Comparison of the effect of intensive versus conventional insulinotherapy in patients with cardiac surgery after cardiopulmonary bypass

Huey Ling Liou, Chun Che Shih, Kwei Chun Chung, Hsing I. Chen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Hyperglycemia occurs commonly in clinically ill patients. Insulin therapy and glycemic control have been recommended for patients with septic shock. The present study investigated the effect of intensive (INIT) versus conventional insulinotherapy (COIT) in cardiac surgery patients who received cardiopulmonary bypass (CPB). In this quasi-experimental study, a total of 50 patients undergoing coronary artery bypass grafting (CABG) were recruited into the INIT and COIT groups. Study measures included serum glucose levels, cardiac output, cytokines, C-reactive protein (CRP), duration of mechanical ventilation and length of stay in the intensive care unit (ICU), and ICU mortality rate. In the INIT group, mean blood glucose level during the first two postoperative days was significantly lower than that in the COIT group. Cardiac output was significantly greater at the second postoperative days in the INIT patients than those in the COIT group. There were no differences in cytokines, CRP levels and the outcome data between two groups. Intensive insulinotherapy reduced the blood glucose and led to improve cardiac output after CABG in comparison with conventional insulinotherapy.

Original languageEnglish
JournalChinese Journal of Physiology
Volume56
Issue number2
DOIs
Publication statusPublished - Jan 1 2013
Externally publishedYes

Fingerprint

Cardiopulmonary Bypass
Thoracic Surgery
Cardiac Output
Coronary Artery Bypass
C-Reactive Protein
Intensive Care Units
Blood Glucose
Cytokines
Septic Shock
Artificial Respiration
Hyperglycemia
Length of Stay
Insulin
Glucose
Mortality
Serum
Therapeutics

Keywords

  • Cardiac surgery patients
  • Cardiopulmonary bypass
  • Intensive insulinotherapy

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Comparison of the effect of intensive versus conventional insulinotherapy in patients with cardiac surgery after cardiopulmonary bypass. / Liou, Huey Ling; Shih, Chun Che; Chung, Kwei Chun; Chen, Hsing I.

In: Chinese Journal of Physiology, Vol. 56, No. 2, 01.01.2013.

Research output: Contribution to journalArticle

@article{8eee96109ce943b0a3f3dd9fed740410,
title = "Comparison of the effect of intensive versus conventional insulinotherapy in patients with cardiac surgery after cardiopulmonary bypass",
abstract = "Hyperglycemia occurs commonly in clinically ill patients. Insulin therapy and glycemic control have been recommended for patients with septic shock. The present study investigated the effect of intensive (INIT) versus conventional insulinotherapy (COIT) in cardiac surgery patients who received cardiopulmonary bypass (CPB). In this quasi-experimental study, a total of 50 patients undergoing coronary artery bypass grafting (CABG) were recruited into the INIT and COIT groups. Study measures included serum glucose levels, cardiac output, cytokines, C-reactive protein (CRP), duration of mechanical ventilation and length of stay in the intensive care unit (ICU), and ICU mortality rate. In the INIT group, mean blood glucose level during the first two postoperative days was significantly lower than that in the COIT group. Cardiac output was significantly greater at the second postoperative days in the INIT patients than those in the COIT group. There were no differences in cytokines, CRP levels and the outcome data between two groups. Intensive insulinotherapy reduced the blood glucose and led to improve cardiac output after CABG in comparison with conventional insulinotherapy.",
keywords = "Cardiac surgery patients, Cardiopulmonary bypass, Intensive insulinotherapy",
author = "Liou, {Huey Ling} and Shih, {Chun Che} and Chung, {Kwei Chun} and Chen, {Hsing I.}",
year = "2013",
month = "1",
day = "1",
doi = "10.4077/CJP.2013.BAA078",
language = "English",
volume = "56",
journal = "Chinese Journal of Physiology",
issn = "0304-4920",
publisher = "Chinese Physiological Society",
number = "2",

}

TY - JOUR

T1 - Comparison of the effect of intensive versus conventional insulinotherapy in patients with cardiac surgery after cardiopulmonary bypass

AU - Liou, Huey Ling

AU - Shih, Chun Che

AU - Chung, Kwei Chun

AU - Chen, Hsing I.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Hyperglycemia occurs commonly in clinically ill patients. Insulin therapy and glycemic control have been recommended for patients with septic shock. The present study investigated the effect of intensive (INIT) versus conventional insulinotherapy (COIT) in cardiac surgery patients who received cardiopulmonary bypass (CPB). In this quasi-experimental study, a total of 50 patients undergoing coronary artery bypass grafting (CABG) were recruited into the INIT and COIT groups. Study measures included serum glucose levels, cardiac output, cytokines, C-reactive protein (CRP), duration of mechanical ventilation and length of stay in the intensive care unit (ICU), and ICU mortality rate. In the INIT group, mean blood glucose level during the first two postoperative days was significantly lower than that in the COIT group. Cardiac output was significantly greater at the second postoperative days in the INIT patients than those in the COIT group. There were no differences in cytokines, CRP levels and the outcome data between two groups. Intensive insulinotherapy reduced the blood glucose and led to improve cardiac output after CABG in comparison with conventional insulinotherapy.

AB - Hyperglycemia occurs commonly in clinically ill patients. Insulin therapy and glycemic control have been recommended for patients with septic shock. The present study investigated the effect of intensive (INIT) versus conventional insulinotherapy (COIT) in cardiac surgery patients who received cardiopulmonary bypass (CPB). In this quasi-experimental study, a total of 50 patients undergoing coronary artery bypass grafting (CABG) were recruited into the INIT and COIT groups. Study measures included serum glucose levels, cardiac output, cytokines, C-reactive protein (CRP), duration of mechanical ventilation and length of stay in the intensive care unit (ICU), and ICU mortality rate. In the INIT group, mean blood glucose level during the first two postoperative days was significantly lower than that in the COIT group. Cardiac output was significantly greater at the second postoperative days in the INIT patients than those in the COIT group. There were no differences in cytokines, CRP levels and the outcome data between two groups. Intensive insulinotherapy reduced the blood glucose and led to improve cardiac output after CABG in comparison with conventional insulinotherapy.

KW - Cardiac surgery patients

KW - Cardiopulmonary bypass

KW - Intensive insulinotherapy

UR - http://www.scopus.com/inward/record.url?scp=84875936634&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875936634&partnerID=8YFLogxK

U2 - 10.4077/CJP.2013.BAA078

DO - 10.4077/CJP.2013.BAA078

M3 - Article

C2 - 23589926

AN - SCOPUS:84875936634

VL - 56

JO - Chinese Journal of Physiology

JF - Chinese Journal of Physiology

SN - 0304-4920

IS - 2

ER -