比較磁振攝影與電腦斷層對鼻咽癌顱內蔓延之偵檢及分析對治療成果之影響

Translated title of the contribution: Comparison of MRI and CT to Detect Intracranial Extension and Analyzing the Impact on Treatment Outcome in Nasopharyngeal Carcinoma

許維中, 丁禮莉, 鍾娜娜, 洪瑞隆, 柯政郁, 王博民, 詹淑卿

Research output: Contribution to journalArticle

Abstract

Purpose: To compare magnetic resonance imaging (MRI) and computed tomography (CT) in detecting intracranial extension of the patients with nasopharyngeal carcinoma (NPC) and to analyze the impact on treatment outcome.Materials and Methods: From December 1997 to December 2004, 587 patients with histologically confirmed NPC (Iess than or equal to stage IVA according to American Joint Committee on Cancer, sixth edition) and received therapeutic radiation dose who underwent CT and MRI for evaluation of primary tumor extension. AII o f the images were reviewed and assessed by two physicians independently. Cases with variable interpretation or disagreement between the observers, these images were reevaluated side by side and any discrepancy was resolved by consensus. The kappa test for inter-observer concordance was 0.841 for CT and 0.931 for MRI.Results: The detection rate of intracranial invasion by MRI was 62.7% and that by CT was 15.5% (p<0.001). The group with no intracranial invasion detected by MRI or CT (group 1) had significantly higher overall survival rate than intracranial invasion detected by MRI but not by CT (group 2, p<0.001) or intracranial invasion detected by both MRI and CT (group 3, p<0.001). For group 2 patients, chemotherapy plus radiotherapy had higher overall survival rate than radiotherapy alone (p<0.001). Group 2 and 3 had the odd ratio of 3.2 and 4.0 comparing to group 1 by Cox regression. According to different treatment modalities, patients treated by radiotherapy alone had odd ratio of 2.6 comparing to chemotherapy plus radiotherapy.Conclusion: MRI owned a higher intracranial invasion detection rate than CT. Patients with intracranial involvement should receive both chemotherapy and radiotherapy in order to improve overall survival, even those with only subtle intracranial invasion.
Original languageTraditional Chinese
Pages (from-to)181-188
Number of pages8
Journal放射治療與腫瘤學
Volume19
Issue number3
DOIs
Publication statusPublished - 2012

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Tomography
Magnetic Resonance Imaging
Radiotherapy
Drug Therapy
Survival Rate
Odds Ratio
Nasopharyngeal carcinoma
Neoplasms
Radiation
Physicians
Survival
Therapeutics

Keywords

  • Intracranial invasion
  • Nasopharyngeal carcinoma
  • Survival

Cite this

比較磁振攝影與電腦斷層對鼻咽癌顱內蔓延之偵檢及分析對治療成果之影響. / 許維中; 丁禮莉; 鍾娜娜; 洪瑞隆; 柯政郁; 王博民; 詹淑卿.

In: 放射治療與腫瘤學, Vol. 19, No. 3, 2012, p. 181-188.

Research output: Contribution to journalArticle

許維中 ; 丁禮莉 ; 鍾娜娜 ; 洪瑞隆 ; 柯政郁 ; 王博民 ; 詹淑卿. / 比較磁振攝影與電腦斷層對鼻咽癌顱內蔓延之偵檢及分析對治療成果之影響. In: 放射治療與腫瘤學. 2012 ; Vol. 19, No. 3. pp. 181-188.
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title = "比較磁振攝影與電腦斷層對鼻咽癌顱內蔓延之偵檢及分析對治療成果之影響",
abstract = "Purpose: To compare magnetic resonance imaging (MRI) and computed tomography (CT) in detecting intracranial extension of the patients with nasopharyngeal carcinoma (NPC) and to analyze the impact on treatment outcome.Materials and Methods: From December 1997 to December 2004, 587 patients with histologically confirmed NPC (Iess than or equal to stage IVA according to American Joint Committee on Cancer, sixth edition) and received therapeutic radiation dose who underwent CT and MRI for evaluation of primary tumor extension. AII o f the images were reviewed and assessed by two physicians independently. Cases with variable interpretation or disagreement between the observers, these images were reevaluated side by side and any discrepancy was resolved by consensus. The kappa test for inter-observer concordance was 0.841 for CT and 0.931 for MRI.Results: The detection rate of intracranial invasion by MRI was 62.7{\%} and that by CT was 15.5{\%} (p<0.001). The group with no intracranial invasion detected by MRI or CT (group 1) had significantly higher overall survival rate than intracranial invasion detected by MRI but not by CT (group 2, p<0.001) or intracranial invasion detected by both MRI and CT (group 3, p<0.001). For group 2 patients, chemotherapy plus radiotherapy had higher overall survival rate than radiotherapy alone (p<0.001). Group 2 and 3 had the odd ratio of 3.2 and 4.0 comparing to group 1 by Cox regression. According to different treatment modalities, patients treated by radiotherapy alone had odd ratio of 2.6 comparing to chemotherapy plus radiotherapy.Conclusion: MRI owned a higher intracranial invasion detection rate than CT. Patients with intracranial involvement should receive both chemotherapy and radiotherapy in order to improve overall survival, even those with only subtle intracranial invasion.",
keywords = "顱內蔓延, 鼻咽癌, 存活率, Intracranial invasion, Nasopharyngeal carcinoma, Survival",
author = "許維中 and 丁禮莉 and 鍾娜娜 and 洪瑞隆 and 柯政郁 and 王博民 and 詹淑卿",
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TY - JOUR

T1 - 比較磁振攝影與電腦斷層對鼻咽癌顱內蔓延之偵檢及分析對治療成果之影響

AU - 許維中, null

AU - 丁禮莉, null

AU - 鍾娜娜, null

AU - 洪瑞隆, null

AU - 柯政郁, null

AU - 王博民, null

AU - 詹淑卿, null

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N2 - Purpose: To compare magnetic resonance imaging (MRI) and computed tomography (CT) in detecting intracranial extension of the patients with nasopharyngeal carcinoma (NPC) and to analyze the impact on treatment outcome.Materials and Methods: From December 1997 to December 2004, 587 patients with histologically confirmed NPC (Iess than or equal to stage IVA according to American Joint Committee on Cancer, sixth edition) and received therapeutic radiation dose who underwent CT and MRI for evaluation of primary tumor extension. AII o f the images were reviewed and assessed by two physicians independently. Cases with variable interpretation or disagreement between the observers, these images were reevaluated side by side and any discrepancy was resolved by consensus. The kappa test for inter-observer concordance was 0.841 for CT and 0.931 for MRI.Results: The detection rate of intracranial invasion by MRI was 62.7% and that by CT was 15.5% (p<0.001). The group with no intracranial invasion detected by MRI or CT (group 1) had significantly higher overall survival rate than intracranial invasion detected by MRI but not by CT (group 2, p<0.001) or intracranial invasion detected by both MRI and CT (group 3, p<0.001). For group 2 patients, chemotherapy plus radiotherapy had higher overall survival rate than radiotherapy alone (p<0.001). Group 2 and 3 had the odd ratio of 3.2 and 4.0 comparing to group 1 by Cox regression. According to different treatment modalities, patients treated by radiotherapy alone had odd ratio of 2.6 comparing to chemotherapy plus radiotherapy.Conclusion: MRI owned a higher intracranial invasion detection rate than CT. Patients with intracranial involvement should receive both chemotherapy and radiotherapy in order to improve overall survival, even those with only subtle intracranial invasion.

AB - Purpose: To compare magnetic resonance imaging (MRI) and computed tomography (CT) in detecting intracranial extension of the patients with nasopharyngeal carcinoma (NPC) and to analyze the impact on treatment outcome.Materials and Methods: From December 1997 to December 2004, 587 patients with histologically confirmed NPC (Iess than or equal to stage IVA according to American Joint Committee on Cancer, sixth edition) and received therapeutic radiation dose who underwent CT and MRI for evaluation of primary tumor extension. AII o f the images were reviewed and assessed by two physicians independently. Cases with variable interpretation or disagreement between the observers, these images were reevaluated side by side and any discrepancy was resolved by consensus. The kappa test for inter-observer concordance was 0.841 for CT and 0.931 for MRI.Results: The detection rate of intracranial invasion by MRI was 62.7% and that by CT was 15.5% (p<0.001). The group with no intracranial invasion detected by MRI or CT (group 1) had significantly higher overall survival rate than intracranial invasion detected by MRI but not by CT (group 2, p<0.001) or intracranial invasion detected by both MRI and CT (group 3, p<0.001). For group 2 patients, chemotherapy plus radiotherapy had higher overall survival rate than radiotherapy alone (p<0.001). Group 2 and 3 had the odd ratio of 3.2 and 4.0 comparing to group 1 by Cox regression. According to different treatment modalities, patients treated by radiotherapy alone had odd ratio of 2.6 comparing to chemotherapy plus radiotherapy.Conclusion: MRI owned a higher intracranial invasion detection rate than CT. Patients with intracranial involvement should receive both chemotherapy and radiotherapy in order to improve overall survival, even those with only subtle intracranial invasion.

KW - 顱內蔓延

KW - 鼻咽癌

KW - 存活率

KW - Intracranial invasion

KW - Nasopharyngeal carcinoma

KW - Survival

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U2 - 10.6316/TRO/201219(3)181

DO - 10.6316/TRO/201219(3)181

M3 - 文章

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EP - 188

JO - 放射治療與腫瘤學

JF - 放射治療與腫瘤學

SN - 1023-988x

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ER -