Comparison of left atrial volume parameters in detecting left ventricular diastolic dysfunction versus tissue Doppler recordings

Shih Hung Hsiao, Ko Long Lin, Kuan Rau Chiou

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Because of diastolic coupling between the left atrium and left ventricle, we hypothesized that left atrial (LA) function mirrors the diastolic function of left ventricle. The aims of this study were to assess whether LA volume parameters can be good indexes of left ventricular diastolic dysfunction. Six hundred fifty-nine patients underwent cardiac catheterization and measurements of left ventricular filling pressure (LVFP). Echocardiographic examinations including tissue Doppler and LA volumes were also assessed. Ratio of early diastolic mitral inflow velocity to early diastolic mitral annular velocity and LVFP tended to increase after progression of diastolic dysfunction. The inverse phenomenon existed in LA ejection and LA distensibility. LA distensibility was superior to LA ejection fraction and early diastolic mitral inflow velocity/early diastolic mitral annular velocity for identifying LVFP >15 mm Hg (areas under receiver operating characteristic curve 0.868, 0.834, and 0.759, respectively) and for differentiating pseudonormal from normal diastolic filling (areas under receiver operating characteristic curve 0.962, 0.907, and 0.741, respectively). Multivariate logistic regression showed that LA ejection fraction and LA distensibility were associated significantly with the presence of pseudonormal/restrictive ventricular filling. In conclusion, LA volume parameters can identify LVFP >15 mm Hg and differentiate among patterns of ventricular diastolic dysfunction. For assessing diastolic function LA parameters offer better performance than even tissue Doppler.

Original languageEnglish
Pages (from-to)748-755
Number of pages8
JournalAmerican Journal of Cardiology
Volume109
Issue number5
DOIs
Publication statusPublished - Mar 1 2012
Externally publishedYes

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Left Ventricular Dysfunction
Ventricular Pressure
Left Atrial Function
ROC Curve
Heart Ventricles
Ventricular Dysfunction
Cardiac Catheterization
Heart Atria
Logistic Models

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Comparison of left atrial volume parameters in detecting left ventricular diastolic dysfunction versus tissue Doppler recordings. / Hsiao, Shih Hung; Lin, Ko Long; Chiou, Kuan Rau.

In: American Journal of Cardiology, Vol. 109, No. 5, 01.03.2012, p. 748-755.

Research output: Contribution to journalArticle

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