Comparison of Oxidative DNA Damage Between Alcohol-Dependent Patients With and Without Delirium Tremens

Ming Chyi Huang; Chiao Chicy Chen; Chun Hung Pan; Chun Hsin Chen

doi:10.1111/acer.12539

Comparison of Oxidative DNA Damage Between Alcohol-Dependent Patients With and Without Delirium Tremens

Ming Chyi Huang, Chiao Chicy Chen, Chun Hung Pan, Chun Hsin Chen

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Background: Chronic and excessive alcohol consumption increases oxidative stress. We previously found that levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, are elevated in alcohol-dependent patients without delirium tremens (DTs). The aim of this study was to compare serum 8-OHdG levels between alcohol-dependent patients with and without DTs. Methods: We recruited 16 alcohol-dependent patients with DTs (DTs group) and 58 patients without DTs (non-DTs group). Alcohol withdrawal severity was evaluated using the Chinese version of the revised Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar-C) every 8 hours. Serum levels of 8-OHdG and other biological indices were assayed at baseline and after 1 week of detoxification. Results: The mean 8-OHdG level in the DTs group was significantly higher than that in the non-DTs group (0.50 vs. 0.34 ng/ml, p

Original language	English
Pages (from-to)	2523-2528
Number of pages	6
Journal	Alcoholism: Clinical and Experimental Research
Volume	38
Issue number	10
DOIs	https://doi.org/10.1111/acer.12539
Publication status	Published - Oct 1 2014

Keywords

8-Hydroxy-2′-Deoxyguanosine
Alcohol Dependence
Alcohol Withdrawal
Delirium Tremens
Oxidative Stress

ASJC Scopus subject areas

Medicine (miscellaneous)
Psychiatry and Mental health
Toxicology
Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/acer.12539

Cite this

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title = "Comparison of Oxidative DNA Damage Between Alcohol-Dependent Patients With and Without Delirium Tremens",

abstract = "Background: Chronic and excessive alcohol consumption increases oxidative stress. We previously found that levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, are elevated in alcohol-dependent patients without delirium tremens (DTs). The aim of this study was to compare serum 8-OHdG levels between alcohol-dependent patients with and without DTs. Methods: We recruited 16 alcohol-dependent patients with DTs (DTs group) and 58 patients without DTs (non-DTs group). Alcohol withdrawal severity was evaluated using the Chinese version of the revised Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar-C) every 8 hours. Serum levels of 8-OHdG and other biological indices were assayed at baseline and after 1 week of detoxification. Results: The mean 8-OHdG level in the DTs group was significantly higher than that in the non-DTs group (0.50 vs. 0.34 ng/ml, p ",

keywords = "8-Hydroxy-2′-Deoxyguanosine, Alcohol Dependence, Alcohol Withdrawal, Delirium Tremens, Oxidative Stress",

author = "Huang, {Ming Chyi} and Chen, {Chiao Chicy} and Pan, {Chun Hung} and Chen, {Chun Hsin}",

year = "2014",

month = oct,

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doi = "10.1111/acer.12539",

language = "English",

volume = "38",

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journal = "Alcoholism: Clinical and Experimental Research",

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T1 - Comparison of Oxidative DNA Damage Between Alcohol-Dependent Patients With and Without Delirium Tremens

AU - Huang, Ming Chyi

AU - Chen, Chiao Chicy

AU - Pan, Chun Hung

AU - Chen, Chun Hsin

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Background: Chronic and excessive alcohol consumption increases oxidative stress. We previously found that levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, are elevated in alcohol-dependent patients without delirium tremens (DTs). The aim of this study was to compare serum 8-OHdG levels between alcohol-dependent patients with and without DTs. Methods: We recruited 16 alcohol-dependent patients with DTs (DTs group) and 58 patients without DTs (non-DTs group). Alcohol withdrawal severity was evaluated using the Chinese version of the revised Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar-C) every 8 hours. Serum levels of 8-OHdG and other biological indices were assayed at baseline and after 1 week of detoxification. Results: The mean 8-OHdG level in the DTs group was significantly higher than that in the non-DTs group (0.50 vs. 0.34 ng/ml, p

AB - Background: Chronic and excessive alcohol consumption increases oxidative stress. We previously found that levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, are elevated in alcohol-dependent patients without delirium tremens (DTs). The aim of this study was to compare serum 8-OHdG levels between alcohol-dependent patients with and without DTs. Methods: We recruited 16 alcohol-dependent patients with DTs (DTs group) and 58 patients without DTs (non-DTs group). Alcohol withdrawal severity was evaluated using the Chinese version of the revised Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar-C) every 8 hours. Serum levels of 8-OHdG and other biological indices were assayed at baseline and after 1 week of detoxification. Results: The mean 8-OHdG level in the DTs group was significantly higher than that in the non-DTs group (0.50 vs. 0.34 ng/ml, p

KW - 8-Hydroxy-2′-Deoxyguanosine

KW - Alcohol Dependence

KW - Alcohol Withdrawal

KW - Delirium Tremens

KW - Oxidative Stress

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Comparison of Oxidative DNA Damage Between Alcohol-Dependent Patients With and Without Delirium Tremens

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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