
  • Lung cancer
  • Mutation
  • NSCLC

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

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  • Cite this

    Hsieh, M. H., Fang, Y. F., Chang, W. C., Kuo, H. P., Lin, S. Y., Liu, H. P., Liu, C. L., Chen, H. C., Ku, Y. C., Chen, Y. T., Chang, Y. H., Chen, Y. T., Hsi, B. L., Tsai, S. F., & Huang, S. F. (2006). Complex mutation patterns of epidermal growth factor receptor gene associated with variable responses to gefitinib treatment in patients with non-small cell lung cancer. Lung Cancer, 53(3), 311-322. https://doi.org/10.1016/j.lungcan.2006.06.005