Complete sequences of two plasmids in a blandm-1-positive klebsiella oxytoca isolate from taiwan

Tzu Wen Huang, Jann Tay Wang, Tsai Ling Lauderdale, Tsai Lien Liao, Jui Fen Lai, Mei Chen Tan, Ann Chi Lin, Ying Tsong Chen, Shih Feng Tsai, Shan Chwen Chang

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Genetic determinants of a blaNDM-1-positive, multidrug-resistant bacterial isolate that caused active infection was investigated by DNA sequencing. Two plasmids, pKOX-NDM1 and pKOX-R1, were identified for the Klebsiella oxytoca strain E718. Sequence annotation revealed a blaNDM-1 gene in pKOX-NDM1 and two extended-spectrum-lactamase producers (blaCTX-M-3 and blaSHV-12) and a wide array of resistance genes in pKOX-R1. These findings highlight the difficulty in treating multidrugresistant bacterial infections and the potential danger of emerging resistant enterobacteria.

Original languageEnglish
Pages (from-to)4072-4076
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume57
Issue number8
DOIs
Publication statusPublished - Aug 2013
Externally publishedYes

Fingerprint

Klebsiella oxytoca
Taiwan
Plasmids
Enterobacteriaceae
DNA Sequence Analysis
Bacterial Infections
Genes
Infection

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

Complete sequences of two plasmids in a blandm-1-positive klebsiella oxytoca isolate from taiwan. / Huang, Tzu Wen; Wang, Jann Tay; Lauderdale, Tsai Ling; Liao, Tsai Lien; Lai, Jui Fen; Tan, Mei Chen; Lin, Ann Chi; Chen, Ying Tsong; Tsai, Shih Feng; Chang, Shan Chwen.

In: Antimicrobial Agents and Chemotherapy, Vol. 57, No. 8, 08.2013, p. 4072-4076.

Research output: Contribution to journalArticle

Huang, TW, Wang, JT, Lauderdale, TL, Liao, TL, Lai, JF, Tan, MC, Lin, AC, Chen, YT, Tsai, SF & Chang, SC 2013, 'Complete sequences of two plasmids in a blandm-1-positive klebsiella oxytoca isolate from taiwan', Antimicrobial Agents and Chemotherapy, vol. 57, no. 8, pp. 4072-4076. https://doi.org/10.1128/AAC.02266-12
Huang, Tzu Wen ; Wang, Jann Tay ; Lauderdale, Tsai Ling ; Liao, Tsai Lien ; Lai, Jui Fen ; Tan, Mei Chen ; Lin, Ann Chi ; Chen, Ying Tsong ; Tsai, Shih Feng ; Chang, Shan Chwen. / Complete sequences of two plasmids in a blandm-1-positive klebsiella oxytoca isolate from taiwan. In: Antimicrobial Agents and Chemotherapy. 2013 ; Vol. 57, No. 8. pp. 4072-4076.
@article{a262b2c6e77e4020ba5e49809e656600,
title = "Complete sequences of two plasmids in a blandm-1-positive klebsiella oxytoca isolate from taiwan",
abstract = "Genetic determinants of a blaNDM-1-positive, multidrug-resistant bacterial isolate that caused active infection was investigated by DNA sequencing. Two plasmids, pKOX-NDM1 and pKOX-R1, were identified for the Klebsiella oxytoca strain E718. Sequence annotation revealed a blaNDM-1 gene in pKOX-NDM1 and two extended-spectrum-lactamase producers (blaCTX-M-3 and blaSHV-12) and a wide array of resistance genes in pKOX-R1. These findings highlight the difficulty in treating multidrugresistant bacterial infections and the potential danger of emerging resistant enterobacteria.",
author = "Huang, {Tzu Wen} and Wang, {Jann Tay} and Lauderdale, {Tsai Ling} and Liao, {Tsai Lien} and Lai, {Jui Fen} and Tan, {Mei Chen} and Lin, {Ann Chi} and Chen, {Ying Tsong} and Tsai, {Shih Feng} and Chang, {Shan Chwen}",
year = "2013",
month = "8",
doi = "10.1128/AAC.02266-12",
language = "English",
volume = "57",
pages = "4072--4076",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "8",

}

TY - JOUR

T1 - Complete sequences of two plasmids in a blandm-1-positive klebsiella oxytoca isolate from taiwan

AU - Huang, Tzu Wen

AU - Wang, Jann Tay

AU - Lauderdale, Tsai Ling

AU - Liao, Tsai Lien

AU - Lai, Jui Fen

AU - Tan, Mei Chen

AU - Lin, Ann Chi

AU - Chen, Ying Tsong

AU - Tsai, Shih Feng

AU - Chang, Shan Chwen

PY - 2013/8

Y1 - 2013/8

N2 - Genetic determinants of a blaNDM-1-positive, multidrug-resistant bacterial isolate that caused active infection was investigated by DNA sequencing. Two plasmids, pKOX-NDM1 and pKOX-R1, were identified for the Klebsiella oxytoca strain E718. Sequence annotation revealed a blaNDM-1 gene in pKOX-NDM1 and two extended-spectrum-lactamase producers (blaCTX-M-3 and blaSHV-12) and a wide array of resistance genes in pKOX-R1. These findings highlight the difficulty in treating multidrugresistant bacterial infections and the potential danger of emerging resistant enterobacteria.

AB - Genetic determinants of a blaNDM-1-positive, multidrug-resistant bacterial isolate that caused active infection was investigated by DNA sequencing. Two plasmids, pKOX-NDM1 and pKOX-R1, were identified for the Klebsiella oxytoca strain E718. Sequence annotation revealed a blaNDM-1 gene in pKOX-NDM1 and two extended-spectrum-lactamase producers (blaCTX-M-3 and blaSHV-12) and a wide array of resistance genes in pKOX-R1. These findings highlight the difficulty in treating multidrugresistant bacterial infections and the potential danger of emerging resistant enterobacteria.

UR - http://www.scopus.com/inward/record.url?scp=84880272508&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880272508&partnerID=8YFLogxK

U2 - 10.1128/AAC.02266-12

DO - 10.1128/AAC.02266-12

M3 - Article

C2 - 23752513

AN - SCOPUS:84880272508

VL - 57

SP - 4072

EP - 4076

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 8

ER -