Complex behaviors related to zolpidem: An analysis of published clinical cases from Taiwan

Ana Isabel Wu-Chou, Winston W. Shen

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: Benzodiazepines with a unique chemical structure of three-ring diabenzine can induce the benzodiazepine-gamma aminobutyric acid A receptor complex to produce sedative, anxiolytic, muscle-relaxant, and anticonvulsant effects. But they have serious side effects such as tolerance and withdrawal, memory and performance impairments, and complex behaviors associated with amnesia. Method: We searched zolpidem-related published papers from Taiwan from 2003 to 2011. All bibliographical data of original clinical reports were studied. We focused only on complex behaviors related to zolpidem and not on the symptoms of zolpidem-related addiction, tolerance, and withdrawal. Results: The search in PubMed with the keyword " zolpidem" yielded 729 articles published from 2003 to 2011. Of these, 20 articles were written by Taiwanese author(s). There were 15 case reports and five clinical studies. Besides the symptoms of addiction, tolerance, and withdrawal, these papers describe complex behavioral disturbances, such as performance impairments, behavioral impairment with amnesia, sleepwalking, sleep-related eating disorder, and hallucination and sensory distortion. Conclusion: We have summarized the case reports and clinical studies of zolpidem-related adverse effects published from Taiwan and reviewed concerns about zolpidem's safety that international researchers have been voicing out in recent years. The incidence of those zolpidem-induced complex behaviors is similar to that found in Western countries. Clinicians should therefore use more antidepressants to treat the underlying diseases that present with insomnia (such as major depressive disorder or generalized anxiety disorder).

Original languageEnglish
Pages (from-to)113-118
Number of pages6
JournalJournal of Experimental and Clinical Medicine
Volume4
Issue number2
DOIs
Publication statusPublished - Apr 2012

Fingerprint

Taiwan
Amnesia
Benzodiazepines
Somnambulism
GABA Receptors
Hallucinations
Anti-Anxiety Agents
Major Depressive Disorder
Sleep Initiation and Maintenance Disorders
zolpidem
Anxiety Disorders
Hypnotics and Sedatives
PubMed
Anticonvulsants
Antidepressive Agents
Sleep
Research Personnel
Safety
Muscles
Incidence

Keywords

  • Adverse drug events
  • Anterograde amnesia
  • Sleep-related complex behaviors
  • Sleep-related eating syndrome
  • Sleepwalking
  • Zolpidem

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Complex behaviors related to zolpidem : An analysis of published clinical cases from Taiwan. / Wu-Chou, Ana Isabel; Shen, Winston W.

In: Journal of Experimental and Clinical Medicine, Vol. 4, No. 2, 04.2012, p. 113-118.

Research output: Contribution to journalArticle

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