Comparison of Oxidative DNA Damage Between Alcohol-Dependent Patients With and Without Delirium Tremens

Ming Chyi Huang, Chiao Chicy Chen, Chun Hung Pan, Chun Hsin Chen

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6 Citations (Scopus)

Abstract

Background: Chronic and excessive alcohol consumption increases oxidative stress. We previously found that levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, are elevated in alcohol-dependent patients without delirium tremens (DTs). The aim of this study was to compare serum 8-OHdG levels between alcohol-dependent patients with and without DTs. Methods: We recruited 16 alcohol-dependent patients with DTs (DTs group) and 58 patients without DTs (non-DTs group). Alcohol withdrawal severity was evaluated using the Chinese version of the revised Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar-C) every 8 hours. Serum levels of 8-OHdG and other biological indices were assayed at baseline and after 1 week of detoxification. Results: The mean 8-OHdG level in the DTs group was significantly higher than that in the non-DTs group (0.50 vs. 0.34 ng/ml, p 

Original languageEnglish
Pages (from-to)2523-2528
Number of pages6
JournalAlcoholism: Clinical and Experimental Research
Volume38
Issue number10
DOIs
Publication statusPublished - Oct 1 2014

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Keywords

  • 8-Hydroxy-2′-Deoxyguanosine
  • Alcohol Dependence
  • Alcohol Withdrawal
  • Delirium Tremens
  • Oxidative Stress

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Toxicology
  • Medicine(all)

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