Comparisons of clinical impacts on individuals with Brugada electrocardiographic patterns defined by ISHNE criteria or EHRA/HRS/APHRS criteria

a nationwide community-based study

Ching Yu Julius Chen, Jyh Ming Jimmy Juang, Ying Hsiang Chen, I. Chien Wu, Chih Cheng Hsu, Ray Chin Wu, Kwo Ching Chen, Wen Jin Liaw, Tsung Lung Tsai, Lian Yu Lin, Juey Jen Hwang, Li Ting Ho, Chih Chien Yu, Jen Kuang Lee, Cho Kai Wu, Shih Fan Sherri Yeh, Dun Hui Yang, I. Shou Chang, Ling Ping Lai, Fu Tien Chiang & 2 others Jiunn Lee Lin, Chao Agnes Hsiung

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction: Identifying Brugada electrocardiographic pattern (BrP) early is crucial to prevent sudden cardiac death. Two different diagnostic criteria proposed by International Society for Holter and Noninvasive Electrocardiography (ISHNE) and Heart Rhythm Society/European Heart Rhythm Association/Asia-Pacific Heart Rhythm Society (HRS/EHRA/APHRS) were widely used in clinical practice. The difference in prevalence and prognosis of BrP by applying the two different criteria was never studied before. Methods: This study was prospectively conducted in a nationwide large-scale stratified random sampling community-based cohort (HALST) from Han Chinese population in Taiwan from December 2008 to December 2012. We compared the prevalence and prognosis of BrP defined by the two diagnostic criteria. Results: A total of 5214 adults were enrolled (2530 men) with mean age of 69.3 years. Four had spontaneous type 1 BrP (0.077%). By the HRS/EHRA/APHRS criteria, 68 individuals have type 2 BrP (1.30%) and 101 have type 3 BrP (1.94%) whereas by the ISHNE criteria, 46 individuals exhibited type 2 BrP (0.88%). When applying the ISHNE criteria, the number of individuals with BrP decreased by 71%. However, all-cause mortality and cardiovascular mortality were not different between individuals with or without BrP, irrespective of the criteria used. Conclusions: The two different criteria may impact the diagnostic yield of individuals with BrP, but do not affect the prognosis of the individuals with BrP.Key messages Comparing with the use of HRS/EHRA/APHRS criteria, the number of individuals with Brugada ECG patterns was decreased by 71% when applying the ISHNE criteria. The prognosis of individuals with Brugada ECG patterns defined by 2012 ISHNE or 2013 HRS/EHRA/APHRS criteria were not different.

Original languageEnglish
Pages (from-to)7-15
Number of pages9
JournalAnnals of Medicine
Volume50
Issue number1
DOIs
Publication statusPublished - Jan 2 2018
Externally publishedYes

Fingerprint

Ambulatory Electrocardiography
Brugada Syndrome
Mortality
Sudden Cardiac Death
Taiwan

Keywords

  • Brugada electrocardiographic patterns
  • community-based
  • Han Chinese population
  • long-term prognosis
  • Prevalence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Comparisons of clinical impacts on individuals with Brugada electrocardiographic patterns defined by ISHNE criteria or EHRA/HRS/APHRS criteria : a nationwide community-based study. / Chen, Ching Yu Julius; Juang, Jyh Ming Jimmy; Chen, Ying Hsiang; Wu, I. Chien; Hsu, Chih Cheng; Wu, Ray Chin; Chen, Kwo Ching; Liaw, Wen Jin; Tsai, Tsung Lung; Lin, Lian Yu; Hwang, Juey Jen; Ho, Li Ting; Yu, Chih Chien; Lee, Jen Kuang; Wu, Cho Kai; Yeh, Shih Fan Sherri; Yang, Dun Hui; Chang, I. Shou; Lai, Ling Ping; Chiang, Fu Tien; Lin, Jiunn Lee; Hsiung, Chao Agnes.

In: Annals of Medicine, Vol. 50, No. 1, 02.01.2018, p. 7-15.

Research output: Contribution to journalArticle

Chen, CYJ, Juang, JMJ, Chen, YH, Wu, IC, Hsu, CC, Wu, RC, Chen, KC, Liaw, WJ, Tsai, TL, Lin, LY, Hwang, JJ, Ho, LT, Yu, CC, Lee, JK, Wu, CK, Yeh, SFS, Yang, DH, Chang, IS, Lai, LP, Chiang, FT, Lin, JL & Hsiung, CA 2018, 'Comparisons of clinical impacts on individuals with Brugada electrocardiographic patterns defined by ISHNE criteria or EHRA/HRS/APHRS criteria: a nationwide community-based study', Annals of Medicine, vol. 50, no. 1, pp. 7-15. https://doi.org/10.1080/07853890.2017.1353222
Chen, Ching Yu Julius ; Juang, Jyh Ming Jimmy ; Chen, Ying Hsiang ; Wu, I. Chien ; Hsu, Chih Cheng ; Wu, Ray Chin ; Chen, Kwo Ching ; Liaw, Wen Jin ; Tsai, Tsung Lung ; Lin, Lian Yu ; Hwang, Juey Jen ; Ho, Li Ting ; Yu, Chih Chien ; Lee, Jen Kuang ; Wu, Cho Kai ; Yeh, Shih Fan Sherri ; Yang, Dun Hui ; Chang, I. Shou ; Lai, Ling Ping ; Chiang, Fu Tien ; Lin, Jiunn Lee ; Hsiung, Chao Agnes. / Comparisons of clinical impacts on individuals with Brugada electrocardiographic patterns defined by ISHNE criteria or EHRA/HRS/APHRS criteria : a nationwide community-based study. In: Annals of Medicine. 2018 ; Vol. 50, No. 1. pp. 7-15.
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abstract = "Introduction: Identifying Brugada electrocardiographic pattern (BrP) early is crucial to prevent sudden cardiac death. Two different diagnostic criteria proposed by International Society for Holter and Noninvasive Electrocardiography (ISHNE) and Heart Rhythm Society/European Heart Rhythm Association/Asia-Pacific Heart Rhythm Society (HRS/EHRA/APHRS) were widely used in clinical practice. The difference in prevalence and prognosis of BrP by applying the two different criteria was never studied before. Methods: This study was prospectively conducted in a nationwide large-scale stratified random sampling community-based cohort (HALST) from Han Chinese population in Taiwan from December 2008 to December 2012. We compared the prevalence and prognosis of BrP defined by the two diagnostic criteria. Results: A total of 5214 adults were enrolled (2530 men) with mean age of 69.3 years. Four had spontaneous type 1 BrP (0.077{\%}). By the HRS/EHRA/APHRS criteria, 68 individuals have type 2 BrP (1.30{\%}) and 101 have type 3 BrP (1.94{\%}) whereas by the ISHNE criteria, 46 individuals exhibited type 2 BrP (0.88{\%}). When applying the ISHNE criteria, the number of individuals with BrP decreased by 71{\%}. However, all-cause mortality and cardiovascular mortality were not different between individuals with or without BrP, irrespective of the criteria used. Conclusions: The two different criteria may impact the diagnostic yield of individuals with BrP, but do not affect the prognosis of the individuals with BrP.Key messages Comparing with the use of HRS/EHRA/APHRS criteria, the number of individuals with Brugada ECG patterns was decreased by 71{\%} when applying the ISHNE criteria. The prognosis of individuals with Brugada ECG patterns defined by 2012 ISHNE or 2013 HRS/EHRA/APHRS criteria were not different.",
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T1 - Comparisons of clinical impacts on individuals with Brugada electrocardiographic patterns defined by ISHNE criteria or EHRA/HRS/APHRS criteria

T2 - a nationwide community-based study

AU - Chen, Ching Yu Julius

AU - Juang, Jyh Ming Jimmy

AU - Chen, Ying Hsiang

AU - Wu, I. Chien

AU - Hsu, Chih Cheng

AU - Wu, Ray Chin

AU - Chen, Kwo Ching

AU - Liaw, Wen Jin

AU - Tsai, Tsung Lung

AU - Lin, Lian Yu

AU - Hwang, Juey Jen

AU - Ho, Li Ting

AU - Yu, Chih Chien

AU - Lee, Jen Kuang

AU - Wu, Cho Kai

AU - Yeh, Shih Fan Sherri

AU - Yang, Dun Hui

AU - Chang, I. Shou

AU - Lai, Ling Ping

AU - Chiang, Fu Tien

AU - Lin, Jiunn Lee

AU - Hsiung, Chao Agnes

PY - 2018/1/2

Y1 - 2018/1/2

N2 - Introduction: Identifying Brugada electrocardiographic pattern (BrP) early is crucial to prevent sudden cardiac death. Two different diagnostic criteria proposed by International Society for Holter and Noninvasive Electrocardiography (ISHNE) and Heart Rhythm Society/European Heart Rhythm Association/Asia-Pacific Heart Rhythm Society (HRS/EHRA/APHRS) were widely used in clinical practice. The difference in prevalence and prognosis of BrP by applying the two different criteria was never studied before. Methods: This study was prospectively conducted in a nationwide large-scale stratified random sampling community-based cohort (HALST) from Han Chinese population in Taiwan from December 2008 to December 2012. We compared the prevalence and prognosis of BrP defined by the two diagnostic criteria. Results: A total of 5214 adults were enrolled (2530 men) with mean age of 69.3 years. Four had spontaneous type 1 BrP (0.077%). By the HRS/EHRA/APHRS criteria, 68 individuals have type 2 BrP (1.30%) and 101 have type 3 BrP (1.94%) whereas by the ISHNE criteria, 46 individuals exhibited type 2 BrP (0.88%). When applying the ISHNE criteria, the number of individuals with BrP decreased by 71%. However, all-cause mortality and cardiovascular mortality were not different between individuals with or without BrP, irrespective of the criteria used. Conclusions: The two different criteria may impact the diagnostic yield of individuals with BrP, but do not affect the prognosis of the individuals with BrP.Key messages Comparing with the use of HRS/EHRA/APHRS criteria, the number of individuals with Brugada ECG patterns was decreased by 71% when applying the ISHNE criteria. The prognosis of individuals with Brugada ECG patterns defined by 2012 ISHNE or 2013 HRS/EHRA/APHRS criteria were not different.

AB - Introduction: Identifying Brugada electrocardiographic pattern (BrP) early is crucial to prevent sudden cardiac death. Two different diagnostic criteria proposed by International Society for Holter and Noninvasive Electrocardiography (ISHNE) and Heart Rhythm Society/European Heart Rhythm Association/Asia-Pacific Heart Rhythm Society (HRS/EHRA/APHRS) were widely used in clinical practice. The difference in prevalence and prognosis of BrP by applying the two different criteria was never studied before. Methods: This study was prospectively conducted in a nationwide large-scale stratified random sampling community-based cohort (HALST) from Han Chinese population in Taiwan from December 2008 to December 2012. We compared the prevalence and prognosis of BrP defined by the two diagnostic criteria. Results: A total of 5214 adults were enrolled (2530 men) with mean age of 69.3 years. Four had spontaneous type 1 BrP (0.077%). By the HRS/EHRA/APHRS criteria, 68 individuals have type 2 BrP (1.30%) and 101 have type 3 BrP (1.94%) whereas by the ISHNE criteria, 46 individuals exhibited type 2 BrP (0.88%). When applying the ISHNE criteria, the number of individuals with BrP decreased by 71%. However, all-cause mortality and cardiovascular mortality were not different between individuals with or without BrP, irrespective of the criteria used. Conclusions: The two different criteria may impact the diagnostic yield of individuals with BrP, but do not affect the prognosis of the individuals with BrP.Key messages Comparing with the use of HRS/EHRA/APHRS criteria, the number of individuals with Brugada ECG patterns was decreased by 71% when applying the ISHNE criteria. The prognosis of individuals with Brugada ECG patterns defined by 2012 ISHNE or 2013 HRS/EHRA/APHRS criteria were not different.

KW - Brugada electrocardiographic patterns

KW - community-based

KW - Han Chinese population

KW - long-term prognosis

KW - Prevalence

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