Comparison of Oxidative DNA Damage Between Alcohol-Dependent Patients With and Without Delirium Tremens

Ming Chyi Huang, Chiao Chicy Chen, Chun Hung Pan, Chun Hsin Chen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Chronic and excessive alcohol consumption increases oxidative stress. We previously found that levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, are elevated in alcohol-dependent patients without delirium tremens (DTs). The aim of this study was to compare serum 8-OHdG levels between alcohol-dependent patients with and without DTs. Methods: We recruited 16 alcohol-dependent patients with DTs (DTs group) and 58 patients without DTs (non-DTs group). Alcohol withdrawal severity was evaluated using the Chinese version of the revised Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar-C) every 8 hours. Serum levels of 8-OHdG and other biological indices were assayed at baseline and after 1 week of detoxification. Results: The mean 8-OHdG level in the DTs group was significantly higher than that in the non-DTs group (0.50 vs. 0.34 ng/ml, p 

Original languageEnglish
Pages (from-to)2523-2528
Number of pages6
JournalAlcoholism: Clinical and Experimental Research
Volume38
Issue number10
DOIs
Publication statusPublished - Oct 1 2014

Fingerprint

Alcohol Withdrawal Delirium
DNA Damage
Alcohols
DNA
Detoxification
Oxidative stress
Serum
Alcohol Drinking
Oxidative Stress

Keywords

  • 8-Hydroxy-2′-Deoxyguanosine
  • Alcohol Dependence
  • Alcohol Withdrawal
  • Delirium Tremens
  • Oxidative Stress

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Toxicology
  • Medicine(all)

Cite this

Comparison of Oxidative DNA Damage Between Alcohol-Dependent Patients With and Without Delirium Tremens. / Huang, Ming Chyi; Chen, Chiao Chicy; Pan, Chun Hung; Chen, Chun Hsin.

In: Alcoholism: Clinical and Experimental Research, Vol. 38, No. 10, 01.10.2014, p. 2523-2528.

Research output: Contribution to journalArticle

@article{e140380cc9c84ec4b73e914dda22feff,
title = "Comparison of Oxidative DNA Damage Between Alcohol-Dependent Patients With and Without Delirium Tremens",
abstract = "Background: Chronic and excessive alcohol consumption increases oxidative stress. We previously found that levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, are elevated in alcohol-dependent patients without delirium tremens (DTs). The aim of this study was to compare serum 8-OHdG levels between alcohol-dependent patients with and without DTs. Methods: We recruited 16 alcohol-dependent patients with DTs (DTs group) and 58 patients without DTs (non-DTs group). Alcohol withdrawal severity was evaluated using the Chinese version of the revised Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar-C) every 8 hours. Serum levels of 8-OHdG and other biological indices were assayed at baseline and after 1 week of detoxification. Results: The mean 8-OHdG level in the DTs group was significantly higher than that in the non-DTs group (0.50 vs. 0.34 ng/ml, p ",
keywords = "8-Hydroxy-2′-Deoxyguanosine, Alcohol Dependence, Alcohol Withdrawal, Delirium Tremens, Oxidative Stress",
author = "Huang, {Ming Chyi} and Chen, {Chiao Chicy} and Pan, {Chun Hung} and Chen, {Chun Hsin}",
year = "2014",
month = "10",
day = "1",
doi = "10.1111/acer.12539",
language = "English",
volume = "38",
pages = "2523--2528",
journal = "Alcoholism: Clinical and Experimental Research",
issn = "0145-6008",
publisher = "Wiley-Blackwell",
number = "10",

}

TY - JOUR

T1 - Comparison of Oxidative DNA Damage Between Alcohol-Dependent Patients With and Without Delirium Tremens

AU - Huang, Ming Chyi

AU - Chen, Chiao Chicy

AU - Pan, Chun Hung

AU - Chen, Chun Hsin

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Background: Chronic and excessive alcohol consumption increases oxidative stress. We previously found that levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, are elevated in alcohol-dependent patients without delirium tremens (DTs). The aim of this study was to compare serum 8-OHdG levels between alcohol-dependent patients with and without DTs. Methods: We recruited 16 alcohol-dependent patients with DTs (DTs group) and 58 patients without DTs (non-DTs group). Alcohol withdrawal severity was evaluated using the Chinese version of the revised Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar-C) every 8 hours. Serum levels of 8-OHdG and other biological indices were assayed at baseline and after 1 week of detoxification. Results: The mean 8-OHdG level in the DTs group was significantly higher than that in the non-DTs group (0.50 vs. 0.34 ng/ml, p 

AB - Background: Chronic and excessive alcohol consumption increases oxidative stress. We previously found that levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, are elevated in alcohol-dependent patients without delirium tremens (DTs). The aim of this study was to compare serum 8-OHdG levels between alcohol-dependent patients with and without DTs. Methods: We recruited 16 alcohol-dependent patients with DTs (DTs group) and 58 patients without DTs (non-DTs group). Alcohol withdrawal severity was evaluated using the Chinese version of the revised Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar-C) every 8 hours. Serum levels of 8-OHdG and other biological indices were assayed at baseline and after 1 week of detoxification. Results: The mean 8-OHdG level in the DTs group was significantly higher than that in the non-DTs group (0.50 vs. 0.34 ng/ml, p 

KW - 8-Hydroxy-2′-Deoxyguanosine

KW - Alcohol Dependence

KW - Alcohol Withdrawal

KW - Delirium Tremens

KW - Oxidative Stress

UR - http://www.scopus.com/inward/record.url?scp=84911390464&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84911390464&partnerID=8YFLogxK

U2 - 10.1111/acer.12539

DO - 10.1111/acer.12539

M3 - Article

C2 - 25336159

AN - SCOPUS:84911390464

VL - 38

SP - 2523

EP - 2528

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

SN - 0145-6008

IS - 10

ER -