Complete sequences of two plasmids in a blandm-1-positive klebsiella oxytoca isolate from taiwan

Tzu Wen Huang, Jann Tay Wang, Tsai Ling Lauderdale, Tsai Lien Liao, Jui Fen Lai, Mei Chen Tan, Ann Chi Lin, Ying Tsong Chen, Shih Feng Tsai, Shan Chwen Chang

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Genetic determinants of a blaNDM-1-positive, multidrug-resistant bacterial isolate that caused active infection was investigated by DNA sequencing. Two plasmids, pKOX-NDM1 and pKOX-R1, were identified for the Klebsiella oxytoca strain E718. Sequence annotation revealed a blaNDM-1 gene in pKOX-NDM1 and two extended-spectrum-lactamase producers (blaCTX-M-3 and blaSHV-12) and a wide array of resistance genes in pKOX-R1. These findings highlight the difficulty in treating multidrugresistant bacterial infections and the potential danger of emerging resistant enterobacteria.

Original languageEnglish
Pages (from-to)4072-4076
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume57
Issue number8
DOIs
Publication statusPublished - Aug 2013
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

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    Huang, T. W., Wang, J. T., Lauderdale, T. L., Liao, T. L., Lai, J. F., Tan, M. C., Lin, A. C., Chen, Y. T., Tsai, S. F., & Chang, S. C. (2013). Complete sequences of two plasmids in a blandm-1-positive klebsiella oxytoca isolate from taiwan. Antimicrobial Agents and Chemotherapy, 57(8), 4072-4076. https://doi.org/10.1128/AAC.02266-12