Comparison of thoracic radiotherapy efficacy between patients with and without EGFR-mutated lung adenocarcinoma

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Abstract

To investigate the association between tumor response to thoracic radiotherapy and epidermal growth factor receptor (EGFR) mutation status in patients with lung adenocarcinoma, we collected 48 patients treated between January 2010 and December 2013. Of the 18 patients with EGFR mutation, 15 (83.3%) had a single mutation, and three (16.7%) had double mutation. Different EGFR mutation subtypes exhibited different responses to radiotherapy. The identified double EGFR mutations were associated with reduction of residual tumor burden (RTB) after radiotherapy. In univariate analysis, EGFR mutations in exon 18, 20, and 21 and double EGFR mutation were significant factors predicting RTB. In multivariate analysis, exon 20 mutation was the only significant factor. Patients with EGFR mutation seemed to have longer mean overall survival (OS) compared to the group with wild-type EGFR (31.1 vs. 26.6 months, p=0.49). The median and mean OS in patients with double EGFR mutation vs. wild-type EGFR were 20.1 vs. 16.9 months and 28.9 vs. 26.6 months, respectively. Further studies with larger sample size are warranted to clarify the association of EGFR mutation status with the lung tumor response after radiotherapy.

Original languageEnglish
Pages (from-to)203-209
Number of pages7
JournalIn Vivo
Volume32
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

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Keywords

  • Double EGFR mutation
  • Epidermal growth factor receptor mutation
  • Lung adenocarcinoma
  • Radiotherapy
  • Multivariate Analysis
  • Prognosis
  • Humans
  • Middle Aged
  • Kaplan-Meier Estimate
  • Male
  • Treatment Outcome
  • Tumor Burden/genetics
  • Neoplasm, Residual/genetics
  • Lung Neoplasms/genetics
  • ErbB Receptors/genetics
  • Aged, 80 and over
  • Adult
  • Female
  • Adenocarcinoma/genetics
  • Aged
  • Mutation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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