Comparison of prognosis by viral etiology in patients with hepatocellular carcinoma after radiofrequency ablation

Ping Hsien Chen, Wei Yu Kao, Yi You Chiou, Hung Hsu Hung, Chien Wei Su, Yi Hong Chou, Teh Ia Huo, Yi Hsiang Huang, Wen Chieh Wu, Yee Chao, Han Chieh Lin, Jaw Ching Wu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background. Radiofrequency ablation (RFA) has been performed as a first line curative treatment modality for patients with hepatocellular carcinoma (HCC) within the Milan criteria currently. However, prognosis of hepatitis B- and hepatitis C-related HCC after RFA remains debatable. This study aimed to assess the impact of viral etiology on the prognosis of HCC patients undergoing RFA. Material and methods. One hundred and ninety-two patients with positive serum HBV surface antigen (HBsAg) and negative serum antibody against HCV (anti-HCV) were enrolled as the B-HCC group and 165 patients with negative serum HBsAg and positive anti-HCV as the C-HCC group. Post-RFA prognoses were compared between the two groups using multivariate and propensity score matching analyses. Results. The B-HCC group had higher male-to-female ratio and better liver functional reserve than the C-HCC group. After a median follow-up of 23.0 ± 22.7 months, 55 patients died and 189 patients had tumor recurrence after RFA. The cumulative fiveyear survival rate was 75.9% and 69.5% in the B-HCC and C-HCC groups, respectively (p = 0.312), while the five-year recurrence-free survival rate was 19.0% and 26.6%, respectively (p = 0.490). After propensity-score matching, the B-HCC group still had comparable overall survival rate (p = 0.679) and recurrence-free survival rate (p = 0.689) to the C-HCC group. For 132 patients with Barcelona-Clinic Liver Cancer stage 0, the fiveyear overall survival and recurrence-free survival rates were also comparable between the two groups (p = 0.559 and p = 0.872, respectively). Conclusion. Viral etiology is not essential for determining outcome in HCC patients undergoing RFA.

Original languageEnglish
Pages (from-to)263-273
Number of pages11
JournalAnnals of Hepatology
Volume12
Issue number2
Publication statusPublished - Mar 1 2013
Externally publishedYes

Fingerprint

Hepatocellular Carcinoma
Survival Rate
Recurrence
Propensity Score
Hepatitis C Antibodies
Surface Antigens
Serum
Liver Neoplasms
Hepatitis C
Hepatitis B
Survival
Liver

Keywords

  • Hepatitis B virus
  • Hepatitis C virus
  • Hepatocellular carcinoma
  • Prognosis
  • Radiofrequency ablation

ASJC Scopus subject areas

  • Hepatology

Cite this

Chen, P. H., Kao, W. Y., Chiou, Y. Y., Hung, H. H., Su, C. W., Chou, Y. H., ... Wu, J. C. (2013). Comparison of prognosis by viral etiology in patients with hepatocellular carcinoma after radiofrequency ablation. Annals of Hepatology, 12(2), 263-273.

Comparison of prognosis by viral etiology in patients with hepatocellular carcinoma after radiofrequency ablation. / Chen, Ping Hsien; Kao, Wei Yu; Chiou, Yi You; Hung, Hung Hsu; Su, Chien Wei; Chou, Yi Hong; Huo, Teh Ia; Huang, Yi Hsiang; Wu, Wen Chieh; Chao, Yee; Lin, Han Chieh; Wu, Jaw Ching.

In: Annals of Hepatology, Vol. 12, No. 2, 01.03.2013, p. 263-273.

Research output: Contribution to journalArticle

Chen, PH, Kao, WY, Chiou, YY, Hung, HH, Su, CW, Chou, YH, Huo, TI, Huang, YH, Wu, WC, Chao, Y, Lin, HC & Wu, JC 2013, 'Comparison of prognosis by viral etiology in patients with hepatocellular carcinoma after radiofrequency ablation', Annals of Hepatology, vol. 12, no. 2, pp. 263-273.
Chen, Ping Hsien ; Kao, Wei Yu ; Chiou, Yi You ; Hung, Hung Hsu ; Su, Chien Wei ; Chou, Yi Hong ; Huo, Teh Ia ; Huang, Yi Hsiang ; Wu, Wen Chieh ; Chao, Yee ; Lin, Han Chieh ; Wu, Jaw Ching. / Comparison of prognosis by viral etiology in patients with hepatocellular carcinoma after radiofrequency ablation. In: Annals of Hepatology. 2013 ; Vol. 12, No. 2. pp. 263-273.
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abstract = "Background. Radiofrequency ablation (RFA) has been performed as a first line curative treatment modality for patients with hepatocellular carcinoma (HCC) within the Milan criteria currently. However, prognosis of hepatitis B- and hepatitis C-related HCC after RFA remains debatable. This study aimed to assess the impact of viral etiology on the prognosis of HCC patients undergoing RFA. Material and methods. One hundred and ninety-two patients with positive serum HBV surface antigen (HBsAg) and negative serum antibody against HCV (anti-HCV) were enrolled as the B-HCC group and 165 patients with negative serum HBsAg and positive anti-HCV as the C-HCC group. Post-RFA prognoses were compared between the two groups using multivariate and propensity score matching analyses. Results. The B-HCC group had higher male-to-female ratio and better liver functional reserve than the C-HCC group. After a median follow-up of 23.0 ± 22.7 months, 55 patients died and 189 patients had tumor recurrence after RFA. The cumulative fiveyear survival rate was 75.9{\%} and 69.5{\%} in the B-HCC and C-HCC groups, respectively (p = 0.312), while the five-year recurrence-free survival rate was 19.0{\%} and 26.6{\%}, respectively (p = 0.490). After propensity-score matching, the B-HCC group still had comparable overall survival rate (p = 0.679) and recurrence-free survival rate (p = 0.689) to the C-HCC group. For 132 patients with Barcelona-Clinic Liver Cancer stage 0, the fiveyear overall survival and recurrence-free survival rates were also comparable between the two groups (p = 0.559 and p = 0.872, respectively). Conclusion. Viral etiology is not essential for determining outcome in HCC patients undergoing RFA.",
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AU - Chen, Ping Hsien

AU - Kao, Wei Yu

AU - Chiou, Yi You

AU - Hung, Hung Hsu

AU - Su, Chien Wei

AU - Chou, Yi Hong

AU - Huo, Teh Ia

AU - Huang, Yi Hsiang

AU - Wu, Wen Chieh

AU - Chao, Yee

AU - Lin, Han Chieh

AU - Wu, Jaw Ching

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N2 - Background. Radiofrequency ablation (RFA) has been performed as a first line curative treatment modality for patients with hepatocellular carcinoma (HCC) within the Milan criteria currently. However, prognosis of hepatitis B- and hepatitis C-related HCC after RFA remains debatable. This study aimed to assess the impact of viral etiology on the prognosis of HCC patients undergoing RFA. Material and methods. One hundred and ninety-two patients with positive serum HBV surface antigen (HBsAg) and negative serum antibody against HCV (anti-HCV) were enrolled as the B-HCC group and 165 patients with negative serum HBsAg and positive anti-HCV as the C-HCC group. Post-RFA prognoses were compared between the two groups using multivariate and propensity score matching analyses. Results. The B-HCC group had higher male-to-female ratio and better liver functional reserve than the C-HCC group. After a median follow-up of 23.0 ± 22.7 months, 55 patients died and 189 patients had tumor recurrence after RFA. The cumulative fiveyear survival rate was 75.9% and 69.5% in the B-HCC and C-HCC groups, respectively (p = 0.312), while the five-year recurrence-free survival rate was 19.0% and 26.6%, respectively (p = 0.490). After propensity-score matching, the B-HCC group still had comparable overall survival rate (p = 0.679) and recurrence-free survival rate (p = 0.689) to the C-HCC group. For 132 patients with Barcelona-Clinic Liver Cancer stage 0, the fiveyear overall survival and recurrence-free survival rates were also comparable between the two groups (p = 0.559 and p = 0.872, respectively). Conclusion. Viral etiology is not essential for determining outcome in HCC patients undergoing RFA.

AB - Background. Radiofrequency ablation (RFA) has been performed as a first line curative treatment modality for patients with hepatocellular carcinoma (HCC) within the Milan criteria currently. However, prognosis of hepatitis B- and hepatitis C-related HCC after RFA remains debatable. This study aimed to assess the impact of viral etiology on the prognosis of HCC patients undergoing RFA. Material and methods. One hundred and ninety-two patients with positive serum HBV surface antigen (HBsAg) and negative serum antibody against HCV (anti-HCV) were enrolled as the B-HCC group and 165 patients with negative serum HBsAg and positive anti-HCV as the C-HCC group. Post-RFA prognoses were compared between the two groups using multivariate and propensity score matching analyses. Results. The B-HCC group had higher male-to-female ratio and better liver functional reserve than the C-HCC group. After a median follow-up of 23.0 ± 22.7 months, 55 patients died and 189 patients had tumor recurrence after RFA. The cumulative fiveyear survival rate was 75.9% and 69.5% in the B-HCC and C-HCC groups, respectively (p = 0.312), while the five-year recurrence-free survival rate was 19.0% and 26.6%, respectively (p = 0.490). After propensity-score matching, the B-HCC group still had comparable overall survival rate (p = 0.679) and recurrence-free survival rate (p = 0.689) to the C-HCC group. For 132 patients with Barcelona-Clinic Liver Cancer stage 0, the fiveyear overall survival and recurrence-free survival rates were also comparable between the two groups (p = 0.559 and p = 0.872, respectively). Conclusion. Viral etiology is not essential for determining outcome in HCC patients undergoing RFA.

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KW - Hepatitis C virus

KW - Hepatocellular carcinoma

KW - Prognosis

KW - Radiofrequency ablation

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